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Evidence-Based Critical Care pp 773–777Cite as

Management of Severe Skin Eruptions

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Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a continuum of severe mucocutaneous eruptions associated with significant morbidity. The condition is characterized by diffuse erythematous purpuric macules or flat targetoid lesions that evolve into vesicles and bullae followed by skin sloughing. The skin changes are nearly always associated with mucosal involvement. SJS/TEN is typically induced by medication use, but can be triggered by bacterial or viral infections. Management involves removal of the offending agent and supportive care. The evidence supporting corticosteroids and IVIG is lacking, although evidence of new therapies is emerging. In this chapter, the diagnosis and management of SJS/TEN will be discussed. The conflicting data on systemic therapy is addressed.

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Authors and Affiliations

  1. Department of Pulmonary & Critical Care Medicine, University of Vermont Medical Center, Burlington, VT, USA

    Katherine Menson & Garth W. Garrison

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  1. Katherine Menson
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  2. Garth W. Garrison
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Correspondence to Garth W. Garrison .

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Editors and Affiliations

  1. Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA

    Robert C. Hyzy

  2. Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA

    Jakob McSparron

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Menson, K., Garrison, G.W. (2020). Management of Severe Skin Eruptions. In: Hyzy, R.C., McSparron, J. (eds) Evidence-Based Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-030-26710-0_103

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  • DOI: https://doi.org/10.1007/978-3-030-26710-0_103

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-26709-4

  • Online ISBN: 978-3-030-26710-0

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