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NGF Signaling in Endosomes

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Recent Advances in NGF and Related Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((CNNCSN,volume 1331))

Abstract

During the development of the nervous system, neurons respond to diffusible cues secreted by target cells. Because such target-derived factors regulate development, maturation, and maintenance of axons as well as somatodendritic compartments, signals initiated at distal axons must be retrogradely transmitted toward cell bodies. Neurotrophins, including the nerve growth factor (NGF), provide one of the best-known examples of target-derived growth factors. The cell biological processes of endocytosis and retrograde trafficking of their Trk receptors from growth cones to cell bodies are key mechanisms by which target-derived neurotrophins influence neurons. Evidence accumulated over the past several decades has begun to uncover the molecular mechanisms of formation, transport, and biological functions of these specialized endosomes called “signaling endosomes.”

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Acknowledgments

The author’s work was supported by the Naito Foundation, the Ichiro Kanehara Foundation, the Daiichi Sankyo Foundation of Life Science, MEXT/JSPS KAKENHI (20K07742), and the Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine.

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  1. Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan

    Naoya Yamashita

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  1. Naoya Yamashita
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Correspondence to Naoya Yamashita .

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Editors and Affiliations

  1. University of Bologna, Ozzano dell’Emilia, Bologna, Italy

    Laura Calzà

  2. IRET Foundation, Ozzano dell’Emilia, Bologna, Italy

    Luigi Aloe

  3. University of Bologna, Ozzano dell’Emilia, Bologna, Italy

    Luciana Giardino

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Yamashita, N. (2021). NGF Signaling in Endosomes. In: Calzà, L., Aloe, L., Giardino, L. (eds) Recent Advances in NGF and Related Molecules. Advances in Experimental Medicine and Biology(), vol 1331. Springer, Cham. https://doi.org/10.1007/978-3-030-74046-7_3

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