Skip to main content

Abstract

Minimally invasive hepatectomy remains a burgeoning field. The increase in utilization of minimal access approaches for these complex cases has resulted in an increase in the number of technologies available to improve the safety and efficacy of these procedures. Near infrared fluorescence imaging is one such technology that has been shown to be successful in improving intraoperative identification of anatomic structures as well as lines of transection during resection. Applications of this technology include intraoperative administration via direct access puncture to hepatic arterial inflow versus peripheral intravenous administration just after inflow ligation to provide fluorescent guided margins for transection. A widely used approach applies preoperative administration of indocyanine green (ICG) to allow for intraoperative identification of major biliary system structures during dissection. With the use of ICG and near-infrared fluorescence-enabled optical devices, this technology has been applied to both robotic and laparoscopic approaches for the full gamut of hepatic resections. This technology has proven to be effective and will continue to provide novel techniques to improve the accuracy and safety of minimally invasive hepatectomies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Yohanathan L, Cleary SP. Minimally invasive management of secondary liver cancer. Surg Oncol Clin N Am. 2019;28(2):229–41. Epub 2019/01/07. https://doi.org/10.1016/j.soc.2018.11.003. PubMed PMID: 30851825.

    Article  PubMed  Google Scholar 

  2. Swaid F, Geller DA. Minimally invasive primary liver cancer surgery. Surg Oncol Clin N Am. 2019;28(2):215–27. Epub 2019/02/02. https://doi.org/10.1016/j.soc.2018.11.002. PubMed PMID: 30851824.

    Article  PubMed  Google Scholar 

  3. Nguyen KT, Gamblin TC, Geller DA. World review of laparoscopic liver resection-2,804 patients. Ann Surg. 2009;250(5):831–41. https://doi.org/10.1097/SLA.0b013e3181b0c4df. PubMed PMID: 19801936.

    Article  PubMed  Google Scholar 

  4. Melandro F, Giovanardi F, Hassan R, Larghi Laureiro Z, Ferri F, Rossi M, et al. Minimally invasive approach in the setting of ALPPS procedure: a systematic review of the literature. J Gastrointest Surg. 2019. Epub 2019/06/13. https://doi.org/10.1007/s11605-018-04092-x. PubMed PMID: 31197682.

  5. Lee B, Choi Y, Han HS, Yoon YS, Cho JY, Kim S, et al. Comparison of pure laparoscopic and open living donor right hepatectomy after a learning curve. Clin Transplant. 2019. Epub 2019/08/01. https://doi.org/10.1111/ctr.13683. PubMed PMID: 31368582.

  6. Park J, Kwon DCH, Choi GS, Kim SJ, Lee SK, Kim JM, et al. Safety and risk factors of pure laparoscopic living donor right hepatectomy: comparison to open technique in propensity score-matched analysis. Transplantation. 2019. Epub 2019/06/24. https://doi.org/10.1097/TP.0000000000002834. PubMed PMID: 31283680.

  7. Brown KM, Geller DA. What is the learning curve for laparoscopic major hepatectomy? J Gastrointest Surg. 2016;20(5):1065–71. Epub 2016/03/08. https://doi.org/10.1007/s11605-016-3100-8. PubMed PMID: 26956007.

    Article  PubMed  Google Scholar 

  8. Hu L, Yao L, Li X, Jin P, Yang K, Guo T. Effectiveness and safety of robotic-assisted versus laparoscopic hepatectomy for liver neoplasms: a meta-analysis of retrospective studies. Asian J Surg. 2018;41(5):401–16. Epub 2017/09/12. https://doi.org/10.1016/j.asjsur.2017.07.001. PubMed PMID: 28912048.

    Article  PubMed  Google Scholar 

  9. Tsung A, Geller DA, Sukato DC, Sabbaghian S, Tohme S, Steel J, et al. Robotic versus laparoscopic hepatectomy: a matched comparison. Ann Surg. 2014;259(3):549–55. https://doi.org/10.1097/SLA.0000000000000250. PubMed PMID: 24045442.

    Article  PubMed  Google Scholar 

  10. Kingham TP, Leung U, Kuk D, Gönen M, D’Angelica MI, Allen PJ, et al. Robotic liver resection: a case-matched comparison. World J Surg. 2016;40(6):1422–8. https://doi.org/10.1007/s00268-016-3446-9. PubMed PMID: 26913732; PubMed Central PMCID: PMCPMC4870111.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kudo H, Ishizawa T, Tani K, Harada N, Ichida A, Shimizu A, et al. Visualization of subcapsular hepatic malignancy by indocyanine-green fluorescence imaging during laparoscopic hepatectomy. Surg Endosc. 2014;28(8):2504–8. Epub 2014/02/25. https://doi.org/10.1007/s00464-014-3468-z. PubMed PMID: 24566751.

    Article  PubMed  Google Scholar 

  12. Urade T, Sawa H, Iwatani Y, Abe T, Fujinaka R, Murata K, et al. Laparoscopic anatomical liver resection using indocyanine green fluorescence imaging. Asian J Surg. 2019. Epub 2019/04/28. https://doi.org/10.1016/j.asjsur.2019.04.008. PubMed PMID: 31043331.

  13. Ishizawa T, Gumbs AA, Kokudo N, Gayet B. Laparoscopic segmentectomy of the liver: from segment I to VIII. Ann Surg. 2012;256(6):959–64. https://doi.org/10.1097/SLA.0b013e31825ffed3.

    Article  PubMed  Google Scholar 

  14. Verbeek FP, Schaafsma BE, Tummers QR, van der Vorst JR, van der Made WJ, Baeten CI, et al. Optimization of near-infrared fluorescence cholangiography for open and laparoscopic surgery. Surg Endosc. 2014;28(4):1076–82. https://doi.org/10.1007/s00464-013-3305-9. PubMed PMID: 24232054; PubMed Central PMCID: PMCPMC4021038.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Ishizawa T, Bandai Y, Kokudo N. Fluorescent cholangiography using indocyanine green for laparoscopic cholecystectomy: an initial experience. Arch Surg. 2009;144(4):381–2. https://doi.org/10.1001/archsurg.2009.9.

    Article  PubMed  Google Scholar 

  16. Ishizawa T, Saiura A, Kokudo N. Clinical application of indocyanine green-fluorescence imaging during hepatectomy. Hepatobiliary Surg Nutr. 2016;5(4):322–8. https://doi.org/10.21037/hbsn.2015.10.01. PubMed PMID: 27500144; PubMed Central PMCID: PMCPMC4960410.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Hong SK, Lee KW, Kim HS, Yoon KC, Ahn SW, Choi JY, et al. Optimal bile duct division using real-time indocyanine green near-infrared fluorescence cholangiography during laparoscopic donor hepatectomy. Liver Transpl. 2017;23(6):847–52. https://doi.org/10.1002/lt.24686.

    Article  PubMed  Google Scholar 

  18. Osayi SN, Wendling MR, Drosdeck JM, Chaudhry UI, Perry KA, Noria SF, et al. Near-infrared fluorescent cholangiography facilitates identification of biliary anatomy during laparoscopic cholecystectomy. Surg Endosc. 2015;29(2):368–75. Epub 2014/07/02. https://doi.org/10.1007/s00464-014-3677-5. PubMed PMID: 24986018; PubMed Central PMCID: PMCPMC4415528.

    Article  PubMed  Google Scholar 

  19. Pesce A, Latteri S, Barchitta M, Portale TR, Di Stefano B, Agodi A, et al. Near-infrared fluorescent cholangiography—real-time visualization of the biliary tree during elective laparoscopic cholecystectomy. HPB (Oxford). 2018;20(6):538–45. Epub 2017/12/29. https://doi.org/10.1016/j.hpb.2017.11.013. PubMed PMID: 29292071.

    Article  Google Scholar 

  20. Nomi T, Hokuto D, Yoshikawa T, Matsuo Y, Sho M. A novel navigation for laparoscopic anatomic liver resection using indocyanine green fluorescence. Ann Surg Oncol. 2018;25(13):3982. Epub 2018/09/14. https://doi.org/10.1245/s10434-018-6768-z. PubMed PMID: 30218249.

    Article  PubMed  Google Scholar 

  21. Mizuno T, Sheth R, Yamamoto M, Kang HS, Yamashita S, Aloia TA, et al. Laparoscopic glissonean pedicle transection (Takasaki) for negative fluorescent counterstaining of segment 6. Ann Surg Oncol. 2017;24(4):1046–7. Epub 2016/12/19. https://doi.org/10.1245/s10434-016-5721-2. PubMed PMID: 27995453.

    Article  PubMed  Google Scholar 

  22. Schols RM, Bouvy ND, Masclee AA, van Dam RM, Dejong CH, Stassen LP. Fluorescence cholangiography during laparoscopic cholecystectomy: a feasibility study on early biliary tract delineation. Surg Endosc. 2013;27(5):1530–6. Epub 2012/10/18. https://doi.org/10.1007/s00464-012-2635-3. PubMed PMID: 23076461.

    Article  PubMed  Google Scholar 

  23. Mitsuhashi N, Kimura F, Shimizu H, Imamaki M, Yoshidome H, Ohtsuka M, et al. Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery. J Hepatobiliary Pancreat Surg. 2008;15(5):508–14. Epub 2008/10/04. https://doi.org/10.1007/s00534-007-1307-5. PubMed PMID: 18836805.

    Article  PubMed  Google Scholar 

  24. Speich R, Saesseli B, Hoffmann U, Neftel KA, Reichen J. Anaphylactoid reactions after indocyanine-green administration. Ann Intern Med. 1988;109(4):345–6. https://doi.org/10.7326/0003-4819-109-4-345_2. PubMed PMID: 3395048.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David A. Iannitti .

Editor information

Editors and Affiliations

Electronic Supplementary Material

Robotic left hepatectomy hilar dissection using near-infrared fluorescence technology (MP4 638526 kb)

Robotic right hepatectomy hilar dissection using near-infrared fluorescence technology (MP4 316205 kb)

Robotic right posterior sectionectomy hilar dissection using near-infrared fluorescence technology (MP4 211809 kb)

Laparoscopic central hepatectomy using negative near-infrared fluorescence to determine transection margins (MP4 406780 kb)

Robotic right hepatectomy using negative near-infrared fluorescence to determine transection margins (MP4 292789 kb)

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sulzer, J.K., Salibi, P.N., Martinie, J.B., Iannitti, D.A. (2020). Minimally Invasive Hepatectomy. In: Aleassa, E., El-Hayek, K. (eds) Video Atlas of Intraoperative Applications of Near Infrared Fluorescence Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-38092-2_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-38092-2_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-38091-5

  • Online ISBN: 978-3-030-38092-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics