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Pediatric Nephrology pp 1033–1046Cite as

Inherited Disorders of Renal Magnesium Handling

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Abstract

Magnesium (Mg2+) depletion usually occurs secondary to another disease process or to a therapeutic agent. During infancy and childhood, a substantial proportion of patients receiving medical attention for signs of hypomagnesemia is affected by inherited renal disorders associated with Mg2+ wasting. In these disorders, hypomagnesemia either may be a leading symptom or may be part of a complex phenotype resulting from tubular dysfunction, as detailed below. Advances in molecular genetics of hereditary hypomagnesemia substantiated the role of a variety of genes and their encoded proteins in human epithelial Mg2+ transport, and helped to characterize different clinical subtypes of hereditary Mg2+-wasting. A careful clinical and biochemical assessment allows to distinguish the different disease entities in most cases, even when there is a considerable overlap in the phenotypic characteristics.

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Authors and Affiliations

  1. Department of General Pediatrics, Pediatric Nephrology, University Hospital Münster, Münster, Germany

    Martin Konrad & Karl Peter Schlingmann

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  1. Martin Konrad
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  2. Karl Peter Schlingmann
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Correspondence to Martin Konrad .

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Editors and Affiliations

  1. Division of Nephrology, Department of Pediatric Specialties, Bambino Gesù Children’s Hospital – IRCCS, Rome, Italy

    Francesco Emma

  2. Division of Nephrology and Hypertension, The Heart Institute, Cincinnati Children’s Hospital Medical Center, College of Medicine, Cincinnati, OH, USA

    Stuart L. Goldstein

  3. Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India

    Arvind Bagga

  4. Division of Pediatric Nephrology, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Carlton M. Bates

  5. Department of Paediatric Nephrology, Great Ormond Street Hospital for Children, NHS Foundation Trust and University College London Institute of Child Health, London, UK

    Rukshana Shroff

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Konrad, M., Schlingmann, K.P. (2022). Inherited Disorders of Renal Magnesium Handling. In: Emma, F., Goldstein, S.L., Bagga, A., Bates, C.M., Shroff, R. (eds) Pediatric Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-030-52719-8_109

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  • DOI: https://doi.org/10.1007/978-3-030-52719-8_109

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