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Infectious and Inflammatory Mimickers of Hematopoietic Disorders in the Liver and Spleen

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Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver

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Abstract

Benign or malignant diseases confined to the liver can be associated with inflammation, including lymphoid or plasmacytic infiltrate, and can rarely mimic neoplastic hematopoietic disorders. These differential diagnoses have received limited attention in the literature. Understanding the patterns of liver histology caused by lymphoma and various non-neoplastic inflammatory pathologies is essential, as the differential diagnosis varies depending on whether an inflammatory infiltrate primarily involves portal tracts, primarily involves sinusoids, or forms a discrete mass lesion.

The differential diagnosis for pathologic enlargement of the spleen is broad. As a hematopoietic organ, the spleen is a site of primary lymphoma, but also manifests pathologic abnormalities in a variety of infectious diseases, hematologic disorders, and systemic inflammatory disorders that may mimic primary or secondary involvement by a hematopoietic malignancy.

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Author information

Authors and Affiliations

  1. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Raul S. Gonzalez

  2. Department of Pathology and Laboratory Medicine, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, NY, USA

    Andrew G. Evans

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  1. Raul S. Gonzalez
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  2. Andrew G. Evans
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Correspondence to Andrew G. Evans .

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Editors and Affiliations

  1. Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA

    Ling Zhang

  2. Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA

    Haipeng Shao

  3. Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Serhan Alkan

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Gonzalez, R.S., Evans, A.G. (2020). Infectious and Inflammatory Mimickers of Hematopoietic Disorders in the Liver and Spleen. In: Zhang, L., Shao, H., Alkan, S. (eds) Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver. Springer, Cham. https://doi.org/10.1007/978-3-030-37708-3_21

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  • DOI: https://doi.org/10.1007/978-3-030-37708-3_21

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  • Online ISBN: 978-3-030-37708-3

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