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The ADME Encyclopedia pp 1–13Cite as

Pharmaceutical Nanocarriers: Absorption

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Synonyms

Absoption; Bioavailability; Uptake

Definition

In this entry, pharmaceutical nanocarriers (PN), nanocarriers, and nanoparticles refer to polymeric nanoparticles (nanocapsules, lipid-core nanocapsules, and nanospheres) and lipid-based nanocarriers (solid lipid nanoparticles, nanostructured lipid nanoparticles, liposomes, and nanoemulsions).

The goal of this entry is to discuss (i) the absorption process and pharmacokinetic parameters related to the absorption; (ii) anatomical and physiological barriers to drug delivery systems absorption; and (iii) absorption mechanisms of free and nanoencapsulated drugs following oral, nasal, pulmonary, dermal, vaginal, and ophthalmic delivery.

Absorption

Absorption is the pharmacokinetics process of the drug entering the bloodstream from the site of administration. Absorption is only present in extravascular routes of administration.

The process of absorption consists of several sequential phases. The first phase is the administration of the...

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References

  1. Singh AK. Nanoparticle pharmacokinetics and toxicokinetics. In: Singh AK, editor. Engineered nanoparticles structure, properties and mechanisms of toxicity, vol. 01. Academic; 2016. p. 229–93. https://doi.org/10.1016/B978-0-12-801406-6.00006-6.

    Chapter  Google Scholar 

  2. Lu Y, Qi J, Wu W. Lipid nanoparticles: In vitro and in vivo approaches in drug delivery and targeting. In: Grumezescu AM, editor. Drug targeting and stimuli sensitive drug delivery systems, vol. 02. 1st ed. William Andrew; 2018. p. 749–83. https://doi.org/10.1016/B978-0-12-813689-8.00020-3.

    Chapter  Google Scholar 

  3. Chenthamara D, Subramaniam S, Ramakrishnan SG, Krishnaswamy S, Essa MM, Lin FH, et al. Therapeutic efficacy of nanoparticles and routes of administration. Biomater Res. 2019;23:20. https://doi.org/10.1186/s40824-019-0166-x. 166 [pii].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ensign LM, Tang BC, Wang YY, Tse TA, Hoen T, Cone R, et al. Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus. Sci Transl Med. 2012;4(138):138ra79. https://doi.org/10.1126/scitranslmed.3003453. 4/138/138ra79 [pii].

    Article  PubMed  Google Scholar 

  5. Mansuri S, Kesharwani P, Tekade RK, Jain NK. Lyophilized mucoadhesive-dendrimer enclosed matrix tablet for extended oral delivery of albendazole. Eur J Pharm Biopharm. 2016;102:202–13. https://doi.org/10.1016/j.ejpb.2015.10.015. S0939-6411(15)00430-0 [pii].

    Article  CAS  PubMed  Google Scholar 

  6. Wang Y, Pi C, Feng X, Hou Y, Zhao L, Wei Y. The influence of nanoparticle properties on oral bioavailability of drugs. Int J Nanomedicine. 2020;15:6295–310. https://doi.org/10.2147/IJN.S257269. 257269 [pii].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ramadan A, Lagarce F, Tessier-Marteau A, Thomas O, Legras P, Macchi L, et al. Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study. Int J Nanomedicine. 2011;6:2941–51. https://doi.org/10.2147/IJN.S25791. ijn-6-2941 [pii].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Padhye T, Maravajjala KS, Swetha L, Sharma S, Roy A. A comprehensive review of the strategies to improve oral drug absorption with special emphasis on the cellular and molecular mechanisms. J Drug Deliv Sci Technol. 2020;102178. https://doi.org/10.1016/j.jddst.2020.102178. S1773-2247(20)31467-2.

  9. Mansi K, Shah PK, Vora N, Patel NK, Jain S, Lin S. Lipid nanocarriers: preparation, characterization and absorption mechanism and applications to improve oral bioavailability of poorly water-soluble drugs. In: Grumezescu AM, editor. Biomedical applications of nanoparticles, vol. 01. William Andrew; 2019. https://doi.org/10.1016/B978-0-12-816506-5.00003-6.

    Chapter  Google Scholar 

  10. Kovacevic AB. Lipid nanocarriers for delivery of poorly soluble and poorly permeable drugs. In: Shegokar R, editor. Nanopharmaceuticals. volume 1: Expectations and realities of multifunctional drug delivery systems. 1st ed. Elsevier; 2020. p. 151–73. https://doi.org/10.1016/B978-0-12-817778-5.00008-7.

    Chapter  Google Scholar 

  11. Fang G, Tang B. Advanced delivery strategies facilitating oral absorption of heparins. Asian J Pharm Sci. 2020;15(4):449–60. https://doi.org/10.1016/j.ajps.2019.11.006. S1818-0876(19)30743-3 [pii].

    Article  PubMed  PubMed Central  Google Scholar 

  12. Ali Khan A, Mudassir J, Mohtar N, Darwis Y. Advanced drug delivery to the lymphatic system: lipid-based nanoformulations. Int J Nanomedicine. 2013;8:2733–44. https://doi.org/10.2147/IJN.S41521. ijn-8-2733 [pii].

    Article  CAS  PubMed  Google Scholar 

  13. Salah E, Abouelfetouh MM, Pan Y, Chen D, Xie S. Solid lipid nanoparticles for enhanced oral absorption: a review. Colloids Surf B Biointerfaces. 2020;196:111305. https://doi.org/10.1016/j.colsurfb.2020.111305. S0927-7765(20)30661-5 [pii].

    Article  CAS  PubMed  Google Scholar 

  14. Cho HJ, Park JW, Yoon IS, Kim DD. Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Int J Nanomedicine. 2014;9:495–504. https://doi.org/10.2147/IJN.S56648. ijn-9-495 [pii].

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bourganis V, Kammona O, Alexopoulos A, Kiparissides C. Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics. Eur J Pharm Biopharm. 2018;128:337–62. https://doi.org/10.1016/j.ejpb.2018.05.009. S0939-6411(18)30214-5 [pii].

    Article  CAS  PubMed  Google Scholar 

  16. Bruinsmann FA, Richter Vaz G, de Cristo Soares Alves A, Aguirre T, Raffin Pohlmann A, Staniscuaski Guterres S, et al. Nasal drug delivery of anticancer drugs for the treatment of glioblastoma: preclinical and clinical trials. Molecules. 2019;24(23):E4312. https://doi.org/10.3390/molecules24234312.

    Article  CAS  PubMed  Google Scholar 

  17. Lu X, Zhu T, Chen C, Liu Y. Right or left: the role of nanoparticles in pulmonary diseases. Int J Mol Sci. 2014;15(10):17577–600. https://doi.org/10.3390/ijms151017577.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Paranjpe M, Muller-Goymann CC. Nanoparticle-mediated pulmonary drug delivery: a review. Int J Mol Sci. 2014;15(4):5852–73. https://doi.org/10.3390/ijms15045852.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Iyer R, Hsia CC, Nguyen KT. Nano-therapeutics for the lung: state-of-the-art and future perspectives. Curr Pharm Des. 2015;21(36):5233–44. https://doi.org/10.2174/1381612821666150923095742. CPD-EPUB-70587 [pii].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Shahiwala A, Misra A. Pulmonary absorption of liposomal levonorgestrel. AAPS PharmSciTech. 2004;5(1):E13. https://doi.org/10.1208/pt050113.

    Article  PubMed  Google Scholar 

  21. Guterres SS, Alves MP, Pohlmann AR. Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights. 2007;2:147–57.

    Article  Google Scholar 

  22. Rai VK, Mishra N, Yadav KS, Yadav NP. Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: formulation development, stability issues, basic considerations and applications. J Control Release. 2018;270:203–25. https://doi.org/10.1016/j.jconrel.2017.11.049. S0168-3659(17)31056-8 [pii].

    Article  CAS  PubMed  Google Scholar 

  23. Thotakura N, Kumar P, Wadhwa S, Raza K, Katare P. Dermatokinetics as an important tool to assess the bioavailability of drugs by topical nanocarriers. Curr Drug Metab. 2017;18(5):404–11. https://doi.org/10.2174/1389200218666170306104042. CDM-EPUB-82129 [pii].

    Article  CAS  PubMed  Google Scholar 

  24. Desai PR, Shah PP, Patlolla RR, Singh M. Dermal microdialysis technique to evaluate the trafficking of surface-modified lipid nanoparticles upon topical application. Pharm Res. 2012;29(9):2587–600. https://doi.org/10.1007/s11095-012-0789-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Mazen M, El-Hammadia JLA. Nanotechnology for vaginal drug delivery and targeting. In: Mozafari M, editor. Nanoengineered biomaterials for advanced drug delivery, vol. 01. 1st ed. Elsevier; 2020. p. 647–82. https://doi.org/10.1016/B978-0-08-102985-5.00026-7.

    Chapter  Google Scholar 

  26. Frank LA, Sandri G, D’Autilia F, Contri RV, Bonferoni MC, Caramella C, et al. Chitosan gel containing polymeric nanocapsules: a new formulation for vaginal drug delivery. Int J Nanomedicine. 2014;9:3151–61. https://doi.org/10.2147/IJN.S62599. ijn-9-3151 [pii].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Cardillo JA, Herrero-Vanrell R. Ocular pharmacokinetic, drug bioavailability, and intraocular drug delivery systems. In: Nguyen Q, Rodrigues E, Farah M, Mieler WF, editors. Retinal pharmacotherapy, vol. 01. Saunders; 2010. p. 408. https://doi.org/10.1016/B978-1-4377-0603-1.00014-4.

    Chapter  Google Scholar 

  28. Battaglia L, Serpe L, Foglietta F, Muntoni E, Gallarate M, Del Pozo RA, et al. Application of lipid nanoparticles to ocular drug delivery. Expert Opin Drug Deliv. 2016;13(12):1743–57. https://doi.org/10.1080/17425247.2016.1201059.

    Article  CAS  PubMed  Google Scholar 

  29. Castro BFM, de Oliveira Fulgêncio G, Domingos LC, Cotta OAL, Silva-Cunha A, Fialho SL. Positively charged polymeric nanoparticles improve ocular penetration of tacrolimus after topical administration. J Drug Deliv Sci Technol. 2020;60:101912. https://doi.org/10.1016/j.jddst.2020.101912.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Pampa, Uruguaiana, Brazil

    Sandra Elisa Haas

  2. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Fernando Carreño

  3. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Teresa Dalla Costa

Authors
  1. Sandra Elisa Haas
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  2. Fernando Carreño
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  3. Teresa Dalla Costa
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Corresponding author

Correspondence to Sandra Elisa Haas .

Section Editor information

  1. Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of la Plata (UNLP) - Argentinean National Council of Scientific and Technical Research (CONICET), La Plata, Buenos Aires, Argentina

    Alan Talevi

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Haas, S.E., Carreño, F., Dalla Costa, T. (2021). Pharmaceutical Nanocarriers: Absorption. In: The ADME Encyclopedia. Springer, Cham. https://doi.org/10.1007/978-3-030-51519-5_111-1

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  • DOI: https://doi.org/10.1007/978-3-030-51519-5_111-1

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  • Print ISBN: 978-3-030-51519-5

  • Online ISBN: 978-3-030-51519-5

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