Abstract
Phytomedicines have been widely implemented throughout the world for centuries and recognized by scientific committees and patients for their better therapeutic value, with fewer adverse effects offered by herbal medicines compared with modern drugs. The enhancement of phytotherapeutics demands a scientific approach in delivering the biological constituent efficiently, in a sustained manner to achieve patient satisfaction and avoid repeated administration. Incorporation of phytomedicines into nanotechnology is an innovative approach to magnifying the solubility, absorption rate, and permeation membrane of phytomedicine, which possess the high bioavailability and therapeutic potential of these medicinal plants. Therefore, this chapter reviews numerous investigations regarding the pharmacological activity of phytomedicine, the main factors that limit the therapeutic potential of phytomedicine, and the incorporation of phytomedicine into several nanocarriers. Hence, the overall discussion has revealed the potential of novel drug delivery systems in intensifying the bioavailability and efficacy of the pharmacological activity of phytomedicine. This finding depicts the several in vivo assays of phytomedicine-loaded nanocarriers that have been discussed throughout this chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aziz ZAA, Ali SAM, Ahmad A, Mohd-Setapar SH (2016) Application of herbal extract and its medicinal value. Pharm Lett 8(9):161–167
Bhagat SS, Ghone RA, Suryakar AN, Hundekar PS (2011) Lipid peroxidation and antioxidant vitamin status in colorectal cancer patients Indian j physiol pharmacol 55(1):72–76
Bilia AR, Guccione C, Isacchi B, Righeschi C, Firenzuoli F, Bergonzi MC (2014) Essential oils loaded in nanosystems: a developing strategy for a successful therapeutic approach. Evid Based Complement Alternat Med 2014:1–14
Bonifácio BV, da Silva PB, dos Santos Ramos MA, Negri KMS, Bauab TM, Chorill M (2014) Nanotechnology-based drug delivery systems and medicines: a review. Int J Nanomedicine 9(1):1–5
Burits M, Bucar F (2000) Antioxidant activity of Nigella sativa essential oil Phytotherapy research, 14(5):323–328
Chew AL, Jessica JJA, Sasidharan S (2012) Antioxidant and antibacterial activity of different parts of Leucas aspera. Asian Pac J Trop Biomed 2(3):176–180
Cowan M (1999) Plant products as antimicrobial agents. Clin Microbiol Rev 12:564–582
Debnath A, Kumar A (2015) Structural and functional significance of niosome and proniosome in drug delivery system. Int J Pharm Eng 3(3):621–637
Efferth T, Konkimall VB, Wang YF, Sauerbrey A, Meinhardt S, Zintl F (2008) Prediction of broad spectrum resistance of tumors towards anticancer drugs. Clin Cancer Res 14:2405–2412
Egert S, Rimbach G (2011) Which sources of flavonoids: complex diets or dietary supplements? Adv Nutr 2:8–14
Faried A, Kurnia D, Faried LS, Usman N, Miyazaki T, Kato H, Kuwano H (2007) Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macroscarpa (Scheff) Boerl, on human cancer cell lines. Int J Oncol 30(3):605–613
Fazly Bazzaz BS, Khameneh B, Namazi N, Iranshahi M, Davoodi D, Golmohammadzadeh S (2018) Solid lipid nanoparticles carrying Eugenia caryophyllata essential oil: the novel nanoparticulate systems with broad‐spectrum antimicrobial activity. Letters in Applied Microbiology 66(6):506–513
Ghasemzadeh A, Jaafar HZ (2013) Profiling of phenolic compounds and their antioxidant and anticancer activities in pandan (Pandanus amaryllifolius Roxb) extracts from different locations of Malaysia. BMC Complement Altern Med 13(1):341–350
Gunasekaran T, Haile T, Nigusse T, Dhanaruju MD (2014) Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian J Trop Biomed 1:S1–S7
Gupta LM, Raina R (1998) Side effects of some medicinal plants. Curr Sci 75(9):897–900
Hosseini SF, Zandi M, Rezaei M, Farahmandghavi F (2013) Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study. Carbohydrate polymers 95(1):50–56
Joseph M, Trinh HM, Mitra AK (2017) Peptide and protein-based therapeutic agents. In: Mitra A, Cholkar K, Mandal A (eds) Emerging nanotechnologies for diagnostics, drug delivery and medical devices, 1st edn. Elsevier, Amsterdam, pp 145–167
Kamboj VP (2000) Herbal medicine. Curr Sci 78(1):35–39
Kazi KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K (2010) Niosome: a future of targeted drug delivery systems. J Adv Pharm Technol Res 1(4):374–380
Kiaee G, Javar HA, Kiaee B (2016) Preparation and characterization of liposome containing Minoxidil and Rosemary essential oil. J In Silico In Vitro Pharmacol 2:3
Kingston DGI (2011) Modern natural products drug discovery and its relevance to biodiversity conservation. J Nat Prod 74:496–511
Krishnaiah D, Sarbatly R, Nithyanandam R (2011) A review of the antioxidant potential of medicinal plant species. Food Bioprod Process 89(3):217–233
Lai F, Wissing SA, Müller RH, Fadda AM (2006) Artemisia arborescens L. essential oil-loaded solid lipid nanoparticles for potential agricultural application: preparation and characterization. J Am Assoc Pharm Sci 7(1):E10–E19
Lee RW, Shenoy DB, Sheel R (2010) Micellar nanoparticles: applications for topical and passive transdermal drug delivery. In: Kulkarni VS (ed) Handbook of non-invasive drug delivery systems, 1st edn. Elsevier, Burlington, MA, pp 37–58
Leelarungrayub J, Manorsoi J, Manorsoi A (2017) Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model. Int J Nanomedicine 12(1):2469–2476
Maregesi SM, Pieters L, Ngassapa OD, Apers S, Vingerhoets R, Cos P, Berghe DAV, Vlietinck AJ (2008) Screening of some Tanzanian medicinal plants from Bunda district for antibacterial, antifungal and antiviral activities. J Ethnopharmacol 1119(1):58–66
Moghimipour E, Aghel N, Mahmoudabadi AZ, Ramezani Z, Handali S (2012) Preparation and characterization of liposomes containing essential oil of Eucalyptus camaldulensis leaf. Jundishapur J Nat Pharm Prod 7(3):117–122
Mohamed IET, Nur E, Abdelrahman MEN (2010) The antibacterial, antiviral activities and phytochemical screening of some Sudanese medicinal plants. EurAsian J BioSci 4:8–16
Mostafa DM, Abd El-Alim SH, Asfour MH, Al-Okbi SY, Mohamed DA, Awad G (2015) Transdermal nanoemulsion of Foeniculum vulgare Mill. essential oil: preparation, characterization and evaluation of antidiabetic potential. J Drug Deliv Sci Technol 29(1):99–106
Mudur G (1995) Mandatory rural practice proposed in India. Br Med J 311(7014):1186
Natrajan D, Srinivasan S, Sundar K, Ravindran A (2015) Formulation of essential oil-loaded chitosan–alginate nanocapsules Journal of food and drug analysis 23(3):560–568
Ngamkitidechakul C, Jaijoy K, Hansakul P, Soonthornchareonnon N, Sireeratawong S (2010) Antitumour effects of Phyllanthus emblica L. induction of cancer cell apoptosis and inhibition of in vivo tumour promotion and in vitro invasion human cancer cells. Phytother Res 24(9):1405–1413
Pal SK, Shukla Y (2003) Herbal medicine: current status and the future. Asian Pac J Cancer Prev 4(4):281–288
Plengsuriyakam T, Viyanant V, Eursitthichai V, Tesana S, Chaijaroenkul W, Itharat A, Na-Bangchang K (2012) Cytotoxicity, toxicity, and anticancer activity of Zingiber officinale Roscoe against cholangiocarcinoma. Asian Pacific Journal of Cancer Prevention, 13(9):4597–4606
Priprem A, Janpim K, Nualkaew S, Mahakunakorn P (2016) Topical niosome gel of Zingiber cassumunar Roxb. extract for anti-inflammatory activity enhanced skin permeation and stability of compound D. AAPS PharmSciTech1 7(3):631–639
Qureshi NA, Al-Bedah AM (2013) Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatr Dis Treat 9:639–658
Rai VK, Mishra N, Yadav KS, Yadav NP (2018) Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: formulation development, stability issues, basic considerations and applications. J Control Release 270:203–225
Rinaldi F, Hanieh PN, Longhi C, Carradori S, Secci D, Zengin G, Ammendolia MG, Mattia E, Del Favero E, Marianecci C, Carafa M (2017) Neem oil nanoemulsions: characterisation and antioxidant activity. Journal of Enzyme Inhibition and Medicinal Chemistry 32(1):1265–1273
Sebaaly C, Jraij A, Fessi H, Charcosset C, Greige-Gerges H (2015) Preparation and characterization of clove essential oil-loaded liposomes. Food Chemistry 178:52–62
Sen A, Batra A (2012) Evaluation of antimicrobial activity of different solvent extracts of medicinal plant: Melia azedarach L. Int J Curr Pharm Res 4(2):67–73
Sen S, Chakraborty R, Sridhar C, Reddy YSR, De B (2010) Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. Int J Pharm Sci Rev Res 3(1):91–100
Sen S, De B, Devanna N, Chakraborty R (2013) Total phenolic, total flavonoid content and antioxidant capacity of the leaves of Meyna spinosa Roxb., an Indian medicinal plant. Chin J Nat Med 11(2):149–157
Shin HC, Hwang HJ, Kang KJ, Lee BH (2006) An antioxidative and anti-inflammatory agent for potential treatment of osteoarthritis from Ecklonia cava. Arch Pharm Res 29(2):165–172
Shirwaikar A, Patel B, Kamariya Y, Parmar V, Khan S (2011) In vitro free radical scavenging studies of Sphaeranthus indicus (Linn). Indian J Exp Biol 44(12):993–996
Shoemaker M, Hamilton B, Dairkee SH, Cohen I, Campbell MJ (2005) In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res 19(7):649–651
Siriwatabametanon N, Fiebich BL, Efferth T, Prieto JM, Heinrich M (2010) Traditionally used Thai medicinal plants in vitro anti-inflammatory, anticancer and antioxidant activities. J Ethnopharmacol 130(2):196–207
Srinivasan D, Sangeetha N, Suresh T, Perumalsamy PL (2001) Antimicrobial activity of certain Indian medicinal plant used in folkloric medicine. J Ethnopharmacol 74:217–220
Su YL, Fu ZY, Zhang JY, Wang WM, Wang H, Wang YC (2008) Microencapsulation of Radix salvia miltiorrhiza nanoparticles by spray-drying. Powder Technol 184:114–121
Sugumar S, Mukherjee A, Chandrasekaran N (2015) Eucalyptus oil nanoemulsion-impregnated chitosan film: antibacterial effects against a clinical pathogen, Staphylococcus aureus, in vitro International Journal of Nanomedicine 10(1):67
Vickers A, Zollman C (1999) ABC of complementary medicine: herbal medicine. Br Med J 319(7216):1050–1053
Vilasau J, Solans C, Gómez MJ, Dabrio J, Mújika-Garai R, Esquena J (2011) Phase behaviour of a mixed ionic/nonionic surfactant system used to prepare stable oil-in-water paraffin emulsions. Colloids Surf A Physicochem Eng Asp 384(1–3):473–481
Wang W, Li N, Luo M, Zu Y, Efferth T (2012) Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components. Molecules 17(3):2704–2713
Winslow LC, Kroll DJ (1998) Herbs as medicines. Arch Intern Med 158(20):2192–2199
Zaidan MR, Noor Rain A, Badrul AR, Adlin A, Norazah A, Zakiah I (2005) In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. Trop Biomed 22(2):165–170
Zhang H, Ran X, Hu CL, Qin LP, Lu Y, Peng C (2012) Therapeutic effects of liposome-enveloped Ligusticum chuanxiong essential oil on hypertrophic scars in the rabbit ear model. PLoS One 7(2):e31157
Zuraini Z, Yoga Latha L, Suryani S, Sasidharan S (2007) Anti-Candida albicans activity of crude extract of the local plant, winged beans leaf. Planter 80:653–657
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Aziz, Z.A.A., Setapar, S.H.M. (2020). Nanotechnology: An Effective Approach for Enhancing Therapeutics and Bioavailability of Phytomedicines. In: Thangadurai, D., Sangeetha, J., Prasad, R. (eds) Functional Bionanomaterials. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-41464-1_3
Download citation
DOI: https://doi.org/10.1007/978-3-030-41464-1_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-41463-4
Online ISBN: 978-3-030-41464-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)