Abstract
Over 150 years have passed since the link between inflammation and cancer was first hypothesized, and this relationship is now widely accepted. Inflammation has been described as an important player in all stages in the process of carcinogenesis, and anti-inflammatory drugs have consistently demonstrated cancer chemopreventive activity in various animal models. Considering the global cancer burden and the difficulty to treat most cancers, the development of such a preventive strategy using readily available anti-inflammatory drugs is highly appealing. However, most existing anti-inflammatory drugs come with serious side effects (gastrointestinal bleeding for NSAIDs, cardiotoxicity for COX-2 inhibitors) that would hamper their long-term use in large populations at risk of cancer development. In this context, important efforts have been made by both academia and industry to discover new potent and safe anti-inflammatory compounds with cancer chemopreventive properties. Natural reservoirs are of high interest in support of this prospect, owing to their richness and the chemical diversity they offer. The present chapter recapitulates the main preclinical and clinical advances on the search for anti-inflammatory cancer chemopreventive compounds.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Aggarwal BB (2004) Nuclear factor-κB: the enemy within. Cancer Cell 6:203–208
Aggarwal BB, Sung B (2011) NF-κB in cancer: a matter of life and death. Cancer Discov 1:469–471
Aggarwal BB, Bhardwaj A, Aggarwal RS et al (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24:2783–2840
Barnes PJ, Karin M (1997) Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066–1071
Ben-Neriah Y, Karin M (2011) Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol 12:715–723
Berge G, Øvrebø S, Eilertsen E et al (2004) Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene. Br J Cancer 91:1380–1383
Bettuzzi S, Brausi M, Rizzi F et al (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 66:1234–1240
Bishayee A (2009) Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev Res 2:409–418
Brinkhuizen T, Frencken KJA, Nelemans PJ et al (2016) The effect of topical diclofenac 3% and calcitriol 3 μg/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): a phase II, randomized controlled trial. J Am Acad Dermatol 75:126–134
Cipolla BG, Mandron E, Lefort JM et al (2015) Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res 8:712–719
Clamon G (2015) Chemoprevention and screening for lung cancer: changing our focus to former smokers. Clin Lung Cancer 16:1–5
Cruz-Correa M, Hylind LM, Marrero JH et al (2018) Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. Gastroenterology 155:668–673
Curry EA, Murry DJ, Yoder C et al (2004) Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Investig New Drugs 22:299–305
Cuzick J (2017) Preventive therapy for cancer. Lancet Oncol 18:e472–e482
Dannenberg AJ, Altorki NK, Boyle JO et al (2001) Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol 2:544–551
Deeken JF, Wang H, Hartley M et al (2018) A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies. Cancer Chemother Pharmacol 81:587–596
Dhillon N, Aggarwal BB, Newman RA et al (2008) Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14:4491–4499
Dostal AM, Samavat H, Bedell S et al (2015) The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial. Food Chem Toxicol 83:26–35
Elshaer M, Chen Y, Wang XJ, Tang X (2018) Resveratrol: an overview of its anti-cancer mechanisms. Life Sci 207:340–349
Ghantous A, Gali-Muhtasib H, Vuorela H et al (2010) What made sesquiterpene lactones reach cancer clinical trials? Drug Discov Today 15:668–678
Ghantous A, Sinjab A, Herceg Z, Darwiche N (2013) Parthenolide: from plant shoots to cancer roots. Drug Discov Today 18:894–905
Gravitz L (2011) Chemoprevention: first line of defence. Nature 471:S5–S7
Greenberg AK, Hu J, Basu S et al (2002) Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators. Am J Respir Cell Mol Biol 27:320–328
Greenberg AK, Tsay J-C, Tchou-Wong K-M et al (2013) Chemoprevention of lung cancer: prospects and disappointments in human clinical trials. Cancers 5:131–148
Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883–899
Gründemann C, Huber R (2018) Chemoprevention with isothiocyanates – from bench to bedside. Cancer Lett 414:26–33
Guo Y, Zhi F, Chen P et al (2017) Green tea and the risk of prostate cancer. Medicine 96:e6426
Hecht SS, Kenney PM, Wang M et al (1999) Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in a/J mice. Cancer Lett 137:123–130
Henney JE (2000) Celecoxib indicated for FAP. JAMA 283:1131–1131
Ho WE, Peh HY, Chan TK, Wong WSF (2014) Artemisinins: pharmacological actions beyond anti-malarial. Pharmacol Ther 142:126–139
Jang M, Cai L, Udeani GO et al (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218–220
Jansen FH, Adoubi I, Comoe JCK et al (2011) First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers. Anticancer Res 31:4417–4422
Jiang Z, Chen K, Cheng L et al (2017) Resveratrol and cancer treatment: updates. Ann N Y Acad Sci 1403:59–69
Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-κB system: a treasure trove for drug development. Nat Rev Drug Discov 3:17–26
Kumar NB, Pow-Sang J, Egan KM et al (2015) Randomized, placebo-controlled trial of green tea catechins for prostate cancer prevention. Cancer Prev Res 8:879–887
Kumar NB, Pow-Sang J, Spiess PE et al (2016) Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins. Oncotarget 7:70794–70802
Kurus M, Firat Y, Cetin A et al (2009) The effect of resveratrol in tracheal tissue of rats exposed to cigarette smoke. Inhal Toxicol 21:979–984
Lawrence T (2009) The nuclear factor NF-κB pathway in inflammation. Cold Spring Harb Perspect Biol 1:a001651
Li ZG, Hong T, Shimada Y et al (2002) Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 23:1531–1536
Lin K-T, Wang L-H (2016) New dimension of glucocorticoids in cancer treatment. Steroids 111:84–88
Liu S-F, Kuo H-C, Lin M-C et al (2017) Inhaled corticosteroids have a protective effect against lung cancer in female patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study. Oncotarget 8:29711–29721
Mao JT, Roth MD, Fishbein MC et al (2011) Lung cancer chemoprevention with celecoxib in former smokers. Cancer Prev Res 4:984–993
McNeil JJ, Woods RL, Nelson MR et al (2018) Effect of aspirin on disability-free survival in the healthy elderly. New Engl J Med 379:1499–1508
Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454:428–435
Meylan E, Dooley AL, Feldser DM et al (2009) Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma. Nature 462:104–107
Monteillier A, Voisin A, Furrer P et al (2018) Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice. Sci Rep 8:14257
Nam N-H (2006) Naturally occurring NF-κB inhibitors. Mini Rev Med Chem 6:945–951
Nelson CG (2011) Diclofenac gel in the treatment of actinic keratoses. Ther Clin Risk Manag 7:207–211
Oshima M, Dinchuk JE, Kargman SL et al (1996) Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87:803–809
Pavan AR, Silva GD, Jornada DH et al (2016) Unraveling the anticancer effect of curcumin and resveratrol. Nutrients 8:628
Pezzuto JM (2019) Resveratrol: twenty years of growth, development and controversy. Biomol Ther 27:1–14
Rabadi LA, Bergan R (2016) A way forward for cancer chemoprevention: think local. Cancer Prev Res 10:14–35
Ramasamy K, Dwyer-Nield LD, Serkova NJ et al (2011) Silibinin prevents lung tumorigenesis in wild-type but not in iNOS−/− mice: potential of real-time micro-CT in lung cancer chemoprevention studies. Clin Cancer Res 17:753–761
Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids—new mechanisms for old drugs. N Engl J Med 353:1711–1723
Samavat H, Ursin G, Emory TH et al (2017) A randomized controlled trial of green tea extract supplementation and mammographic density in postmenopausal women at increased risk of breast cancer. Cancer Prev Res 10:710–718
Saud SM, Li W, Morris NL et al (2014) Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. Carcinogenesis 35:2778–2786
Sen R, Baltimore D (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705–716
Sengottuvelan M, Nalini N (2006) Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development. Br J Nutr 96:145–153
Shen B (2015) A new golden age of natural products drug discovery. Cell 163:1297–1300
Takahashi H, Ogata H, Nishigaki R et al (2010) Tobacco smoke promotes lung tumorigenesis by triggering IKKβ and JNK1 dependent inflammation. Cancer Cell 17:89–97
Tang X, Liu D, Shishodia S et al (2006) Nuclear factor-κB (NF-κB) is frequently expressed in lung cancer and preneoplastic lesions. Cancer 107:2637–2646
The United States Preventive Services Task Force (2018) Task force releases recommendations on aspirin to prevent colon cancer, heart disease. https://www.cancer.org/latest-news/task-force-releases-recommendations-on-aspirin-to-prevent-colon-cancer-heart-disease.html.
Tome-Carneiro J, Larrosa M, Gonzalez-Sarrias A et al (2013) Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des 19:6064–6093
Vannini F, Kashfi K, Nath N (2015) The dual role of iNOS in cancer. Redox Biol 6:334–343
von Hagens C, Walter-Sack I, Goeckenjan M et al (2017) Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2). Breast Cancer Res Treat 164:359–369
Wahab A, Gao K, Jia C et al (2017) Significance of resveratrol in clinical management of chronic diseases. Molecules 22:1329
Walle T, Hsieh F, DeLegge MH et al (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32:1377–1382
Yang CS, Wang H (2016) Cancer preventive activities of tea catechins. Molecules 21:1679
Yao R, Wang Y, Lemon WJ et al (2004) Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions. Oncogene 23:7746–7752
Yuan J-M, Stepanov I, Murphy SE et al (2016) Clinical trial of 2-phenethyl isothiocyanate as an inhibitor of metabolic activation of a tobacco-specific lung carcinogen in cigarette smokers. Cancer Prev Res 9:396–405
Zhang D, Qiu L, Jin X et al (2009) Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo. Mol Cancer Res 7:1139–1149
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Monteillier, A., Cuendet, M. (2020). The Use of Anti-Inflammatory Agents for Cancer Chemoprevention. In: Pezzuto, J., Vang, O. (eds) Natural Products for Cancer Chemoprevention. Springer, Cham. https://doi.org/10.1007/978-3-030-39855-2_17
Download citation
DOI: https://doi.org/10.1007/978-3-030-39855-2_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-39854-5
Online ISBN: 978-3-030-39855-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)