Abstract
Aim/Background: This chapter will address the clinical challenges of COVID-19 through the lens of informatics, detailing examples of how these challenges have been tackled.
COVID-19 emerged from Wuhan, China, in late 2019. A new strain of coronavirus was not previously identified in humans. Coronaviruses are a large family of viruses which cause illness ranging from a mild cold to severe disease. Since the alarm was first raised in China, COVID-19 spread rapidly throughout the globe. Initially deemed as a ‘Public Health Emergency of International Concern’ by the World Health Organization (WHO), it was later declared a pandemic on March 11, 2020.
Nations have been striving to ‘flatten the curve’, so as to reduce the burden on healthcare systems and reduce the number of deaths. Globally we have had to get to grip with diagnosing, treating, and navigating this novel coronavirus path in a time-critical manner.
Methods: Informed by a retrospective review of the body of COVID-19 literature, first-hand clinical experience and overarching public and global health principles, we propose the key clinical challenges faced in the fight against COVID-19. These will be explored, with current and potential informatics solutions elaborated upon. We will study healthcare systems and how information has been transformed within these during the pandemic.
Results: We have identified key clinical challenges faced in the wake of COVID-19. These challenges invariably vary between countries; however, no country has been without challenge. The key challenges identified were testing and laboratory capacity; understanding presentations of COVID-19; rapid formulation of treatment guidelines and dissemination of these; contact tracing; use of technology for communication; human resources; personal protective equipment supplies; information sharing within the scientific community; running clinical trials; finding a vaccine; increasing hospital capacity; ensuring appropriate use of healthcare facilities; secondary impacts, e.g. delayed presentation; misinformation; use of infographics; training of healthcare professionals; performing aerosol-generating procedures; and quarantining clinical areas.
Conclusions: In the midst of a global health emergency, we have identified and addressed many clinical challenges. We have adapted rapidly out of necessity. Lessons have been learned, and future challenges will arise. We must reflect on our progress and failings thus far, to ensure maximum learning. Recommendations for future pandemics are open information sharing, knowledge hubs which are easily accessible, a continuous commitment to analyse and learn from our actions and the pursuit of innovative solutions utilising informatics.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
S. Perlman, J. Netland, Coronaviruses post-SARS: Update on replication and pathogenesis. Nat. Rev. Microbiol. 7(6), 439–450 (2009)
M. Lotfi et al., COVID-19: Transmission, prevention, and potential therapeutic opportunities. Clin. Chim. Acta 508, 254–266 (2020)
Cochrane COVID-19 study register, https://covid-19.cochrane.org/. Last updated 28 Apr 2020. Accessed 28 Apr 2020
R. Lu, X. Zhao, J. Li, P. Niu, B. Yang, H. Wu, W. Wang, H. Song, B. Huang, N. Zhu, et al., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet 395, 565–574 (2020)
N. van Doremalen et al., Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N. Engl. J. Med. 382, 1564–1567 (2020)
N. Chen, M. Zhou, X. Dong, J. Qu, F. Gong, Y. Han, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 395(10223), 507–513 (2020)
A.R. Sahin, A. Erdogan, P.M. Agaoglu, Y. Dineri, A.Y. Cakirci, M.E. Senel, 2019 Novel coronavirus (COVID-19) outbreak: A review of the current literature. EJMO 4(1), 1–7 (2020)
C. Rothe, M. Schunk, P. Sothmann, G. Bretzel, G. Froeschl, C. Wallrauch, Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N. Engl. J. Med. 382(10), 970–971 (2020)
K. McIntosh, M.S. Hirsch, A. Bloom, Coronavirus disease 2019 (COVID-19), in UpToDate, ed. by M. S. Hirsch, A. Bloom, Accessed 5 Mar 2020
D. Headey, Impacts of COVID-19 on childhood malnutrition and nutrition-related mortality. Lancet 396(10250), 519–521 (2020)
F. Pan, T. Ye, P. Sun, S. Gui, B. Liang, L. Li, et al., Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology 295(3), 715–721 (2020)
N. Chen et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 395(10223), 507–513 (2020)
World Health Organization, WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 Mar 2020, https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19%2D%2D-11-march-2020
https://www.cdc.gov/coronavirus/2019-ncov/global-covid-19/pre-deployment-processes-COVID-19-considerations.html. Accessed 20 Jan 2021
M.D. Fei Zhou, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 395(10229), 1054–1062 (2020)
F. Jiang, Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). J. Gen. Intern. Med. 35(5), 1545–1549 (2020)
L. Guo, Clinical features predicting mortality risk in patients with viral pneumonia: The MuLBSTA score. Front. Microbiol 10, 2752 (2019)
P.M. Folegatti et al., Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: A preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet 396(10249), 467–478 (2020)
M.D. Fujun Peng, Management and treatment of COVID-19: The Chinese experience. Can. J. Cardiol. 36(6), 915–930 (2020)
D. Tan, COVID-19 Ring-Based Prevention Trial with Lopinavir/Ritonavir (CORIPREV-LR) (St. Michael’s Hospital, Toronto)
S. Mahendiratta, Molecular diagnosis of COVID-19 in the different biologic matrix, their diagnostic validity and clinical relevance: A systematic review. Life Sci. 258, 118207 (2020)
N. Madhav, B. Oppenheim, M. Gallivan, P. Mulembakani, E. Rubin, N. Wolfe, Chapter 17: Pandemics: Risks, impacts, and mitigation, in Disease Control Priorities: Improving Health and Reducing Poverty, 3rd edn., (The World Bank Group, Washington)
A. Kumar, A review of modern technologies for tackling COVID-19 pandemic. Diabet. Metab. Syndr. 14(4), 569–573 (2020)
D.S.W. Ting, Digital technology and COVID-19. Nat. Med. 26, 1–3 (2020)
M. Saiful Islam et al., Current knowledge of COVID-19 and infection prevention and control strategies in healthcare settings: A global analysis. Infect. Control Hosp. Epidemiol. 15, 1–11 (2020)
C. Maringe et al., The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: A national, population-based, modelling study. Lancet 21(8), 1023–1034 (2020)
https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pd. Accessed 20 Jan 2021
S.M. Lemon et al., Ethical and Legal Considerations in Mitigating Pandemic Disease: Workshop Summary (Institute of Medicine (US) Forum on Microbial Threats, National Academies Press, Washington, DC, 2007)
I. Rudan, A cascade of causes that led to the COVID-19 tragedy in Italy and other European Union countries. J. Glob. Health 10(1), 010335 (2020)
A. Clark, M. Jit, C. Warren-Gash, B. Guthrie, H.H.X. Wang, S.W. Mercer, C. Sanderson, M. McKee, C. Troeger, K.L. Ong, F. Checchi, P. Perel, S. Joseph, H.P. Gibbs, A. Banerjee, R.M. Eggo, Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group, Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study. Lancet Glob. Health (2020)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Kadri, S.M., Mattoo, S., Brady, A.H., Petkovic, M. (2022). Innovative Solutions to the Clinical Challenges of COVID-19. In: Garg, L., Chakraborty, C., Mahmoudi, S., Sohmen, V.S. (eds) Healthcare Informatics for Fighting COVID-19 and Future Epidemics. EAI/Springer Innovations in Communication and Computing. Springer, Cham. https://doi.org/10.1007/978-3-030-72752-9_17
Download citation
DOI: https://doi.org/10.1007/978-3-030-72752-9_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-72751-2
Online ISBN: 978-3-030-72752-9
eBook Packages: EngineeringEngineering (R0)