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A Critical Appraisal on the Epidemiological Evidence Linking Perinatal Inflammation and Risk of Psychosis

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Perinatal Inflammation and Adult Psychopathology

Part of the book series: Progress in Inflammation Research ((PIR,volume 84))

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Abstract

Since the dawn of psychiatry as a medical discipline, physicians and researchers struggle with theories that could explain the origin of schizophrenia. Among several hypotheses, perinatal inflammation remains one of great importance not only for the schizophrenia syndrome but also to major neurodevelopmental disorders as autism. In this chapter, a summary of the evidence and relevance to support neuroinflammation as an important factor increasing the risk for schizophrenia is highlighted. The limitations of this theory are discussed together with other synergistic factors that could influence the diathesis of schizophrenia.

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Authors and Affiliations

  1. Nucleo de Pesquisa e Desenvolvimento de Medicamentos, Federal University of Ceara, Fortaleza, Brazil

    Lia Sanders & David De Lucena

  2. Psychology Department, Universidade De Fortaleza, Fortaleza, Brazil

    Felicia Gabler

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  1. Lia Sanders
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  2. Felicia Gabler
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  3. David De Lucena
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Correspondence to David De Lucena .

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Editors and Affiliations

  1. Psychiatry and Behavioral Sciences, UT Health Houston, Houston, TX, USA

    Antonio L. Teixeira

  2. Physiology and Pharmacology, Universidade Federal do Ceara, Fortaleza, Brazil

    Danielle Macedo

  3. Psychiatry, University of Munster, Munster, Germany

    Bernhard T. Baune

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Sanders, L., Gabler, F., De Lucena, D. (2020). A Critical Appraisal on the Epidemiological Evidence Linking Perinatal Inflammation and Risk of Psychosis. In: Teixeira, A.L., Macedo, D., Baune, B.T. (eds) Perinatal Inflammation and Adult Psychopathology. Progress in Inflammation Research, vol 84. Springer, Cham. https://doi.org/10.1007/978-3-030-39335-9_8

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