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Stem Cell Delivery Systems and Devices - Spraying

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Stem Cell-Based Therapy for Lung Disease

Abstract

Despite huge progress in interrogating the benefits of stem cells for lung diseases, more studies on optimal routes of cell delivery are required. The ability of intravenously injected stem cells to reach all parts of the lung is limited, particularly when the extracellular matrix and vasculature are damaged in various lung diseases. Hence, an alternative route of stem cell administration that delivers cells directly to the lung through the airway may provide a more adequate supply of stem cells at the site of injury. In many lung injuries and diseases, much of the damage occurs in the airway epithelium, and thus intratracheal administration of the stem cells directly delivered to the injury site may be beneficial. For optimal therapeutic benefits, it is important that cells are uniformly distributed across the whole lung. The exogenous cells are required to be in a healthy state when delivered to the injured area. Therefore, there is a need to optimise the technology to deliver cells directly to airways. This chapter presents an overview of the currently available technologies for cell spraying and discusses other important parameters for successful delivery of stem cells to the lung.

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Acknowledgements

The authors acknowledge the support of Professor Daniel Weiss for his expertise and guidance in the decellularisation model. The cell transfection and bioluminescence imaging were made possible through the expertise provided by Dr. Yuen Chung and Dr. Yiwei Wang. WCh acknowledges the University of Sydney for a SOAR Fellowship.

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Authors and Affiliations

  1. Faculty of Medicine and Health, University of Sydney School of Pharmacy, Camperdown, NSW, Australia

    Sally Yunsun Kim & Wojciech Chrzanowski

  2. National Heart and Lung Institute, Imperial College London, London, UK

    Sally Yunsun Kim

  3. The University of Sydney Nano Institute, Camperdown, NSW, Australia

    Wojciech Chrzanowski

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  1. Sally Yunsun Kim
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Correspondence to Wojciech Chrzanowski .

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Editors and Affiliations

  1. The University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands

    Janette K. Burgess

  2. The University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands

    Irene H. Heijink

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Kim, S.Y., Chrzanowski, W. (2019). Stem Cell Delivery Systems and Devices - Spraying. In: Burgess, J., Heijink, I. (eds) Stem Cell-Based Therapy for Lung Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-29403-8_13

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