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Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier

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Oxygen Transport to Tissue XLII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1269))

Abstract

The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explain the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here, we show that the BBB opens for high-molecular-weight compounds after exposure to loud sound (100 dB 370 Hz) in rats. The role of stress induced by loud sound and the systemic and molecular mechanisms behind it are discussed in the framework of the BBB. This opens an informative platform for novel fundamental knowledge about the nature of BBB and for the development of a noninvasive brain drug delivery technology.

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Acknowledgments

This work was supported by grants from the Russian Science Foundation (20-15-00090): Visualization of the meningeal lymphatics; RFBR 20-015-00308a: SpO2 recording; grant from the RF Governmental grant 075-15-2019-1885: Methods for the BBB opening. DB was supported by NIH R01 NS112808.

Author information

Authors and Affiliations

  1. Saratov State University, Saratov, Russia

    O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Esmat, A. Khorovodov, A. Terskov, M. Klimova, I. Agranovich, I. Blokhina & V. Tuchin

  2. Lovelace Biomedical Research Institute, Albuquerque, NM, USA

    D. Bragin

  3. University of New Mexico School of Medicine, Departments of Neurology andNeurosurgery, Albuquerque, NM, USA

    D. Bragin

  4. Lovelace Biomedical Research Institute, Albuquerque, NM, USA

    O. Bragina

  5. University of New Mexico, College of Pharmacy, Albuquerque, NM, USA

    Y. Yang

  6. Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, Russia

    A. Shirokov

  7. Saratov State Medical University, Saratov, Russia

    N. Navolokin

  8. Saratov State University, Saratov, Russia

    J. Kurths

  9. Humboldt University, Physics Department, Berlin, Germany

    J. Kurths

  10. Potsdam Institute for Climate Impact Research, Potsdam, Germany

    J. Kurths

Authors
  1. O. Semyachkina-Glushkovskaya
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  2. D. Bragin
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  3. O. Bragina
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  4. Y. Yang
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  5. A. Abdurashitov
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  6. A. Esmat
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  7. A. Khorovodov
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  8. A. Terskov
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  9. M. Klimova
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  10. I. Agranovich
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  11. I. Blokhina
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  12. A. Shirokov
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  13. N. Navolokin
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  14. V. Tuchin
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  15. J. Kurths
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of New Mexico, Albuquerque, NM, USA

    Edwin M. Nemoto

  2. Bozen, Italy

    Eileen M. Harrison

  3. Department of Chemistry, New Mexico Institute of Mining and Technology (New Mexico Tech), Socorro, NM, USA

    Sally C. Pias

  4. Lovelace Biomedical Research Institute, Albuquerque, NM, USA

    Denis E. Bragin

  5. St. Lorenzen, Italy

    David K. Harrison

  6. Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Joseph C. LaManna

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Semyachkina-Glushkovskaya, O. et al. (2021). Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier. In: Nemoto, E.M., Harrison, E.M., Pias, S.C., Bragin, D.E., Harrison, D.K., LaManna, J.C. (eds) Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol 1269. Springer, Cham. https://doi.org/10.1007/978-3-030-48238-1_31

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