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Treatment of Isolated Liver Metastasis from Non-colorectal Cancer

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Book cover Hepato-Pancreato-Biliary Malignancies

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Abstract

Liver metastases from a wide variety of malignancies are a major source of cancer-related morbidity and mortality, and because they are so common, they contribute to a substantial portion of the modern hepatobiliary surgeon’s practice. Traditionally, metastatic liver lesions have portended a poor long-term prognosis. However, with advances in multimodal treatment of colorectal cancer, the most common primary site for metastatic liver lesions, as well as advances in the operative and perioperative care of patients undergoing liver resection, there have been dramatic improvements in long-term outcomes for patients with colorectal liver metastases.

More recently, a similar approach has been used in non-colorectal liver metastases with apparent long-term survival benefits. The wide variety of primary tumor sites has complicated the study of these lesions, and their management therefore remains unclear. However, numerous studies over the last decade evaluating grouped cohorts of miscellaneous non-colorectal liver metastases, and several focused studies evaluating metastases from single primary sites, have shown a benefit to liver-directed therapy in the setting of isolated liver metastases from non-colorectal primaries. This chapter will review the current literature on this topic.

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  1. Atrium Health, Charlotte, NC, USA

    John B. Martinie, Benjamin M. Motz & Jordan N. Robinson

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  1. John B. Martinie
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  2. Benjamin M. Motz
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  3. Jordan N. Robinson
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Correspondence to John B. Martinie .

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Editors and Affiliations

  1. Medical Director, Capital Health Cancer Center, Director, CH Pancreas Center of Excellence, Director, CH Liver Center of Excellence, Pennington, NJ, USA

    Cataldo Doria

  2. Director of Interventional Gastroenterology, Capital Health Medical Center, Pennington, NJ, USA

    Jason N. Rogart

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Martinie, J.B., Motz, B.M., Robinson, J.N. (2022). Treatment of Isolated Liver Metastasis from Non-colorectal Cancer. In: Doria, C., Rogart, J.N. (eds) Hepato-Pancreato-Biliary Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-41683-6_9

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