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The Seminiferous Epithelial Cycle of Spermatogenesis: Role of Non-receptor Tyrosine Kinases

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Molecular Mechanisms in Spermatogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1381))

Abstract

Non-receptor tyrosine kinases (NRTKs) are implicated in various biological processes including cell proliferation, differentiation, survival, and apoptosis, as well as cell adhesion and movement. NRTKs are expressed in all mammals and in different cell types, with extraordinarily high expression in the testis. Their association with the plasma membrane and dynamic subcellular localization are crucial parameters in their activation and function. Many NRTKs are found in endosomal protein trafficking pathways, which suggests a novel mechanism to regulate the timely junction restructuring in the mammalian testis to facilitate spermiation and germ cell transport across the seminiferous epithelium.

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Acknowledgments

This work was supported by grants from the National Key Research and Development Program of China (2018YFC1003504), National Natural Science Foundation of China (31371176, 81771647, 81502794 and 81973011), Zhejiang Provincial Natural Science Foundation of China (LY21H040005), Zhejiang Provincial Department of Education (Y202045395), Health Commission of Zhejiang Province (2020RC052).

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Authors and Affiliations

  1. Institute for Reproductive Health, Hangzhou Medical College (Zhejiang Academy of Medical Sciences), Hangzhou, Zhejiang, China

    Xiang Xiao, Dongwang Zheng, Fei Liang, Peibei Sun, Jianmin Yu & Ya Ni

  2. Institute of Occupation Diseases, Hangzhou Medical College (Zhejiang Academy of Medical Sciences), Hangzhou, Zhejiang, China

    Shibo Ying

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  1. Xiang Xiao
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  2. Dongwang Zheng
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  4. Shibo Ying
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  6. Jianmin Yu
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  7. Ya Ni
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Correspondence to Xiang Xiao .

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  1. Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    C.Yan Cheng

  2. Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Fei Sun

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Xiao, X. et al. (2021). The Seminiferous Epithelial Cycle of Spermatogenesis: Role of Non-receptor Tyrosine Kinases. In: Cheng, C., Sun, F. (eds) Molecular Mechanisms in Spermatogenesis. Advances in Experimental Medicine and Biology, vol 1381. Springer, Cham. https://doi.org/10.1007/978-3-030-77779-1_1

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