Abstract
The workup consists of taking a thorough history and physical examination and assessing the nutritional status and functional status in addition to conducting a dental evaluation, multiple imaging modalities at the primary site and at distant sites, and biopsy of the lesion. A thorough and preoperative medical, anesthetic, and surgical assessment is to be undertaken to identify pathophysiology and determine perioperative risk stratification, anesthetic management, medical management, surgical management, and medical optimization. Based on these assessments, the oncology team would determine if the patient is healthy enough to withstand treatment, and the decision is based on the interplay of existing comorbidities, patient age, functional status, performance status, and frailty. The eventual goal is to integrate all of this information and to clinically stage the patient and develop a treatment plan consistent with the patient’s treatment goals and tolerance for any side effects of treatment.
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References
Rennemo E, Zätterström U, Boysen M. Synchronous second primary tumors in 2,016 head and neck cancer patients: role of symptom-directed panendoscopy. Laryngoscope. 2011;121(2):304–9.
Merritt RM, et al. Detection of cervical metastasis: a meta-analysis comparing computed tomography with physical examination. Arch Otolaryngol Head Neck Surg. 1997;123(2):149–52.
Babshet M, et al. Efficacy of oral brush cytology in the evaluation of the oral premalignant and malignant lesions. J Cytol. 2011;28(4):165–72.
Gupta S, et al. Clinical correlative study on early detection of oral cancer and precancerous lesions by modified oral brush biopsy and cytology followed by histopathology. J Cancer Res Ther. 2014;10(2):232–8.
Rhodus NL, Kerr AR, Patel K. Oral cancer: leukoplakia, premalignancy, and squamous cell carcinoma. Dent Clin N Am. 2014;58(2):315–40.
Rashid A, Warnakulasuriya S. The use of light-based (optical) detection systems as adjuncts in the detection of oral cancer and oral potentially malignant disorders: a systematic review. J Oral Pathol Med. 2015;44(5):307–28.
Baeten J, et al. Chairside molecular imaging of aberrant glycosylation in subjects with suspicious oral lesions using fluorescently labeled wheat germ agglutinin. Head Neck. 2018;40(2):292–301.
Baeten J, et al. Molecular imaging of oral premalignant and malignant lesions using fluorescently labeled lectins. Transl Oncol. 2014;7(2):213–20.
Portugal LC, Wilson KM, Biddinger PW, et al. The role of toluidine blue in assessing margin status after resection of squamous cell carci-nomas of the upper aerodigestive tract. Arch Otolaryngol Head Neck Surg. 1996;122:517–9.
Schilling C, et al. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer. Eur J Cancer. 2015;51(18):2777–84.
Blatt S, et al. Diagnosing oral squamous cell carcinoma: how much imaging do we really need? A review of the current literature. J Craniomaxillofac Surg. 2016;44(5):538–49.
Sarrion Perez MG, et al. Utility of imaging techniques in the diagnosis of oral cancer. J Craniomaxillofac Surg. 2015;43(9):1880–94.
Li-Jen L, et al. Detection of cervical lymph node metastasis in head and neck cancer patients with clinically N0 neck-a meta-analysis comparing different imaging modalities. BMC Cancer. 2012;12(1):236–42.
Rohde M, et al. 18F-fluoro-deoxy-glucose-positron emission tomography/computed tomography in diagnosis of head and neck squamous cell carcinoma: a systematic review and meta-analysis. Eur J Cancer. 2014;50(13):2271–9.
Xiao Y, et al. The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma: a meta-analysis. Nucl Med Commun. 2015;36(4):312–8.
Chaukar D, et al. Relative value of ultrasound, computed tomography and positron emission tomography imaging in the clinically node-negative neck in oral cancer. Asia Pac J Clin Oncol. 2016;12(2):e332–8.
Levett DZH, Grocott MPW. Cardiopulmonary exercise testing, prehabilitation, and Enhanced Recovery After Surgery (ERAS). Can J Anaesth. 2015;62:131–42.
Paleri V, et al. Comorbidity in head and neck cancer: a critical appraisal and recommendations for practice. Oral Oncol. 2010;46(10):712–9.
Bøje CR, et al. The impact of comorbidity on outcome in 12 623 Danish head and neck Cancer patients: a population based study from the DAHANCA database. Acta Oncol. 2013;52(2):285–93.
Borggreven PA, et al. Comorbid condition as a prognostic factor for complications in major surgery of the oral cavity and oropharynx with microvascular soft tissue reconstruction. Head Neck. 2003;25(10):808–15.
de Cassia Braga Ribeiro K, Kowalski LP, Latorre Mdo R. Perioperative complications, comorbidities, and survival in oral or oropharyngeal cancer. Arch Otolaryngol Head Neck Surg. 2003;129(2):219–28.
de Melo GM, et al. Risk factors for postoperative complications in oral cancer and their prognostic implications. Arch Otolaryngol Head Neck Surg. 2001;127(7):828–33.
Shuman AG, et al. Optimizing perioperative management of geriatric patients with head and neck cancer. Head Neck. 2014;36(5):743–9.
Adams P, et al. Frailty as a predictor of morbidity and mortality in inpatient head and neck surgery. JAMA Otolaryngol Head Neck Surg. 2013;139(8):783–9.
Maione P, et al. Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol. 2005;23(28):6865–72.
CorrĂªa GTB, et al. Analysis of ECOG performance status in head and neck squamous cell carcinoma patients: association with sociodemographical and clinical factors, and overall survival. Support Care Cancer. 2012;20(11):2679–85.
van Kan GA, et al. The assessment of frailty in older adults. Clin Geriatr Med. 2010;26(2):275–86.
Soeters PB, et al. A rational approach to nutritional assessment. Clin Nutr. 2008;27(5):706–16.
Righini CA, et al. Assessment of nutritional status at the time of diagnosis in patients treated for head and neck cancer. Eur Ann Otorhinolaryngol Head Neck Dis. 2013;130(1):8–14.
Alshadwi A, et al. Nutritional considerations for head and neck cancer patients: a review of the literature. J Oral Maxillofac Surg. 2013;71(11):1853–60.
Saroul N, et al. Which assessment method of malnutrition in head and neck cancer? Otolaryngol Head Neck Surg. 2018;158:1065. https://doi.org/10.1177/0194599818755995.
Kaderbay A, et al. Malnutrition and refeeding syndrome prevention in head and neck cancer patients: from theory to clinical application. Eur Arch Otorhinolaryngol. 2018;275(5):1049–58.
Agarwal E, et al. Malnutrition and poor food intake are associated with prolonged hospital stay, frequent readmissions, and greater in-hospital mortality: results from the nutrition care day survey 2010. Clin Nutr. 2013;32(5):737–45.
Friedli N, et al. Revisiting the refeeding syndrome: results of a systematic review. Nutrition. 2017;35:151–60.
Rohrer S, Dietrich JW. Refeeding syndrome: a review of the literature. Z Gastroenterol. 2014;52(6):593–600.
Gupta K, et al. Clinical assessment scoring system for tracheostomy (CASST) criterion: objective criteria to predict pre-operatively the need for a tracheostomy in head and neck malignancies. J Craniomaxillofac Surg. 2016;44(9):1310–3.
Miller EH, Quinn AI. Dental considerations in the management of head and neck cancer patients. Otolaryngol Clin N Am. 2006;39(2):319–29.
Korc-Grodzicki B, et al. Surgical considerations in older adults with cancer. J Clin Oncol. 2014;32(24):2647–53.
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Awadallah, M., Patel, K., Kademani, D. (2020). General Workup Prior to the Treatment Phase of Oral Cancer. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_19
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DOI: https://doi.org/10.1007/978-3-030-32316-5_19
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