Abstract
Despite the recent developments of OCT in neuro-ophthalmology, its use for diagnosing and monitoring nutritional and toxic optic neuropathies is still limited, due to the lack of powered, longitudinal studies. Small series have suggested that OCT may be useful in various toxic optic neuropathies in the acute stage, disclosing subtle retinal nerve fibre layer thickening, ophthalmoscopically undetectable. At later stages, retinal nerve fibre layer thinning affects the papillomacular bundle, and then, all quadrants, but only rarely before visual loss. Macular volume OCT studies have suggested that in toxic optic neuropathies, the primary site of injury may involve the retinal ganglion cells layers. Retinal nerve fibre layer thinning in the nasal quadrant in patients treated with vigabatrin appears to be predictive of visual field constriction.
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References
Grzybowski A, Zulsdorff M, Wilhelm H, Tonagel F. Toxic optic neuropathies: an updated review. Acta Ophthalmol. 2015;93:402–10. https://doi.org/10.1111/aos.12515.
Wang MY, Sadun AA. Drug-related mitochondrial optic neuropathies. J Neuroophthalmol. 2013;33:172–8.
Zoumalan CI, Agarwal M, Sadun AA. Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2005;243:410–6.
Sihota R, Sony P, Gupta V, et al. Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage. Invest Ophthalmol Vis Sci. 2006;47:2006–10.
Rebolleda G, Noval S, Contreras I, et al. Optic disc cupping after optic neuritis evaluated with optic coherence tomography. Eye (Lond). 2008;23:890–4.
Medeiros FA, Moura FC, Vessani RM, Susanna R. Axonal loss after traumatic optic neuropathy documented by optical coherence tomography. Am J Ophthalmol. 2003;135:406–8.
Fisher JB, Jacobs DA, Markowitz CF, et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology. 2006;113:324–32.
Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol’s antimicrobial action and implications for ethambutol-induced optic neuropathy. Mycobacteriology. 1998;30:83–7.
Masvidal D, Parrish RK II, Lam BL. Structural-functional dissociation in presumed ethambutol optic neuropathy. J Neuroophthalmol. 2010;30:305–10.
Sadun AA, Wang MY. Ethambutol optic neuropathy: how we can prevent 100,000 new cases of blindness each year. J Neuroophthalmol. 2008;28:265–8.
Sivakumaran P, Harrisson AC, Marschner J. Ocular toxicity from ethambutol: a review of four cases and recommended precautions. N Z Med J. 1998;13:428–30.
Kinoshita J, Iwata N, Maejima T, Kimotsuki T, Yasuda M. Retinal function and morphology in monkeys with ethambutol-induced optic neuropathy. Invest Ophthalmol Vis Sci. 2012;53:7052–62.
Chai SJ, Foroozan R. Decreased retinal nerve fibre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Br J Ophthalmol. 2007;91:895–7.
Kim U, Hwang JM. Early stage ethambutol optic neuropathy: retinal nerve fiber layer and optical coherence tomography. Eur J Ophthalmol. 2009;19:466–9.
Han J, Byun MK, Lee J, Han SY, Lee JB, Han SH. Longitudinal analysis of retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in ethambutol-induced optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2015;253:2293–9.
Vieira LM, Silva NF, et al. Retinal ganglion cell layer analysis by optical coherence tomography in toxic and nutritional optic neuropathy. J Neuroophthalmol. 2015;35(3):242–5.
Lee JY, Choi JH, Park KA, Oh SY. Ganglion cell layer and inner plexiform layer as predictors of vision recovery in ethambutol-induced optic neuropathy: a longitudinal OCT analysis. Invest Ophthalmol Vis Sci. 2018;59:2104–9.
Kim KL, Park SP. Visual function test for early detection of ethambutol induced ocular toxicity at the subclinical level. Cutan Ocul Toxicol. 2016;35:228–32.
Makino S. Utility of optical coherence tomography in the evaluation of patients with ethambutol-induced optic neuropathy. Int J Ophthalmol Vis Sci. 2014;12(1).
Junli X, Qi D, Shuangqing W, Wenyan S, Shanping Z, Liangyu Z. Treatment of ethambutol-induced optic neuropathy by buqihuoxue formula combined with methycobal. Int J Clin Exp Med. 2017;10:7100–15.
Fanta H, Mayer-Obcrditsch L. Ein Bcitrag zur Pathologie im Schncrven bci Methylalkoholvergiftung (Tierversuche). Klin Monatsbl Augenheilkd. 1953;122:288–394.
Sanaei-zadeh H, Zamani N, Shadnia SH. Outcomes of visual disturbances after methanol poisoning. Clin Toxicol (Phila). 2011;49:102–7.
Brent J, McMartin K, Phillips S, Aaron C, Kulig K. Fomepizole for the treatment of methanol poisoning. N Engl J Med. 2001;344:424–9.
Pakravan M, Sanjari N. Erythropoietin treatment for methanol optic neuropathy. J Neuroophthalmol. 2012;32:325–8.
Fujihara M, Kikuchi M, Kurimoto Y. Methanol-induced retinal toxicity patient examined by optical coherence tomography. Jpn J Ophthalmol. 2006;50:239–41.
Klein KA, Warren AK, Baumal CR, Hedges TR III. Optical coherence tomography findings in methanol toxicity. Int J Retina Vitreous. 2017;3:36.
Nurieva O, Diblik P, Kuthan P, Sklenka P, Meliska M, Bydzovsky J, Heissigerova J, Urban P, Kotikova K, Navratil T, Komarc M, Seidl Z, Vaneckova M, Pelclova D, Zakharov S. Progressive chronic retinal axonal loss following acute methanol-induced optic neuropathy: four-year prospective cohort study. Am J Ophthalmol. 2018;191:100–15.
Cullom ME, Heher KL, Miller NR, Savino PJ, Johns DR. Leber’s hereditary optic neuropathy masquerading as tobacco-alcohol amblyopia. Arch Ophthalmol. 1993;111:1482–5.
Mackey D, Howell N. Tobacco amblyopia. Am J Ophthalmol. 1994;117:817–9.
Johns DR, Heher KL, Miller NR, Smith KH. Leber’s hereditary optic neuropathy. Clinical manifestations of the 14484 mutation. Arch Ophthalmol. 1993;111:495–8.
Freeman AG. Optic neuropathy and chronic cyanide intoxication: a review. J R Soc Med. 1988;81:103–6.
Grzybowski A, Holder GE. Tobacco optic neuropathy (TON) - the historical and present concept of the disease. Acta Ophthalmol. 2011;89:495–9.
Behbehani R, Sergott RC, Savino PJ. Tobacco-alcohol amblyopia: a maculopathy? Br J Ophthalmol. 2005;89:1543–4.
Kee C, Hwang J-M. Optical coherence tomography in a patient with tobacco-alcohol amblyopia. Eye (Lond). 2008;22:469–70.
Moura FC, Monteiro ML. Evaluation of retinal nerve fiber layer thickness measurements using optical coherence tomography in patients with tobacco-alcohol-induced toxic optic neuropathy. Indian J Ophthalmol. 2010;58:143–6.
Grzybowski A. Tobacco amblyopia: does it really exist? Eye (Lond). 2007;21:1448–9.
Grzybowski A, Pieniazek M. Tobacco-alcohol amblyopia: nonexistent entity. Ind Psychiatry J. 2012;21:79.
Grzybowski A, Pieniążek M. Tobacco-alcohol amblyopia does not exist. Acta Ophthalmol. 2014;92:e77–8.
Grzybowski A. Mitochondrial optic neuropathies: additional facts and concepts. Clin Exp Ophthalmol. 2013; https://doi.org/10.1111/ceo.
Grzybowski A, Pieniazek M. Tobacco-alcohol amblyopia—nonexistent entity cannot be diagnosed. J Neurol Sci. 2013;332:156.
Macaluso DC, Shults WT, Fraunfelder FT. Features of amiodarone-induced optic neuropathy. Am J Ophthalmol. 1999;127:610–2.
Martínez-López-Portillo A, Martínez-Gamero BO, Mohamed-Noriega J, Cavazos-Adame H, Mohamed-Hamsho J. Behaviour of disc oedema during and after amiodarone optic neuropathy: case report. J Clin Diagn Res. 2014;8:VD04–5.
Pilania RK, Arora A, Agarwal A, Jindal AK, Aggarwal K, Krishnan G, Suri D, Gupta A, Singh S, Gupta V. Linezolid-induced mitochondrial toxicity presenting as retinal nerve fiber layer microcysts and optic and peripheral neuropathy in a patient with chronic granulomatous disease. Retin Cases Brief Rep. 2018;25 https://doi.org/10.1097/ICB.0000000000000777.
Ishii N, Kinouchi R, Inoue M, Yoshida A. Linezolid-induced optic neuropathy with a rare pathological change in the inner retina. Int Ophthalmol. 2016;36:761–6.
David JM, Anupriya A, Sheeja SJ. Presumed chemotherapy-induced optic neuropathy and maculopathy: a case report. Open Ophthalmol J. 2017;11:298–304.
Orssaud C, Roche O, Dufier JL. Nutritional optic neuropathies. J Neurol Sci. 2007;262:158–64.
Sawicka-Pierko A, Obuchowska I, Hady RH, Mariak Z, Dadan J. Nutritional optic neuropathy following bariatric surgery. Wideochir Inne Tech Maloinwazyjne. 2014;9(4):662–6.
Becker M, Masterson K, Delavelle J, Viallon M, Vargas ML, Becker CD. Imaging of the optic nerve. Eur J Radiol. 2010;74:299–313.
Gratton SM, Lam BL. Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency. Clin Ophthalmol. 2014;8:1021–4.
Pineles SL. Combined optic neuropathy and myelopathy secondary to copper deficiency. Surv Ophthalmol. 2010;55:386–92.
Naismith RT, Shepherd JB, Weihl CC, Tutlam NT, Cross AH. Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol. 2009;66:1025–7.
Spinazzi M, De Lazzari F, Tavolato B, Angelini C, Manara R, Armani M. Myelo-opticoneuropathy in copper deficiency occurring after partial gastrectomy: do small bowel bacterial overgrowth syndrome and occult zinc ingestion tip the balance? J Neurol. 2007;254:1012–7.
Woon C, Tang RA, Pardo G. Nutrition and optic nerve disease. Semin Ophthalmol. 1995;10:195–202.
Ahuja S, Kumar PS, Kumar VP, Kattimani S, Akkilagunta S. Effect of chronic alcohol and tobacco use on retinal nerve fiber layer thickness: a case-control study. BMJ Open Ophthalmol. 2016;1:e000003. https://doi.org/10.1136/bmjophth-2016-000003.
Rapoprt Y, Lavin PJM. Nutritional optic neuropathy caused by copper deficiency after bariatric surgery. J Neuroophthalmol. 2016;36:178–81.
Eke T, Talbot JF, Lawden MC. Severe persistent visual field constriction associated with vigabatrin. BMJ. 1997;314:180–1.
Daneshvar H, Racette L, Coupland SG, Kertes PJ, Guberman A, Zackon D. Symptomatic and asymptomatic visual loss in patients taking vigabatrin. Ophthalmology. 1999;106:1792–8.
Lawden MC, Eke T, Degg C, Harding GF, Wild JM. Visual field defects associated with vigabatrin therapy. J Neurol Neurosurg Psychiatry. 1999;67:716–22.
Miller NR, Johnson MA, Paul SR, Girkin CA, Perry JD, Endres M, et al. Visual dysfunction in patients receiving vigabatrin: clinical and electrophysiologic findings. Neurology. 1999;53:2082–7.
Wild JM, Ahn HS, Baulac M, Bursztyn J, Chiron C, Gandolfo E, et al. Vigabatrin and epilepsy: lessons learned. Epilepsia. 2007;48:1318–27.
Versino M, Veggiotti P. Reversibility of vigabratin-induced visual-field defect. Lancet. 1999;354:486.
Frisen L, Malmgrcn K. Characterization of vigabatrin-associated optic atrophy. Acta Ophthalmol Scand. 2003;81:466–73.
Iorga RE, Moraru A, Ozturk MR, Costin D. The role of optical coherence tomography in optic neuropathies. Rom J Ophthalmol. 2018;62:3–14.
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Grzybowski, A., Obuchowska, I., Arndt, C. (2020). OCT in Toxic and Nutritional Optic Neuropathies. In: Grzybowski, A., Barboni, P. (eds) OCT and Imaging in Central Nervous System Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-26269-3_18
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