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Tumor Microenvironment pp 67–83Cite as

Hyaluronan in the Tumor Microenvironment

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1245))

Abstract

The extracellular matrix is part of the microenvironment and its functions are associated with the physical and chemical properties of the tissue. Among the extracellular components, the glycosaminoglycan hyaluronan is a key component, defining both the physical and biochemical characteristics of the healthy matrices. The hyaluronan metabolism is strictly regulated in physiological conditions, but in the tumoral tissues, its expression, size and binding proteins interaction are dysregulated. Hyaluronan from the tumor microenvironment promotes tumor cell proliferation, invasion, immune evasion, stemness alterations as well as drug resistance. This chapter describes data regarding novel concepts of hyaluronan functions in the tumor. Additionally, we discuss potential clinical applications of targeting HA metabolism in cancer therapy.

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  1. Laboratorio de Microambiente Tumoral, Centro de Investigaciones Básicas y Aplicadas (CIBA), Universidad Nacional de la Pcia. de Bs. As. Centro de Investigaciones y Transferencia del Noroeste de la Pcia. de Bs. As. (CIT NOBA, UNNOBA-CONICET), Junín, Buenos Aires, Argentina

    Fiorella Mercedes Spinelli, Daiana Lujan Vitale, Ina Sevic & Laura Alaniz

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  1. Fiorella Mercedes Spinelli
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  2. Daiana Lujan Vitale
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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA

    Alexander Birbrair

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Spinelli, F.M., Vitale, D.L., Sevic, I., Alaniz, L. (2020). Hyaluronan in the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1245. Springer, Cham. https://doi.org/10.1007/978-3-030-40146-7_3

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