Abstract
The influence of drugs on body weight and food drive is complex and intriguing. Multiple brain areas are involved in the regulation of eating behaviors, and psychotropic drugs can play a role in this regard. The dopaminergic activity of many medications has to do also with the complex mechanisms of reward in the brain. While prescribing a psychotropic drug, its effects on body weight and appetite should be carefully considered. Weight gain could determine reduced compliance to therapy, especially for those patients who present a comorbid eating disorder or have a history of overweight or obesity. Similarly, medications that cause weight loss could be used by patients as a pathological way to control their weight. This chapter will focus on those psychotropic agents that increase and decrease appetite and weight.
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References
Kessler RC, Berglund PA, Chiu WT, et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013;73(9):904–14.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. 2013. https://doi.org/10.1176/appi.books.9780890425596.744053.
Trinko R, Sears RM, Guarnieri DJ, DiLeone RJ. Neural mechanisms underlying obesity and drug addiction. Physiol Behav. 2007;91(5):499–505. Epub 2007 Jan 16.
Bak M, Fransen A, Janssen J, van Os J, Drukker M. Almost all antipsychotics result in weight gain: a meta-analysis. PLoS One. 2014;9(4):e94112. https://doi.org/10.1371/journal.pone.0094112.
Tarricone I, Ferrari Gozzi B, Serretti A, Grieco D, Berardi D. Weight gain in antipsychotic-naive patients: a review and meta-analysis. Psychol Med. 2010;40:187–200.
Nielsen MØ, Rostrup E, Wulff S, Glenthøj B, Ebdrup BH. Striatal reward activity and antipsychotic-associated weight change in patients with schizophrenia undergoing initial treatment. JAMA Psychiat. 2016;73:121–8.
Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009;373:31–41.
Coccurello R, Moles A. Potential mechanisms of atypical antipsychotic-induced metabolic derangement: clues for understanding obesity and novel drug design. Pharmacol Ther. 2010;127:210–51. https://doi.org/10.1016/j.pharmthera.2010.04.008.
Albaugh VL, Singareddy R, Mauger D, Lynch CJ. A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers. PLoS One. 2011;6:e22662.
Takeuchi Y, Kajiyama K, Ishiguro C, Uyama Y. Atypical antipsychotics and the risk of hyperlipidemia: a sequence symmetry analysis. Drug Saf. 2015;38:641–50.
Potvin S, Zhornitsky S, Stip E. Antipsychotic-induced changes in blood levels of leptin in schizophrenia: a meta-analysis. Can J Psychiatry. 2015;60:S26.
Zhang Q, Deng C, Huang XF. The role of ghrelin signalling in second-generation antipsychotic-induced weight gain. Psychoneuroendocrinology. 2013;38(11):2423–38. https://doi.org/10.1016/j.psyneuen.2013.07.010. Epub 2013 Aug 14. Review.
Kanji S, Fonseka TM, Marshe VS, Sriretnakumar V, Hahn MK, Müller DJ. The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain. Eur Arch Psychiatry Clin Neurosci. 2018;268:3–15.
Bond DJ, Kauer-Sant’Anna M, Lam RW, Yatham LN. Weight gain, obesity, and metabolic indices following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM). J Affect Disord. 2010;124(1–2):108–17. https://doi.org/10.1016/j.jad.2009.10.023. Epub 2009 Nov 14
Kanemura H, Sano F, Maeda Y, Sugita K, Aihara M. Valproate sodium enhances body weight gain in patients with childhood epilepsy: a pathogenic mechanisms and open-label clinical trial of behavior therapy. Seizure. 2012;21(7):496–500. https://doi.org/10.1016/j.seizure.2012.05.001. Epub 2012 Jun 12
Torrent C, Amann B, Sanchez-Moreno J, Colom F, Reinares M, Comes M, Rosa AR, Scott J, Vieta E. Weight gain in bipolar disorder: pharmacological treatment as a contributing factor. Acta Psychiatr Scand. 2008;118:4–18.
McElroy SL, Keck PE Jr. Obesity in bipolar disorder: an overview. Curr Psychiatry Rep. 2012;14:650–8.
McElroy SL, Crow S, Cuellar-Barboza AB, Prieto ML, Veldic M, Winham SJ, Bobo WV, Geske J, Seymour LR, Mori N, Bond DJ, Biernacka JM, Frye MA. Clinical features of bipolar spectrum with binge eating behaviour. J Affect Disord. 2016;201:95–8.
Uguz F, Sahingoz M, Gungor B, Aksoy F, Askin R. Weight gain and associated factors in patients using newer antidepressant drugs. Gen Hosp Psychiatry. 2015;37(1):46–8. https://doi.org/10.1016/j.genhosppsych.2014.10.011. Epub 2014 Oct 31
McElroy SL, Guerdjikova AI, Mori N, Keck PE. Managing comorbid obesity and depression through clinical pharmacotherapies. Expert Opin Pharmacother. 2016;17(12):1599–610.
Kirkham T. Endocannabinoids and the neurochemistry of gluttony. J Neuroendocrinol. 2008;20:1099–100.
Hirsch S, Tam J. Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome. Toxins. 2019;11:275.
Tarragon E, Moreno JJ. Cannabinoids, chemical senses, and regulation of feeding behavior. Chem Senses. 2019;44(2):73–89. https://doi.org/10.1093/chemse/bjy068.
Verrotti A, Scaparrotta A, Agostinelli S, Di Pillo S, Chiarelli F, Grosso S. Topiramate-induced weight loss: a review. Epilepsy Res. 2011;95:189–99.
Kushner RF. Weight loss strategies for treatment of obesity: lifestyle management and pharmacotherapy. Prog Cardiovasc Dis. 2018;61:246–52.
Arterburn D, Sofer T, Boudreau DM, Bogart A, Westbrook EO, Theis MK, Simon G, Haneuse S. Long-term weight change after initiating second-generation antidepressants. J Clin Med. 2016;5(4)
Serralde-Zúñiga AE, Gonzalez Garay AG, RodrÃguez-Carmona Y, Melendez G. Fluoxetine for adults who are overweight or obese. Cochrane Database Syst Rev. 2019;10:CD011688. https://doi.org/10.1002/14651858.CD011688.pub2. [Epub ahead of print] Review.
Krentz AJ, Fujioka K, Hompesch M. Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles. Diabetes Obes Metab. 2016;18(6):558–70. https://doi.org/10.1111/dom.12657. Review.
Fulp A, Zhang Y, Bortoff K, Seltzman H, Snyder R, Wiethe R, Amato G, Maitra R. Pyrazole antagonists of the CB1 receptor with reduced brain penetration. Bioorg Med Chem. 2016;24:1063–70.
Saunders KH, Umashanker D, Igel LI, Kumar RB, Aronne LJ. Obesity pharmacotherapy. Med Clin North Am. 2018;102(1):135–48.
Amodeo G, Cuomo A, Bolognesi S, Goracci A, Trusso MA, Piccinni A, Neal SM, Baldini I, Federico E, Taddeucci C, Fagiolini A. Pharmacotherapeutic strategies for treating binge eating disorder. Evidence from clinical trials and implications for clinical practice. Expert Opin Pharmacother. 2019;20(6):679–90. https://doi.org/10.1080/14656566.2019.1571041. Epub 2019 Jan 29. Review.
Bernet VJ. Thyroid hormone misuse and abuse. Endocrine. 2019;66:79–86.
Cochrane C, Malcolm R, Brewerton T. The role of weight control as a motivation for cocaine abuse. Addict Behav. 1998;23(2):201–7.
Vicentic A, Jones DC. The CART (cocaine- and amphetamine-regulated transcript) system in appetite and drug addiction. J Pharmacol Exp Ther. 2007;320(2):499–506. Epub 2006 Jul 13.
Ersche KD, Stochl J, Woodward JM, Fletcher PC. The skinny on cocaine: insights into eating behavior and body weight in cocaine-dependent men. Appetite. 2013;71:75–80. https://doi.org/10.1016/j.appet.2013.07.011. Epub 2013 Aug 3.
Neale J, Nettleton S, Pickering L, Fischer J. Eating patterns among heroin users: a qualitative study with implications for nutritional interventions. Addiction. 2012;107(3):635–41.
McIlwraith F, Betts KS, Jenkinson R, Hickey S, Burns L, Alati R. Is low BMI associated with specific drug use among injecting drug users? Subst Use Misuse. 2014;49(4):374–82.
Mysels DJ, Sullivan MA. The relationship between opioid and sugar intake: review of evidence and clinical applications. J Opioid Manag. 2010;6(6):445–52.
Pereska Z, Bozinovska C, Dimitrovski C, Cakalarovski K, Chibishev A, Zdravkovska M, Babulovska A, Janicevic D. Heroin dependence duration influences the metabolic parameters: mechanisms and consequences of impaired insulin sensitivity in hepatitis C virus seronegative heroin dependents. J Addict Med. 2012;6(4):304–10. https://doi.org/10.1097/ADM.0b013e31826bd76c.
Levine AS, Grace M, Billington CJ. The effect of centrally administered naloxone on deprivation and drug-induced feeding. Pharmacol Biochem Behav. 1990;36(2):409–12.
Peles E, Schreiber S, Sason A, Adelson M. Risk factors for weight gain during methadone maintenance treatment. Subst Abus. 2016;37(4):613–8.
Hu T, Yang Z, Li MD. Pharmacological effects and regulatory mechanisms of tobacco smoking effects on food intake and weight control. J Neuroimmune Pharmacol. 2018;13:453.
Chawla N, Charan D, Kumar S, Pattanayak RD. Pica associated with initiation of atypical antipsychotic drugs: Report of two cases. Psychiatry Clin Neurosci. 2016;70(8):363–4.
Huang JH, Shiah IS, Lee WK, Tzang RF, Chang KJ. Olanzapine-associated pica in a schizophrenia patient. Psychiatry Clin Neurosci. 2010;64(4):444.
Chawla N, Mandal P, Chatterjee B, Dhawan A. Tramadol-associated pica. Psychiatry Clin Neurosci. 2019;73(1):43.
Nzwalo H, Ferreira L, Peralta R, Bentes C. Sleep-related eating disorder secondary to zolpidem. BMJ Case Rep. 2013:2013.
Müller TD, Clemmensen C, Finan B, DiMarchi RD, Tschöp MH. Anti-obesity therapy: from rainbow pills to polyagonists. Pharmacol Rev. 2018;70(4):712–46.
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Marzola, E., Musso, M., Abbate-Daga, G. (2022). Psychotropic Drug-Induced Disordered Eating Behaviors. In: Manzato, E., Cuzzolaro, M., Donini, L.M. (eds) Hidden and Lesser-known Disordered Eating Behaviors in Medical and Psychiatric Conditions . Springer, Cham. https://doi.org/10.1007/978-3-030-81174-7_8
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DOI: https://doi.org/10.1007/978-3-030-81174-7_8
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