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The Role of Caveolin-1 in Retinal Inflammation

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1185))

Abstract

Although the retina resides within the immune-protected ocular environment, inflammatory processes mounted in the eye can lead to retinal damage. Unchecked chronic ocular inflammation leads to retinal damage. Thus, retinal degenerative diseases that result in chronic inflammation accelerate retinal tissue destruction and vision loss. Treatments for chronic retinal inflammation involve corticosteroid administration, which has been associated with glaucoma and cataract formation. Therefore, we must consider novel, alternative treatments. Here, we provide a brief review of our current understanding of chronic innate inflammatory processes in retinal degeneration and the complex role of a putative inflammatory regulator, Caveolin-1 (Cav1). Furthermore, we suggest that the complex role of Cav1 in retinal inflammatory modulation is likely dictated by cell type-specific subcellular localization.

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Author information

Authors and Affiliations

  1. Departments of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Jami M. Gurley & Michael H. Elliott

  2. Dean A. McGee Eye Institute, Oklahoma City, OK, USA

    Jami M. Gurley & Michael H. Elliott

  3. Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Michael H. Elliott

  4. Departments of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Michael H. Elliott

Authors
  1. Jami M. Gurley
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  2. Michael H. Elliott
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Corresponding authors

Correspondence to Jami M. Gurley or Michael H. Elliott .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Duke University, Durham, NC, USA

    Catherine Bowes Rickman

  2. Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  3. Health Sciences Center, University of Oklahoma, Oklahoma City, OK, USA

    Robert E. Anderson

  4. Ophthalmology, University of Florida, Gainesville, FL, USA

    John D. Ash

  5. Beckman Vision Center, University of California, San Francisco, San Fancisco, CA, USA

    Matthew M. LaVail

  6. Department of Ophthalmology, Case Western Reserve University, Cleveland, OH, USA

    Joe G. Hollyfield

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Gurley, J.M., Elliott, M.H. (2019). The Role of Caveolin-1 in Retinal Inflammation. In: Bowes Rickman, C., Grimm, C., Anderson, R., Ash, J., LaVail, M., Hollyfield, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 1185. Springer, Cham. https://doi.org/10.1007/978-3-030-27378-1_28

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