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Intragastric Occupying Space Devices

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Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy

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Abstract

In 2016, 39% of adults were overweight, and about 13% of the world’s adult population were obese. Obesity represents a growing global public health despite the availability of diet and lifestyle counseling, pharmacologic therapy, and bariatric surgery. Endoscopic bariatric therapies (EBTs) encompass a wide range of devices requiring flexible endoscopy for placement or removal and procedures performed via flexible endoscopy for the treatment of obesity. Current primary EBTs can be classified as space-occupying or non-space-occupying devices (restrictive, bypass, or aspiration therapy).

Intragastric balloons (IBG) act as space-occupying devices, reducing stomach capacity and inducing satiety by several mechanisms. To date, ORBERA® Intragastric Balloon System, RESHAPE DUO Intragastric Balloon, and OBALON Balloon System are approved by the US Food and Drug Administration (FDA) based on demonstrated safety and efficacy in randomized controlled trials (RCTs). Two other balloons are currently under FDA investigation: the Spatz Adjustable (Spatz Medical, Great Neck, NY) and the Elipse Balloon (Allurion, Natick, MA).

TransPyloric Shuttle consists of two bulbs connected by a flexible silicone tether which facilitates partial gastric obstruction resulting in delayed gastric emptying and early satiety.

Space-occupying devices represent a good therapeutic option in the treatment of morbid patients, above all if used as obesity prevention tool. Some of those devices need to demonstrate greater reliability in terms of safety.

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Author information

Authors and Affiliations

  1. Department of Surgical Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy

    Alfredo Genco & Loredana Gualtieri

  2. Department of Experimental Medicine, RU of Food Science and Human Nutrition, Sapienza University of Rome, Rome, Italy

    Ilaria Ernesti

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  1. Alfredo Genco
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  2. Ilaria Ernesti
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  3. Loredana Gualtieri
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Corresponding author

Correspondence to Alfredo Genco .

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Editors and Affiliations

  1. Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, MILANO, Milano, Italy

    Pier Alberto Testoni

  2. Digestive Diseases Center, Showa University Hospital, Tokyo, Japan

    Haruhiro Inoue

  3. Div. of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA

    Michael B. Wallace

Section Editor information

  1. Gastrointestinal Endoscopy Unit, Vita‐Salute San Raffaele University, Milan, Italy

    Pier Alberto Testoni

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Genco, A., Ernesti, I., Gualtieri, L. (2021). Intragastric Occupying Space Devices. In: Testoni, P.A., Inoue, H., Wallace, M.B. (eds) Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-29964-4_43-2

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  • DOI: https://doi.org/10.1007/978-3-030-29964-4_43-2

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Chapter history

  1. Latest

    Intragastric Occupying Space Devices
    Published:
    23 January 2022

    DOI: https://doi.org/10.1007/978-3-030-29964-4_43-2

  2. Original

    Intragastric Occupying Space Devices
    Published:
    03 August 2021

    DOI: https://doi.org/10.1007/978-3-030-29964-4_43-1

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