Abstract
Purpose: The aim of the study is to monitor the safety of preventive chemotherapy in children with latent tuberculosis infection using various combinations of anti-tuberculosis drugs.
Design/Methodology/Approach: The study included 180 children aged from 1 to 17 years of age from high-risk groups of the development of tuberculosis without clinical and radiological signs of the disease. The ratio of boys to girls was 57.8% and 42.2%. Children aged 1–6 years were 43 people (23.8%), 7–14 years – 92 people (51.1%), 15–17 years – 45 people (25.0%). Children received various combinations of anti-TB drugs: isoniazid and rifampicin (HR) took 4 children, isoniazid with pyrazinamide (HZ) – 132 people, isoniazid and ethambutol (NE) received 21 people, isoniazid and rifapentine (HRpt) – 23 people. The duration of treatment for 80 children (44.4%) was 3 months, for 100 children (55.6%) – 6 months.
Findings: The use of a combination of drugs isoniazid and rifapentine (HRpt) indicates lower toxicity of the regimen than other used regimens, which allows children to complete a course of preventive chemotherapy. In the HR scheme, adverse events occurred in 50% of cases, in the HZ and NE scheme – in 14.4 and 14.3% of cases (respectively), in the HRpt scheme – only in 4.3% of cases (p < 0.05).
Originality/Value: The author established in the course of research that the plan for preventive chemotherapy - isoniazid in combination with rifapentine was safe for children, since it was not accompanied by the development of serious adverse events that required the cancellation of anti-TB drugs.
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Baronova, O.D. (2021). Safety Monitoring of Preventive Chemotherapy in Children with Latent Tuberculosis Infection in the Stavropol Territory. In: Popkova, E.G., Sergi, B.S. (eds) Modern Global Economic System: Evolutional Development vs. Revolutionary Leap. ISC 2019. Lecture Notes in Networks and Systems, vol 198. Springer, Cham. https://doi.org/10.1007/978-3-030-69415-9_73
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