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Higher Plant Sources of Cancer Chemotherapeutic Agents and the Potential Role of Biotechnological Approaches for Their Supply

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Medicinal Plants

Part of the book series: Sustainable Development and Biodiversity ((SDEB,volume 28))

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Abstract

There are five major structural groups of cancer chemotherapeutic agents derived from higher plants approved clinically in the USA. These are used either in their unmodified naturally occurring form, as semi-synthetic derivatives, or as a conjugate as part of a larger drug molecule. In this chapter, those compounds used currently as approved oncolytic drugs will be described, following by a brief mention of selected plant-derived compounds in current clinical trials as potential cancer chemotherapeutic agents. Next, details on the methods proposed for the production for the oncology drug market of three examples of different structural groups of plant-derived anticancer agents will be given [viz., bisindole (Vinca) alkaloids, podophyllotoxin lignan analogs, and taxane diterpenoid derivatives]. The plant natural products surveyed represent sustainable sources of specialized pure chemicals that are valuable in treating cancer.

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Acknowledgements

Research conducted in our own laboratory directed toward the discovery of new anticancer agents from higher plants and other organism has been funded through program project P01 CA125066 by the U.S. National Cancer Institute, NIH, Bethesda, MD, USA.

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Authors and Affiliations

  1. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA

    Peter J. Blanco Carcache, Ermias Mekuria Addo & A. Douglas Kinghorn

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  1. Peter J. Blanco Carcache
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  2. Ermias Mekuria Addo
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  3. A. Douglas Kinghorn
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Correspondence to A. Douglas Kinghorn .

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Editors and Affiliations

  1. Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Kraków, Poland

    Halina Maria Ekiert

  2. Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, India

    Kishan Gopal Ramawat

  3. Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, India

    Jaya Arora

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Blanco Carcache, P.J., Addo, E.M., Kinghorn, A.D. (2021). Higher Plant Sources of Cancer Chemotherapeutic Agents and the Potential Role of Biotechnological Approaches for Their Supply. In: Ekiert, H.M., Ramawat, K.G., Arora, J. (eds) Medicinal Plants. Sustainable Development and Biodiversity, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-030-74779-4_17

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