Abstract
Aging population presents a major public health challenge across developed societies. Since phytobioactive compounds (PBCs) including resveratrol, quercetin, curcumin, catechin, and epigallocatechin-3-gallate have been repeatedly reported to demonstrate anti-aging properties, they are increasingly investigated for their anti-aging potential now. The therapeutic efficiency of orally administered PBCs is, however, largely limited by their poor stability, solubility in the gastrointestinal tract, and, subsequently, bioavailability. Apart from the use of polymeric nanoparticles in therapeutics delivery as depicted in Section II, biomaterials have been widely used as drug carriers. One of these biomaterials is lipids, which are a large and diverse group of naturally occurring organic compounds important to cell physiology. It has been reported that PBC-loaded lipid nanocomposites provide many benefits over their conventional formulations, including improved solubility and stability, prolonged half-life, enhanced epithelium permeability and bioavailability, and also improved tissue targeting and minimized side effects. This chapter will summarize recent advances in this research area.
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Ahangarpour A, Oroojan AA, Khorsandi L, Kouchak M, Badavi M (2019) Hyperglycemia-induced oxidative stress in isolated proximal tubules of mouse: the in vitro effects of myricitrin and its solid lipid nanoparticle. Arch Physiol Biochem 1:1–7. https://doi.org/10.1080/13813455.2019.1647250
Ahmad N, Banala VT, Kushwaha P, Karvand A, Sharma S, Tripathi AK et al (2016) Quercetin-loaded solid lipid nanoparticles improve osteoprotective activity in an ovariectomized rat model: a preventive strategy for post-menopausal osteoporosis. RSC Adv 6:97613–97628. https://doi.org/10.1039/C6RA17141A
Anand David AV, Arulmoli R, Parasuraman S (2016) Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn Rev 10:84–89. https://doi.org/10.4103/0973-7847.194044
Anuchapreeda S, Fukumori Y, Okonogi S, Ichikawa H (2012) Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy. J Nanotech 2012:270383. https://doi.org/10.1155/2012/270383
Arora R, Kuhad A, Kaur IP, Chopra K (2015) Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur J Pain 19:940–952. https://doi.org/10.1002/ejp.620
Baboota S, Shakeel F, Ahuja A, Ali J, Shafiq S (2007) Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharm 57:315–332. https://doi.org/10.2478/v10007-007-0025-5
Beard JR, Bloom DE (2015) Towards a comprehensive public health response to population ageing. Lancet 385:658–661. https://doi.org/10.1016/S0140-6736(14)61461-6
Berman AY, Motechin RA, Wiesenfeld MY, Holz MK (2017) The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precis Oncol 1:35. https://doi.org/10.1038/s41698-017-0038-6
Bhalekar MR, Madgulkar AR, Desale PS, Marium G (2017) Formulation of piperine solid lipid nanoparticles (SLN) for treatment of rheumatoid arthritis. Drug Dev Ind Pharm 43:1003–1010. https://doi.org/10.1080/03639045.2017.1291666
Bose S, Michniak Kohn B (2013) Preparation and characterization of lipid based nanosystems for topical delivery of quercetin. Eur J Pharm Sci 48:442–452. https://doi.org/10.1016/j.ejps.2012.12.005
Camins A, Junyent F, Verdaguer E, Beas-Zarate C, Rojas-Mayorquín AE, Ortuño-Sahagún D et al (2009) Resveratrol: an antiaging drug with potential therapeutic applications in treating diseases. Pharmaceuticals (Basel) 2:194–205. https://doi.org/10.3390/ph2030194
Carvalho FO, Silva ÉR, Nunes PS, Felipe FA, Ramos KPP, Ferreira LAS et al (2019) Effects of the solid lipid nanoparticle of carvacrol on rodents with lung injury from smoke inhalation. Naunyn Schmiedebergs Arch Pharmacol. https://doi.org/10.1007/s00210-019-01731-1
Chakraborty S, Shukla D, Mishra B, Singh S (2009) Lipid-an emerging platform for oral delivery of drugs with poor bioavailability. Eur J Pharm Biopharm 73:1–15. https://doi.org/10.1016/j.ejpb.2009.06.001
Chatterjee B, Hamed Almurisi S, Ahmed Mahdi Dukhan A, Mandal UK, Sengupta P (2016) Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug Deliv 23:3639–3652. https://doi.org/10.1080/10717544.2016.1214990
Chauhan AS (2015) Dendrimer nanotechnology for enhanced formulation and controlled delivery of resveratrol. Ann NY Acad Sci 1348:134–140. https://doi.org/10.1111/nyas.12816
Chen J, Dai WT, He ZM, Gao L, Huang X, Gong JM et al (2013) Fabrication and evaluation of curcumin-loaded nanoparticles based on solid lipid as a new type of colloidal drug delivery system. Indian J Pharm Sci 75:178–184. https://doi.org/10.4103/0250-474X.115463
Chikara S, Nagaprashantha LD, Singhal J, Horne D, Awasthi S, Singhal SS (2018) Oxidative stress and dietary phytochemicals: role in cancer chemoprevention and treatment. Cancer Lett 413:122–134. https://doi.org/10.1016/j.canlet.2017.11.002
Chintalapudi R, Murthy TE, Lakshmi KR, Manohar GG (2015) Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine. Int J Pharm Investig 5:205–213. https://doi.org/10.4103/2230-973X.167676
Chu C, Deng J, Man Y, Qu Y (2017) Green tea extracts epigallocatechin-3-gallate for different treatments. Biomed Res Int 2017:1–9. https://doi.org/10.1155/2017/5615647
Conte R, Marturano V, Peluso G, Calarco A, Cerruti P (2017) Recent advances in nanoparticle-mediated delivery of anti-inflammatory phytocompounds. Int J Mol Sci 18:709. https://doi.org/10.3390/ijms18040709
Corrêa RCG, Peralta RM, Haminiuk CWI, Maciel GM, Bracht A, Ferreira ICFR (2018) New phytochemicals as potential human anti-aging compounds: reality, promise, and challenges. Crit Rev Food Sci Nutr 58:942–957. https://doi.org/10.1080/10408398.2016.1233860
Costa D, Scognamiglio M, Fiorito C, Benincasa G, Napoli C (2019) Genetic background, epigenetic factors and dietary interventions which influence human longevity. Biogerontology 20:605–626. https://doi.org/10.1007/s10522-019-09824-3
Dai W, Ruan C, Zhang Y, Wang J, Han J, Shao Z et al (2019) Bioavailability enhancement of EGCG by structural modification and nano-delivery: a review. J Funct Foods. https://doi.org/10.1016/j.jff.2019.103732(Inpress)
Date AA, Desai N, Dixit R, Nagarsenker M (2010) Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine 5:1595–1616. https://doi.org/10.2217/nnm.10.126
Date AA, Hanes J, Ensign LM (2016) Nanoparticles for oral delivery: design, evaluation and state-of-the-art. J Control Release. 240:504–526. https://doi.org/10.1016/j.jconrel.2016.06.016
Dhawan S, Kapil R, Singh B (2011) Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery. J Pharm Pharmacol 63:342–351. https://doi.org/10.1111/j.2042-7158.2010.01225.x
Dokania S, Joshi AK (2015) Self-microemulsifying drug delivery system (SMEDDS)-challenges and road ahead. Drug Deliv 22:675–690. https://doi.org/10.3109/10717544.2014.896058
Dumont C, Bourgeois S, Fessi H, Jannin V (2018) Lipid-based nanosuspensions for oral delivery of peptides, acritical review. Int J Pharm 541:117–135. https://doi.org/10.1016/j.ijpharm.2018.02.038
Ezzati Nazhad Dolatabadi J, Valizadeh H, Hamishehkar H (2015) Solid lipid nanoparticles as efficient drug and gene delivery systems: recent breakthroughs. Adv Pharm Bull 5:151–159. https://doi.org/10.15171/apb.2015.022
Fangueiro JF, Andreani T, Fernandes L, Garcia ML, Egea MA, Silva AM et al (2014) Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation. Colloids Surf B Biointerfaces. 123:452–460. https://doi.org/10.1016/j.colsurfb.2014.09.042
Flora G, Gupta D, Tiwari A (2013) Nanocurcumin: a promising therapeutic advancement over native curcumin. Crit Rev Ther Drug Carrier Syst 30:331–368. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2013007236
Franco R, Navarro G, Martínez Pinilla E (2019) Hormetic and mitochondria-related mechanisms of antioxidant action of phytochemicals. Antioxidants (Basel) 8:373. https://doi.org/10.3390/antiox8090373
Frias I, Neves AR, Pinheiro M, Reis S (2016) Design, development, and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation. Drug Des Devel Ther 10:3519–3528. https://doi.org/10.2147/DDDT.S109589
Frozza RL, Bernardi A, Paese K, Hoppe JB, da Silva T, Battastini AM et al (2010) Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats. J Biomed Nanotechnol 6:694–703. https://doi.org/10.1166/jbn.2010.1161
Ganesan P, Arulselvan P, Choi DK (2017) Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus - current status. Int J Nanomed 12:1097–1111. https://doi.org/10.2147/ijn.s124601
Gao P, Rush BD, Pfund WP, Huang T, Bauer JM, Morozowich W et al (2003) Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J Pharm Sci 92:2386–2398. https://doi.org/10.1002/jps.10511
Garcês A, Amaral MH, Sousa Lobo JM, Silva AC (2018) Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: a review. Eur J Pharm Sci 112:159–167. https://doi.org/10.1016/j.ejps.2017.11.023
Goh PS, Ng MH, Choo YM, Amru NB, Chuah CH (2015) Production of nanoemulsions from palm-based tocotrienol rich fraction by microfluidization. Molecules 20:19936–19946. https://doi.org/10.3390/molecules201119666
Granja A, Frias I, Rute Neves A, Pinheiro M, Reis S (2017) Therapeutic potential of epigallocatechin gallate nanodelivery systems. Biomed Res Int 2017:5813793. https://doi.org/10.1155/2017/5813793
Granja A, Neves AR, Sousa CT, Pinheiro M, Reis S (2019) EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers. Heliyon 5:e02020. https://doi.org/10.1016/j.heliyon.2019.e02020
Hansen M, Kennedy BK (2016) Does longer lifespan mean longer healthspan? Trends Cell Biol 26:565–568. https://doi.org/10.1016/j.tcb.2016.05.002
Hsu CY, Wang PW, Alalaiwe A, Lin ZC, Fang JY (2019) Use of lipid nanocarriers to improve oral delivery of vitamins. Nutrients 11:68. https://doi.org/10.3390/nu11010068
Jampilek J, Kos J, Kralova K (2019) Potential of nanomaterial applications in dietary supplements and foods for special medical purposes. Nanomater (Basel) 9:296. https://doi.org/10.3390/nano9020296
Jazayeri Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi Maskooni M et al (2019) Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutr Metab (Lond) 16:8. https://doi.org/10.1186/s12986-019-0331-1
Jeevanandam J, Danquah MK, Debnath S, Meka VS, Chan YS (2015) Opportunities for nano-formulations in type 2 diabetes mellitus treatments. Curr Pharm Biotechnol 16:853–870. https://doi.org/10.2174/1389201016666150727120618
Joshi M, Patravale V (2006) Formulation and evaluation of nanostructured lipid carrier (NLC)–based gel of valdecoxib. Drug Dev Ind Pharm 32:911–918. https://doi.org/10.1080/03639040600814676
Joshi M, Patravale V (2008) Nanostructured lipid carrier (NLC) based gel of celecoxib. 346:124–132. https://doi.org/10.1016/j.ijpharm.2007.05.060
Joyce P, Whitby CP, Prestidge CA (2016) Nanostructuring biomaterials with specific activities towards digestive enzymes for controlled gastrointestinal absorption of lipophilic bioactive molecules. Adv Colloid Interface Sci 237:52–75. https://doi.org/10.1080/17425247.2019.1605353
Kadu PJ, Kushare SS, Thacker DD, Gattani SG (2011) Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS). Pharm Dev Technol 16:65–74. https://doi.org/10.3109/10837450903499333
Kakkar V, Kaur IP (2011) Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain. Food Chem Toxicol 49:2906–2913. https://doi.org/10.1016/j.fct.2011.08.006
Kakkar V, Muppu SK, Chopra K, Kaur IP (2013) Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats. Eur J Pharm Biopharm 85:339–345. https://doi.org/10.1016/j.ejpb.2013.02.005
Kamel AE, Fadel M, Louis D (2019) Curcumin-loaded nanostructured lipid carriers prepared using Peceol™ and olive oil in photodynamic therapy: development and application in breast cancer cell line. Int J Nanomed 14:5073–5085.https://doi.org/10.2147/IJN.S210484
Kawabata K, Mukai R, Ishisaka A (2015) Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. Food Funct 6:1399–1417. https://doi.org/10.1039/c4fo01178c
Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H et al (2014) Pharmaceutical particle technologies: an approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm Sci 9:304–316. https://doi.org/10.1016/j.ajps.2014.05.005
Khan N, Mukhtar H (2018) Tea polyphenols in promotion of human health. Nutrients 11:39. https://doi.org/10.3390/nu11010039
Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J (2012) Potentials and challenges in self-nanoemulsifying drug delivery systems. Expert Opin Drug Deliv 9:1305–1317. https://doi.org/10.1016/j.ajps.2018.10.003
Kim JT, Barua S, Kim H, Hong SC, Yoo SY, Jeon H et al (2017) Absorption study of genistein using solid lipid microparticles and nanoparticles: control of oral bioavailability by particle sizes. Biomol Ther (Seoul) 25:452–459. https://doi.org/10.4062/biomolther.2017.095
Knaub K, Sartorius T, Dharsono T, Wacker R, Wilhelm M, Schön C (2019) A novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb® formulation technology improving the oral bioavailability of cannabidiol in healthy subjects. Molecules 24:2967. https://doi.org/10.3390/molecules24162967
Kommuru TR, Gurley B, Khan MA, Reddy IK (2001) Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm 212:233–246. https://doi.org/10.1016/S0378-5173(00)00614-1
Krupkova O, Ferguson SJ, Wuertz Kozak K (2016) Stability of (-)-epigallocatechin gallate and its activity in liquid formulations and delivery systems. J Nutr Biochem 37:1–12. https://doi.org/10.1016/j.jnutbio.2016.01.002
Kumar DHL, Sarkar P (2018) Encapsulation of bioactive compounds using nanoemulsions. Environ Chem Lett 16:59–70. https://doi.org/10.1016/j.profoo.2011.09.246
Kumar M, Misra A, Mishra AK, Mishra P, Pathak K (2008a) Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting. J Drug Target 16:806–814. https://doi.org/10.1080/10611860802476504
Kumar M, Misra A, Babbar AK, Mishra AK, Mishra P, Pathak K (2008b) Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm 358:285–291. https://doi.org/10.1016/j.ijpharm.2008.03.029
Kumar A, Ahuja A, Ali J, Baboota S (2010) Conundrum and therapeutic potential of curcumin in drug delivery. Crit Rev Ther Drug Carrier Syst 27:279–312. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.v27.i4
Lai WF (2013) Nucleic acid delivery: roles in biogerontological interventions. Ageing Res Rev 12(1):310–315. https://doi.org/10.1016/j.arr.2012.08.003
Lai WF, Wong WT, Rogach AL (2020) Development of copper nanoclusters for in vitro and in vivo theranostic applications. Adv Mater 32(9):e1906872. https://doi.org/10.1002/adma.201906872
Li X, Nie SF, Kong J, Li N, Ju CY, Pan WS (2008) A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers. Int J Pharm 363:177–182. https://doi.org/10.1016/j.ijpharm.2008.07.017
Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S et al (2016) Quercetin, inflammation and immunity. Nutrients 8:167. https://doi.org/10.3390/nu8030167
Li J, Zhang CX, Liu YM, Chen KL, Chen G (2017) A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. Oncotarget 8:65717–65729. https://doi.org/10.18632/oncotarget.20084
Lin CH, Chen CH, Lin ZC, Fang JY (2017) Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. J Food Drug Anal 25:219–234. https://doi.org/10.1016/j.jfda.2017.02.001
Loureiro JA, Andrade S, Duarte A, Neves AR, Queiroz JF, Nunes C et al (2017) Resveratrol and grape extract-loaded solid lipid nanoparticles for the treatment of Alzheimer’s disease. Molecules 22:277. https://doi.org/10.3390/molecules22020277
Luo CF, Yuan M, Chen MS, Liu SM, Zhu L, Huang BY et al (2011) Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. Int J Pharm 410:138–144. https://doi.org/10.1016/j.ijpharm.2011.02.064
Lushchak O, Strilbytska OM, Yurkevych I, Vaiserman AM, Storey KB (2019) Implications of amino acid sensing and dietary protein to the aging process. Exp Gerontol 115:69–78. https://doi.org/10.1016/j.exger.2018.11.021
Managuli RS, Raut SY, Reddy MS, Mutalik S (2018) Targeting the intestinal lymphatic system: a versatile path for enhanced oral bioavailability of drugs. Expert Opin Drug Deliv 15:787–804. https://doi.org/10.1080/17425247.2018.1503249
Martínez Ballesta M, Gil Izquierdo Á, García Viguera C, Domínguez Perles R (2018) Nanoparticles and controlled delivery for bioactive compounds: outlining challenges for new “smart-foods” for health. Foods 7:72. https://doi.org/10.3390/foods7050072
McClements DJ (2011) Edible nanoemulsions: Fabrication, properties, and functional performance. Soft Matter 7:2297–2316. https://doi.org/10.1039/C0SM00549E
Mohseni R, ArabSadeghabadi Z, Ziamajidi N, Abbasalipourkabir R, RezaeiFarimani A (2019) Oral administration of resveratrol-loaded solid lipid nanoparticle improves insulin resistance through targeting expression of SNARE proteins in adipose and muscle tissue in rats with type 2 diabetes. Nanoscale Res Lett 14:227. https://doi.org/10.1186/s11671-019-3042-7
Muchow M, Maincent P, Muller RH (2008) Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. Drug Dev Ind Pharm 34:1394–1405. https://doi.org/10.1080/03639040802130061
Nayak AP, Mills T, Norton I (2016) Lipid based nanosystems for curcumin: past, present and future. Curr Pharm Des 22:4247–4256. https://doi.org/10.2174/138161282266616061408341
Negi LM, Tariq M, Talegaonkar S (2013) Nano scale self-emulsifying oil based carrier system for improved oral bioavailability of camptothecin derivative by P-glycoprotein modulation. Colloids Surf B Biointerfaces 111:346–353. https://doi.org/10.1016/j.colsurfb.2013.06.001
Patil P, Joshi P, Paradkar A (2004) Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of ketoprofen. AAPS PharmSciTech 5:42. https://doi.org/10.1208/pt050342
Patisaul HB (2017) Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours. Proc Nutr Soc 76:130–144. https://doi.org/10.1017/S0029665116000677
Piskovatska V, Strilbytska O, Koliada A, Vaiserman A, Lushchak O (2019a) Health benefits of anti-aging drugs. Subcell Biochem 91:339–392. https://doi.org/10.1007/978-981-13-3681-2_13
Piskovatska V, Stefanyshyn N, Storey KB, Vaiserman AM, Lushchak O (2019b) Metformin as a geroprotector: experimental and clinical evidence. Biogerontology 20:33–48. https://doi.org/10.1007/s10522-018-9773-5
Qiao Y, Wan J, Zhou L, Ma W, Yang Y, Luo W et al (2019) Stimuli-responsive nanotherapeutics for precision drug delivery and cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol 11:1527. https://doi.org/10.1002/wnan.1527
Radwan A, El Lakkany NM, William S, El Feky GS, Al Shorbagy MY, Saleh S et al (2019) A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection. Parasit Vectors 12:304. https://doi.org/10.1186/s13071-019-3563-z
Ramalingam P, Ko YT (2015) Enhanced oral delivery of curcumin from N-trimethyl chitosan surface-modified solid lipid nanoparticles: pharmacokinetic and brain distribution evaluations. Pharm Res 32:389–402. https://doi.org/10.1007/s11095-014-1469-1
Ramalingam P, Ko YT (2016) Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles. Colloids Surf B Biointerfaces 139:52–61. https://doi.org/10.1016/j.colsurfb.2015.11.050
Ramalingam P, Yoo SW, Ko YT (2016) Nanodelivery systems based on mucoadhesive polymer coated solid lipid nanoparticles to improve the oral intake of food curcumin. Food Res Int 84:113–119. https://doi.org/10.1016/j.foodres.2016.03.031
Rassu G, Porcu EP, Fancello S, Obinu A, Senes N, Galleri G et al (2018) Intranasal delivery of genistein-loaded nanoparticles as a potential preventive system against neurodegenerative disorders. Pharmaceutics 11:8. https://doi.org/10.3390/pharmaceutics11010008
Sadegh Malvajerd S, Azadi A, Izadi Z, Kurd M, Dara T, Dibaei M et al (2019) Brain delivery of curcumin using solid lipid nanoparticles and nanostructured lipid carriers: preparation, optimization, and pharmacokinetic evaluation. ACS Chem Neurosci 10:728–739. https://doi.org/10.1021/acschemneuro.8b00510
Saha S, Sadhukhan P, Sil PC (2014) Genistein: a phytoestrogen with multifaceted therapeutic properties. Mini Rev Med Chem 14:920–940. https://doi.org/0.2174/1389557514666141029233442
Salehi B, Stojanović Radić Z, Matejić J, Sharifi Rad M, Anil Kumar NV, Martins N et al (2019) The therapeutic potential of curcumin: a review of clinical trials. Eur J Med Chem 163:527–545. https://doi.org/10.1016/j.ejmech.2018.12.016
Salvia Trujillo L, Soliva Fortuny R, Rojas Graü MA, McClements DJ, Martín Belloso O (2017) Edible nanoemulsions as carriers of active ingredients: a review. Annu Rev Food Sci Technol 8:439–466. https://doi.org/10.1146/annurev-food-030216-025908
Santín Márquez R, Alarcón Aguilar A, López Diazguerrero NE, Chondrogianni N, Königsberg M (2019) Sulforaphane—role in aging and neurodegeneration. Geroscience. 41:655–670. https://doi.org/10.1007/s11357-019-00061-7
Santo IE, Pedro AS, Fialho R, Cabral Albuquerque E (2013) Characteristics of lipid micro- and nanoparticles based on supercritical formation for potential pharmaceutical application. Nanoscale Res Lett 8:386. https://doi.org/10.1186/1556-276X-8-386
Sarker MR, Franks SF (2018) Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies. Geroscience 40:73–95. https://doi.org/10.1007/s11357-018-0017-z
Shah SMA, Akram M, Riaz M, Munir N, Rasool G (2019) Cardioprotective potential of plant-derived molecules: a scientific and medicinal approach. Dose Response 27:1–14. https://doi.org/10.1177/1559325819852243
Shome S, Talukdar AD, Choudhury MD, Bhattacharya MK, Upadhyaya H (2016) Curcumin as potential therapeutic natural product: a nanobiotechnological perspective. J Pharm Pharmacol 68:1481–1500. https://doi.org/10.1111/jphp.12611
Silva Adaya D, Aguirre Cruz L, Guevara J, Ortiz Islas E (2017) Nanobiomaterials’ applications in neurodegenerative diseases. J Biomater Appl 31:953–984. https://doi.org/10.1177/0885328216659032
Singh KK, Vingkar SK (2008) Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine. Int J Pharm 347:136–143. https://doi.org/10.2147/IJN.S62630
Singh AP, Singh R, Verma SS, Rai V, Kaschula CH, Maiti P et al (2019) Health benefits of resveratrol: evidence from clinical studies. Med Res Rev. https://doi.org/10.1002/med.21565(Inpress)
Smith A, Giunta B, Bickford PC, Fountain M, Tan J, Shytle RD (2010) Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer’s disease. Int J Pharm 389:207–212. https://doi.org/10.1016/j.ijpharm.2010.01.012
Smoliga JM, Blanchard O (2014) Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution? Molecules 19:17154–17172. https://doi.org/0.3390/molecules191117154
Song WH, Yeom DW, Lee DH, Lee KM, Yoo HJ, Chae BR et al (2014) In situ intestinal permeability and in vivo oral bioavailability of celecoxib in supersaturating self-emulsifying drug delivery system. Arch Pharm Res 37:626–635. https://doi.org/10.1007/s12272-013-0202-7
Tagami T, Ozeki T (2017) Recent trends in clinical trials related to carrier-based drugs. J Pharm Sci 106:2219–2226. https://doi.org/10.1016/j.xphs.2017.02.026
Tan ME, He CH, Jiang W, Zeng C, Yu N, Huang W et al (2017) Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats. Int J Nanomedicine 12:3253–3265. https://doi.org/10.2147/IJN.S131893
Tiwari SB, Amiji MM (2006) Improved oral delivery of paclitaxel following administration in nanoemulsion formulations. J Nanosci Nanotechnol 6:3215–3221. https://doi.org/10.1166/jnn.2006.440
Tiwari R, Pathak K (2011) Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake. Int J Pharm 415:232–243. https://doi.org/10.1016/j.ijpharm.2011.05.044
Trinovita E, Rachmawati M, Sutriyo S, Mun’im A (2019) In vitro penetration activity of ionic liquid-Gnetum gnemon seed extract loaded solid lipid nanoparticles. J Appl Pharm Sci 9:9–16. https://doi.org/10.7324/japs.2019.91002
Vaiserman A, Lushchak O (2019) Developmental origins of type 2 diabetes: focus on epigenetics. Ageing Res Rev 55:100957. https://doi.org/10.1016/j.arr.2019.100957
Vaiserman AM, Lushchak O, Koliada AK (2016) Anti-aging pharmacology: promises and pitfalls. Ageing Res Rev 31:9–35. https://doi.org/10.1016/j.arr.2016.08.004
Vaiserman AM, Koliada AK, Marotta F (2017) Gut microbiota: a player in aging and a target for anti-aging intervention. Ageing Res Rev 35:36–45. https://doi.org/10.1016/j.arr.2017.01.001
Vijaya R, Ram Kishan KR (2018) Development and in vitro characterization of solid lipid nanoparticles (SLN) containing methotrexate and doxycycline. Inter J Drug Deliv Technol 8:137–143. https://doi.org/10.25258/ijddt.8.3.4
Vijayakumar A, Baskaran R, Jang YS, Oh SH, Yoo BK (2017) Quercetin-loaded solid lipid nanoparticle dispersion with improved physicochemical properties and cellular uptake. AAPS PharmSciTech 18:875–883. https://doi.org/10.1208/s12249-016-0573-4
Vyas TK, Shahiwala A, Amiji MM (2008) Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations. Int J Pharm 347:93–101. https://doi.org/10.1016/j.ijpharm.2007.06.016
Wei Y, Ye X, Shang X, Peng X, Bao Q, Liu M, Guo M, Li F (2012) Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS). Colloids Surf A Physic Engine Asp 396:22–28. https://doi.org/10.1016/j.colsurfa.2011.12.025
Weiss J, Decker EA, McClements DJ, Kristbergsson K, Helgason T, Awad T (2008) Solid lipid nanoparticles as delivery systems for bioactive food components. Food Biophys 3:146–154. https://doi.org/10.1007/s11483-008-9065-8
World Health Organization (2012) World health statistics. Retrieved on 13 June 2012 from https://www.who.int/gho/publications/world_health_statistics/2012/en/
Zhang Y, Yu J, Qiang L, Gu Z (2018) Nanomedicine for obesity treatment. Sci China Life Sci 61:373–379. https://doi.org/10.2174/1389201016666150727120618
Zhang L, Zhu K, Zeng H, Zhang J, Pu Y, Wang Z et al (2019) Resveratrol solid lipid nanoparticles to trigger credible inhibition of doxorubicin cardiotoxicity. Int J Nanomed 14:6061–6071. https://doi.org/10.2147/IJN.S211130
Zhu F, Du B, Xu B (2018) Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: a review. Crit Rev Food Sci Nutr 58:1260–1270. https://doi.org/10.1080/10408398.2016.1251390
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Glossary
- Bioavailability
-
The fraction of absorbed drug or active compound reaching the systemic circulation.
- Calorie restriction
-
A reduction in calorie intake without malnutrition.
- Epimerization
-
A chemical process in which an epimer is converted to its chiral counterpart.
- Freeze drying
-
A method of removing water from a frozen material via sublimation of ice crystals.
- Gastric residence time
-
The length of time during which a material is kept in the stomach.
- Healthspan
-
The period of life spent in good health, free from the chronic diseases and disabilities of aging.
- Lipids
-
Organic molecules with hydrophobic or amphiphilic properties able to form structures such as vesicles, liposomes, or membranes in an aqueous environment.
- Microfluidization
-
A homogenization technique in which high pressure is applied to a fluid and is used to force the fluid to pass through microchannels. It is used extensively for generation of emulsions and nanoemulsions.
- Nanocarriers
-
Materials with particle size up to 100 nanometrers used to increase bioavailability of drugs with low solubility and absorption.
- Nano-delivery
-
Delivery of drugs or substances with nanocarriers.
- Phytobioactive compounds
-
Compounds of natural origin, being able to affect varied processes in biological systems.
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Lushchak, O., Karpenko, R., Zayahckivska, A., Koliada, A., Vaiserman, A. (2020). Lipid-Based Nano-delivery of Phytobioactive Compounds in Anti-aging Medicine. In: Lai, WF. (eds) Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Healthy Ageing and Longevity, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-54490-4_8
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