Abstract
Esophageal occult bleeding represents an important subset of occult gastrointestinal (GI) bleeding. Gastroenterologists and primary care physicians need to be aware of the causes of esophageal bleeding, their presentations and how to manage these patients in timely and effective manner. The upper GI tract bleeding is estimated to account for 37% of occult GI bleeding with esophagitis alone accounting for 19%. The prevalence of reflux esophagitis cannot be determined accurately as many patients may be asymptomatic and some symptomatic patients may not seek medical attention due to mild symptoms. Esophageal carcinomas are also an important cause of occult GI bleeding. Particularly, patients with longstanding reflux esophagitis are predisposed to esophageal adenocarcinoma. It seems that a prolonged exposure to gastric acidity slowly transforms the mucosa in the lower third of the esophagus into a metaplastic, and later dysplastic tissue. Other primary esophageal malignancies can lead to occult bleeding. It is also important to recognize esophageal varices in cirrhotic patients. Esophageal varices usually present as melena or hematemesis. However, patients may have recurrent melena that goes unnoticed or is ignored by the patient and may present later with iron deficiency anemia. Esophageal causes of occult GI bleeding should be considered in patients with dysphagia, odynophagia, nausea, epigastric pain, atypical chest pain, heartburn, regurgitation, hiccups, chronic chough, hoarseness, sore throat, and unexplained weight loss.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Mitchell SH, Schaefer DC, Dubagunta S. A new view of occult and obscure gastrointestinal bleeding. Am Fam Physician. 2004;69(4):875–81.
Bloem BR, et al. Prevalence of subjective dysphagia in community residents aged over 87. BMJ. 1990;300(6726):721–2.
Locke GR 3rd, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112(5):1448–56.
Bredenoord AJ. Mechanisms of reflux perception in gastroesophageal reflux disease: a review. Am J Gastroenterol. 2012;107(1):8–15.
Johnson DA, Fennerty MB. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease. Gastroenterology. 2004;126(3):660–4.
Peery AF, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143(5):1179–87. e3
Song HJ, et al. The prevalence and clinical characteristics of reflux esophagitis in Koreans and its possible relation to metabolic syndrome. J Korean Med Sci. 2009;24(2):197–202.
Zuckerman GR, et al. AGA technical review on the evaluation and management of occult and obscure gastrointestinal bleeding. Gastroenterology. 2000;118(1):201–21.
Wang FW, et al. Erosive esophagitis in asymptomatic subjects: risk factors. Dig Dis Sci. 2010;55(5):1320–4.
Richter JE, Bradley LA, Castell DO. Esophageal chest pain: current controversies in pathogenesis, diagnosis, and therapy. Ann Intern Med. 1989;110(1):66–78.
Smith JA, Abdulqawi R, Houghton LA. GERD-related cough: pathophysiology and diagnostic approach. Curr Gastroenterol Rep. 2011;13(3):247–56.
Sakaguchi M, et al. Factors associated with complicated erosive esophagitis: a Japanese multicenter, prospective, cross-sectional study. World J Gastroenterol. 2017;23(2):318–27.
Lundell LR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45(2):172–80.
Ness-Jensen E, et al. Tobacco smoking cessation and improved gastroesophageal reflux: a prospective population-based cohort study: the HUNT study. Am J Gastroenterol. 2014;109(2):171–7.
Ness-Jensen E, et al. Lifestyle Intervention in Gastroesophageal Reflux Disease. Clin Gastroenterol Hepatol. 2016;14(2):175–82. e1–3
Kinoshita Y, Hongo M, Japan TSG. Efficacy of twice-daily rabeprazole for reflux esophagitis patients refractory to standard once-daily administration of PPI: the Japan-based TWICE study. Am J Gastroenterol. 2012;107(4):522–30.
Weijenborg PW, et al. PPI therapy is equally effective in well-defined non-erosive reflux disease and in reflux esophagitis: a meta-analysis. Neurogastroenterol Motil. 2012;24(8):747–57, e350
Chiba N, et al. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology. 1997;112(6):1798–810.
Samuel R, et al. Evaluation and management of non-variceal upper gastrointestinal bleeding. Dis Mon. 2018;64(7):333–43.
Marmo R, et al. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol. 2007;102(2):279–89; quiz 469
Laine L, McQuaid KR. Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials. Clin Gastroenterol Hepatol. 2009;7(1):33–47; quiz 1–2
Stefanidis D, et al. Guidelines for surgical treatment of gastroesophageal reflux disease. Surg Endosc. 2010;24(11):2647–69.
Rakita S, et al. Laparoscopic Nissen fundoplication offers high patient satisfaction with relief of extraesophageal symptoms of gastroesophageal reflux disease. Am Surg. 2006;72(3):207–12.
Oelschlager BK, et al. Symptomatic and physiologic outcomes after operative treatment for extraesophageal reflux. Surg Endosc. 2002;16(7):1032–6.
Ramanathan J, et al. Herpes simplex virus esophagitis in the immunocompetent host: an overview. Am J Gastroenterol. 2000;95(9):2171–6.
Kato S, et al. Herpes simplex esophagitis in the immunocompetent host. Dis Esophagus. 2005;18(5):340–4.
Lee B, Caddy G. A rare cause of dysphagia: herpes simplex esophagitis. World J Gastroenterol. 2007;13(19):2756–7.
de-la-Riva, S., et al. Herpetic esophagitis: a case report on an immunocompetent adolescent. Rev Esp Enferm Dig. 2012;104(4):214–7.
Bando T, et al. Herpes simplex esophagitis in the elderly. Dig Endosc. 2009;21(3):205–7.
Badarinarayanan G, Gowrisankar R, Muthulakshmi K. Esophageal candidiasis in non-immune suppressed patients in a semi-urban town, southern India. Mycopathologia. 2000;149(1):1–4.
Andersen LI, Frederiksen HJ, Appleyard M. Prevalence of esophageal Candida colonization in a Danish population: special reference to esophageal symptoms, benign esophageal disorders, and pulmonary disease. J Infect Dis. 1992;165(2):389–92.
Learmonth I, Weaver PC. Letter: potassium stricture of the upper alimentary tract. Lancet. 1976;1(7953):251–2.
Peters JL. Benign oesophageal stricture following oral potassium chloride therapy. Br J Surg. 1976;63(9):698–9.
Wong RK, Kikendall JW, Dachman AH. Quinaglute-induced esophagitis mimicking an esophageal mass. Ann Intern Med. 1986;105(1):62–3.
Abbarah TR, Fredell JE, Ellenz GB. Ulceration by oral ferrous sulfate. JAMA. 1976;236(20):2320.
Stoller JL. Oesophageal ulceration and theophylline. Lancet. 1985;2(8450):328–9.
Enzenauer RW, Bass JW, McDonnell JT. Esophageal ulceration associated with oral theophylline. N Engl J Med. 1984;310(4):261.
Oren R, Fich A. Oral contraceptive-induced esophageal ulcer. Two cases and literature review. Dig Dis Sci. 1991;36(10):1489–90.
Bova JG, et al. Medication-induced esophagitis: diagnosis by double-contrast esophagography. AJR Am J Roentgenol. 1987;148(4):731–2.
Nguyen T, et al. Mycophenolic acid (cellcept and myofortic) induced injury of the upper GI tract. Am J Surg Pathol. 2009;33(9):1355–63.
Perry PA, Dean BS, Krenzelok EP. Drug induced esophageal injury. J Toxicol Clin Toxicol. 1989;27(4–5):281–6.
Katzka DA. Esophageal disorders caused by medications, trauma, and infection. In: Friedman LFM, Brandt LJ, editors. Sleisenger and Fordtran’s gastrointestinal and liver disease: Saunders Elsevier; 2010. p. 763–72.
Ribeiro A, et al. Alendronate-associated esophagitis: endoscopic and pathologic features. Gastrointest Endosc. 1998;47(6):525–8.
Abraham SC, et al. Upper gastrointestinal tract injury in patients receiving kayexalate (sodium polystyrene sulfonate) in sorbitol: clinical, endoscopic, and histopathologic findings. Am J Surg Pathol. 2001;25(5):637–44.
Purdy JK, Appelman HD, McKenna BJ. Sloughing esophagitis is associated with chronic debilitation and medications that injure the esophageal mucosa. Mod Pathol. 2012;25(5):767–75.
Ravich WJ, Kashima H, Donner MW. Drug-induced esophagitis simulating esophageal carcinoma. Dysphagia. 1986;1(1):13–8.
Creteur V, et al. Drug-induced esophagitis detected by double-contrast radiography. Radiology. 1983;147(2):365–8.
Agha FP, Wilson JA, Nostrand TT. Medication-induced esophagitis. Gastrointest Radiol. 1986;11(1):7–11.
Jung BH. Gastrointestinal cancers. In: Sweetser S, editor. Digestive disease self-education program: American Gastroenterological Association: American Gastroenterological Association; 2016. p. 433–6.
Rubenstein JH, Shaheen NJ. Epidemiology, diagnosis, and management of esophageal adenocarcinoma. Gastroenterology. 2015;149(2):302–17. e1
Abnet CC, Arnold M, Wei WQ. Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 2018;154(2):360–73.
Sohda M, Kuwano H. Current status and future prospects for esophageal cancer treatment. Ann Thorac Cardiovasc Surg. 2017;23(1):1–11.
Wang KK, Wongkeesong M, Buttar NS. American Gastroenterological Association technical review on the role of the gastroenterologist in the management of esophageal carcinoma. Gastroenterology. 2005;128(5):1471–505.
Aziz M, et al. Efficacy of Hemospray in non-variceal upper gastrointestinal bleeding: a systematic review with meta-analysis. Ann Gastroenterol. 2020;33(2):145–54.
Inayat F, et al. Primary esophageal diffuse large B-Cell lymphoma: a comparative review of 15 cases. J Investig Med High Impact Case Rep. 2018;6:2324709618820887.
Schatz RA, Rockey DC. Gastrointestinal bleeding due to gastrointestinal tract malignancy: natural history, management, and outcomes. Dig Dis Sci. 2017;62(2):491–501.
Pellecchia R, et al. An esophageal lymphoma discovered by echocardiography. Rev Port Cardiol. 2016;35(6):381–2.
Mrad RA, et al. The elusive diagnosis of primary esophageal lymphoma. Turk J Haematol. 2018;35(3):199.
Theiss L, Contreras CM. Gastrointestinal stromal tumors of the stomach and esophagus. Surg Clin North Am. 2019;99(3):543–53.
Cohen C, et al. Is there a place for thoracoscopic enucleation of esophageal gastrointestinal stromal tumors? Thorac Cardiovasc Surg. 2019;67(7):585–8.
Baysal B, et al. The role of EUS and EUS-guided FNA in the management of subepithelial lesions of the esophagus: a large, single-center experience. Endosc Ultrasound. 2017;6(5):308–16.
Hihara J, Mukaida H, Hirabayashi N. Gastrointestinal stromal tumor of the esophagus: current issues of diagnosis, surgery and drug therapy. Transl Gastro Hepatol. 2018;3:6.
Ma Z, Cai H, Cui Y. Progress in the treatment of esophageal neuroendocrine carcinoma. Tumour Biol. 2017;39(6):1010428317711313.
Schizas D, et al. Neuroendocrine tumors of the esophagus: state of the art in diagnostic and therapeutic management. J Gastrointest Cancer. 2017;48(4):299–304.
Nagtegaal ID, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76(2):182–8.
Giannetta E, et al. A rare rarity: neuroendocrine tumor of the esophagus. Crit Rev Oncol Hematol. 2019;137:92–107.
Farley HA, Pommier RF. Surgical treatment of small bowel neuroendocrine tumors. Hematol Oncol Clin North Am. 2016;30(1):49–61.
van der Veen A, et al. Management of resectable esophageal and gastric (mixed adeno)neuroendocrine carcinoma: a nationwide cohort study. Eur J Surg Oncol. 2018;44(12):1955–62.
Scaglione S, et al. The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol. 2015;49(8):690–6.
Garcia-Tsao G, et al. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46(3):922–38.
Naveau S, Perlemuter G, Balian A. Epidemiology and natural history of cirrhosis. Rev Prat. 2005;55(14):1527–32.
Gkamprela E, Deutsch M, Pectasides D. Iron deficiency anemia in chronic liver disease: etiopathogenesis, diagnosis and treatment. Ann Gastroenterol. 2017;30(4):405–13.
Grace ND. Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension. American College of Gastroenterology Practice Parameters Committee. Am J Gastroenterol. 1997;92(7):1081–91.
de Franchis R, Baveno VIF. Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015;63(3):743–52.
Saeed ZA, et al. Endoscopic variceal ligation in patients who have failed endoscopic sclerotherapy. Gastrointest Endosc. 1990;36(6):572–4.
Je D, et al. The comparison of esophageal variceal ligation plus propranolol versus propranolol alone for the primary prophylaxis of esophageal variceal bleeding. Clin Mol Hepatol. 2014;20(3):283–90.
Zhu Y, et al. Emergency transjugular intrahepatic portosystemic shunt: an effective and safe treatment for uncontrolled variceal bleeding. J Gastrointest Surg. 2019;23(11):2193–200.
Orchard JL, et al. Upper gastrointestinal tract bleeding in institutionalized mentally retarded adults. Primary role of esophagitis. Arch Fam Med. 1995;4(1):30–3.
Gupta N, et al. Longer inspection time is associated with increased detection of high-grade dysplasia and esophageal adenocarcinoma in Barrett’s esophagus. Gastrointest Endosc. 2012;76(3):531–8.
Everson MA, et al. How to perform a high-quality examination in patients with Barrett’s esophagus. Gastroenterology. 2018;154(5):1222–6.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Tageldin, O., Shah, V., Kalakota, N., Lee, H., Tadros, M., Litynski, J. (2021). Esophagus. In: Tadros, M., Wu, G.Y. (eds) Management of Occult GI Bleeding. Clinical Gastroenterology. Humana, Cham. https://doi.org/10.1007/978-3-030-71468-0_5
Download citation
DOI: https://doi.org/10.1007/978-3-030-71468-0_5
Published:
Publisher Name: Humana, Cham
Print ISBN: 978-3-030-71467-3
Online ISBN: 978-3-030-71468-0
eBook Packages: MedicineMedicine (R0)