T Helper 17 Cells as Pathogenic Drivers of Periodontitis

Dutzan, Nicolas; Abusleme, Loreto

doi:10.1007/978-3-030-28524-1_9

T Helper 17 Cells as Pathogenic Drivers of Periodontitis

Nicolas Dutzan⁷ &
Loreto Abusleme^8,9

Conference paper

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38 Citations
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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1197))

Abstract

T helper 17 (Th17) cells were first described as a T helper subset involved in the pathogenesis of experimental autoimmune inflammation. Since then, these cells have been described as orchestrators of immunopathology in several human inflammatory conditions including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. More recently, the crucial role of Th17 cells in the regulation of immunity and protection of barrier sites has been unveiled. In the present work, we review the available evidence regarding Th17 cells in health and disease with a focus on the oral mucosa and their role in periodontitis pathogenesis. Recent mechanistic studies in animal models have demonstrated that interleukin-17A (IL-17A) and Th17 cells are critical mediators for alveolar bone destruction during periodontal inflammation. Observations in a cohort of patients with naturally occurring impaired Th17 cell differentiation supported these findings. However, interventional studies are needed to conclusively implicate Th17 cells in the immunopathogenesis of human alveolar bone and tissue destruction that characterize periodontitis.

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Acknowledgments

This work was partly funded by the Chilean government through FONDECYT # 11180389 (to N.D) and FONDECYT # 11180505 (to L.A).

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Authors and Affiliations

Oral Mucosal Immunology Section, Craniofacial and Translational Research Laboratory, Faculty of Dentistry, University of Chile, Santiago, Chile
Nicolas Dutzan
Laboratory of Oral Microbiology, Faculty of Dentistry, University of Chile, Santiago, Chile
Loreto Abusleme
Oral Microbial Ecology Section, Craniofacial and Translational Research Laboratory, Faculty of Dentistry, University of Chile, Santiago, Chile
Loreto Abusleme

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Nicolas Dutzan
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Loreto Abusleme
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Correspondence to Nicolas Dutzan .

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Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden
Georgios N. Belibasakis & Nagihan Bostanci &
Department of Microbiology, University of Pennsylvania, Penn Dental Medicine, Philadelphia, PA, USA
George Hajishengallis
King’s College London Dental Institute, London, UK
Michael A. Curtis

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Dutzan, N., Abusleme, L. (2019). T Helper 17 Cells as Pathogenic Drivers of Periodontitis. In: Belibasakis, G.N., Hajishengallis, G., Bostanci, N., Curtis, M.A. (eds) Oral Mucosal Immunity and Microbiome. Advances in Experimental Medicine and Biology, vol 1197. Springer, Cham. https://doi.org/10.1007/978-3-030-28524-1_9

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DOI: https://doi.org/10.1007/978-3-030-28524-1_9
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