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tDCS-Pharmacotherapy Interactions

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Transcranial Direct Current Stimulation in Neuropsychiatric Disorders

Abstract

Transcranial direct current stimulation (tDCS) noninvasively induces cortical excitability alterations via application of continuous, weak direct current through the scalp and has been adopted in clinical settings, particularly in psychiatry, as adjunctive treatment option. This chapter discusses the interaction between tDCS and application of pharmacological agents relevant for psychiatric disorders. It covers the underlying neurochemistry associated with tDCS mechanisms of action, as well as the alteration of tDCS effects, namely neuroplasticity, via major neuromodulator systems, including dopamine, acetylcholine, serotonin, and noradrenaline, which are involved in various psychiatric disorders, and also targets for pharmacological interventions. Furthermore, this chapter addresses the clinical relevance of the interplay between tDCS and corresponding pharmacological agents , to supply the reader with an overview for further implementation of the technique from bench to bedside.

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  • 10 November 2021

    A correction has been published.

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Authors and Affiliations

  1. Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany

    Min-Fang Kuo & Michael A. Nitsche

  2. Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany

    Michael A. Nitsche

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  1. Min-Fang Kuo
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  2. Michael A. Nitsche
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Correspondence to Michael A. Nitsche .

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Editors and Affiliations

  1. Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    André R. Brunoni

  2. Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany

    Michael A. Nitsche

  3. Black Dog Institute & School of Psychiatry, University of New South Wales, Sydney, Australia

    Colleen K. Loo

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Kuo, MF., Nitsche, M.A. (2021). tDCS-Pharmacotherapy Interactions. In: Brunoni, A.R., Nitsche, M.A., Loo, C.K. (eds) Transcranial Direct Current Stimulation in Neuropsychiatric Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-76136-3_38

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