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Gender Disparities in Liver Transplantation

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Abstract

Health disparities between men and women have become apparent in recent years in many fields, including the transplant setting. In this chapter, we address gender inequities in liver transplantation, including the type of liver diseases that leads to the need of transplantation, the referral pattern to transplant centers, access to waiting lists, and transplantation itself as well as posttransplant outcome. An analysis and literature search that integrates sociocultural, biological, and physiopathological perspectives is included in each of these different steps. Furthermore, recommendations regarding specific strategies that can be developed to reduce gender disparities in liver transplant care are also suggested. Particularly, changes in the liver allocation system and a consideration for a greater use of live donors and split livers are potential means to improving access to liver transplantation for women.

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References

  1. Gahagan J, Gray K, Whynacht A. Sex and gender matter in health research: addressing health inequities in health research reporting. Int J Equity Health. 2015;14:12.

    Article  Google Scholar 

  2. Miller VM. In pursuit of scientific excellence: sex matters. Am J Physiol Lung Cell Mol Physiol. 2012;302:L801–2.

    Article  CAS  Google Scholar 

  3. Melk A, Babitsch B, Borchert-Mörlins B, et al. Equally interchangeable? - how sex and gender affect transplantation. Transplantation. 2019;103(6):1094–110.

    Article  Google Scholar 

  4. Durazzo M, Belci P, Collo A, et al. Gender specific medicine in liver diseases: a point of view. World J Gastroenterol. 2014;20:2127–35.

    Article  Google Scholar 

  5. Nagoshi S. Sex- or gender-specific medicine in hepatology. Hepatol Res. 2008;38:219–24.

    Article  Google Scholar 

  6. Lelbach WK. Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann N Y Acad Sci. 1975;252:85–105.

    Article  CAS  Google Scholar 

  7. JK N, S O, Bergmann OM, et al. Lifetime drinking history in patients with alcoholic liver disease and patients with alcohol use disorder without liver disease. Scand J Gastroenterol. 2017;52:762–7.

    Article  Google Scholar 

  8. Bhala N, Cézard G, Ward HJ, et al. Ethnic variations in liver- and alcohol-related disease hospitalisations and mortality: the Scottish Health and Ethnicity Linkage Study. Alcohol Alcohol. 2016;51:593–601.

    Article  Google Scholar 

  9. Frezza M, di Padova C, Pozzato G, et al. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med. 1990;322:95–9.

    Article  CAS  Google Scholar 

  10. Non-Alcoholic Fatty Liver Disease Study Group, Lonardo A, Bellentani S, et al. Epidemiological modifiers of non-alcoholic fatty liver disease: focus on high-risk groups. Dig Liver Dis. 2015;47:997–1006.

    Article  Google Scholar 

  11. Fadini GP, de Kreutzenberg S, Albiero M, et al. Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens. Arterioscler Thromb Vasc Biol. 2008;28:997–1004.

    Article  CAS  Google Scholar 

  12. Carulli L, Lonardo A, Lombardini S, et al. Gender, fatty liver and GGT. Hepatology. 2006;44:278–9.

    Article  Google Scholar 

  13. Turola E, Petta S, Vanni E, et al. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis. Dis Model Mech. 2015;8:1037–46.

    Article  CAS  Google Scholar 

  14. Bruno S, Maisonneuve P, Castellana P, et al. Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial. BMJ. 2005;330:932.

    Article  Google Scholar 

  15. Clark JM, Brancati FL, Diehl AM. Nonalcoholic fatty liver disease. Gastroenterology. 2002;122:1649–57.

    Article  Google Scholar 

  16. Wang Z, Xu M, Hu Z, et al. Sex-specific prevalence of fatty liver disease and associated metabolic factors in Wuhan, south central China. Eur J Gastroenterol Hepatol. 2014;26:1015–21.

    Article  CAS  Google Scholar 

  17. Klair JS, Yang JD, Abdelmalek MF. A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease. Hepatology. 2016;64:85–91.

    Article  CAS  Google Scholar 

  18. Kurt Z, Barrere-Cain R, LaGuardia J, et al. Tissue-specific pathways and networks underlying sexual dimorphism in nonalcoholic fatty liver disease. Biol Sex Differ. 2018;9:46.

    Article  CAS  Google Scholar 

  19. Amadori A, Zamarchi R, De Silvestro G, et al. Genetic control of the CD4/CD8 cell ratio in humans. Nat Med. 1995;1:1279–83.

    Article  CAS  Google Scholar 

  20. Nalbandian G, Van de Water J, Gish R, et al. Is there a serological difference between men and women with primary biliary cirrhosis? Am J Gastroenterol. 1999;94:2482–6.

    Article  CAS  Google Scholar 

  21. Lucey MR, Neuberger JM, Williams R. Primary biliary cirrhosis in men. Gut. 1986;27:1373–6.

    Article  CAS  Google Scholar 

  22. Buchel E, Van Steenbergen W, Nevens F, Fevery J. Improvement of autoimmune hepatitis during pregnancy followed by flare-up after delivery. Am J Gastroenterol. 2002;97:3160–5.

    Article  Google Scholar 

  23. Villa E, Vukotic R, Cammà C, et al. Reproductive status is associated with the severity of fibrosis in women with hepatitis C. PLoS One. 2012;7(9):e44624.

    Article  CAS  Google Scholar 

  24. Grebely J, Bryant J, Hull P, et al. Factors associated with specialist assessment and treatment for hepatitis C virus infection in New South Wales, Australia. J Viral Hepat. 2011;18:e104–16.

    Article  CAS  Google Scholar 

  25. Agostini H, Castera L, Melin P, et al. HEPACOM: multicenter, observational prospective study of outcome and monitoring of HCV positive antiviral-naive patients managed in the French health care system. Gastroenterol Clin Biol. 2007;31:1074–80.

    Article  Google Scholar 

  26. Charlebois A, Lee L, Cooper E, et al. Factors associated with HCV antiviral treatment uptake among participants of a community-based HCV programme for marginalized patients. J Viral Hepat. 2012;19:836–42.

    Article  CAS  Google Scholar 

  27. Kanwal F, Kramer JR, El-Serag HB, et al. Race and gender differences in the use of direct acting antiviral agents for hepatitis C virus. Clin Infect Dis. 2016;63:291–9.

    Article  Google Scholar 

  28. Kramer JR, El-Serag H, Taylor TJ, et al. HCV-related complications are increasing in women veterans: a national cohort study. J Viral Hepat. 2017;24:955–65.

    Article  CAS  Google Scholar 

  29. Rademaker M. Do women have more adverse drug reactions? Am J Clin Dermatol. 2001;2:349–51.

    Article  CAS  Google Scholar 

  30. Ostapowicz G, Fontana RJ, Schiødt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–54.

    Article  Google Scholar 

  31. Mennecozzi M, Landesmann B, Palosaari T, et al. Sex differences in liver toxicity—do female and male human primary hepatocytes react differently to toxicants in vitro? PlosOne. 2015;10(4):e0122786.

    Article  Google Scholar 

  32. Schaubel DE, Stewart DE, Morrison HI, et al. Sex inequality in kidney transplantation rates. Arch Intern Med. 2000;160:2349–54.

    Article  CAS  Google Scholar 

  33. Bloembergen WE, Mauger EA, Wolfe RA, et al. Association of gender and access to cadaveric renal transplantation. Am J Kidney Dis. 1997;30:733–8.

    Article  CAS  Google Scholar 

  34. Thamer M, Hwang W, Fink NE, et al. U.S. nephrologists’ attitudes towards renal transplantation: results from a national survey. Transplantation. 2001;71:281–8.

    Article  CAS  Google Scholar 

  35. Kucirka LM, Grams ME, Balhara KS, et al. Disparities in provision of transplant information affect access to kidney transplantation. Am J Transplant. 2012;12:351–7.

    Article  CAS  Google Scholar 

  36. Bryce CL, Chang C, Angus DC, et al. The effect of race, sex, and insurance status on time-to-listing decisions for liver transplantation. J Tranplant. 2010;2010:467976.

    Google Scholar 

  37. Mathur AK, Ashby VB, Fuller DS, et al. Variation in access to the liver transplant waiting list in the United States. Transplantation. 2014;98:94–9.

    Article  Google Scholar 

  38. Oloruntoba O, Moylan CA. Gender-based disparities in access to and outcomes of liver transplantation. World J Hepatol. 2015 March 27;7(3):460–7.

    Article  Google Scholar 

  39. Moylan CA, Brady CW, Johnson JL, et al. Disparities in liver transplantation before and after introduction of the MELD score. JAMA. 2008;300:2371–8.

    Article  CAS  Google Scholar 

  40. Mathur AK, Schaubel DE, Gong Q, et al. Sex-based disparities in liver transplant rates in the United States. Am J Transplant. 2011;11:1435–43.

    Article  CAS  Google Scholar 

  41. Cholongitas E, Marelli L, Kerry A, et al. Female liver transplant recipients with the same GFR as male recipients have lower MELD scores—a systematic bias. Am J Transplant. 2007;7:685–92.

    Article  CAS  Google Scholar 

  42. Meyers RP, Shaheen AA, Aspinall AI, et al. Gender, renal function, and outcomes on the liver transplant waiting list: assessment of revised MELD including estimated glomerular filtration rate. J Hepatol. 2011;54:462–70.

    Article  Google Scholar 

  43. Lai JC, Terrault NA, Vittinghoff E, et al. Height contributes to the gender difference in wait-list mortality under the MELD-based liver allocation system. Am J Transplant. 2010;10:2658–64.

    Article  CAS  Google Scholar 

  44. Nephew LD, Goldberg DS, Lewis JD, et al. Exception points and body size contribute to gender disparity in liver transplantation. Clin Gastroenterol Hepatol. 2017;15:1286–93.

    Article  Google Scholar 

  45. Mindikoglu AL, Emre SH, Magder LS. Impact of estimated liver volume and liver weight on gender disparity in liver transplantation. Liver Transpl. 2013;19:89–95.

    Article  Google Scholar 

  46. Cullaro G, Sarkar M, Lai JC. Sex-based disparities in delisting for being “too sick” for liver transplantation. Am J Transplant. 2018;18:1214–9.

    Article  CAS  Google Scholar 

  47. Allen AM, Heimbach JK, Larson JJ, et al. Reduced access to liver transplantation in women: role of height, MELD exception scores, and renal function underestimation. Transplantation. 2018;102:1710–6.

    Article  Google Scholar 

  48. Bruns H, Lozanovski VJ, Schultze D, et al. Prediction of postoperative mortality in liver transplantation in the era of MELD-based liver allocation: a multivariate analysis. PLoS One. 2014;9(6):e98782.

    Article  Google Scholar 

  49. Thuluvath PJ, Guidinger MK, Fung JJ, et al. Liver transplantation in the United States, 1999-2008. Am J Transplant. 2010;10:1003–19.

    Article  CAS  Google Scholar 

  50. Sarkar M, Watt KD, Terrault N, Berenguer M. Outcomes in liver transplantation: does sex matter? J Hepatol. 2015;62:946–55.

    Article  Google Scholar 

  51. Mathur AK, Schaubel DE, Zhang H, al e. Disparities in liver transplantation: the association between donor quality and recipient race/ethnicity and sex. Transplantation. 2014;97:862–9.

    Article  Google Scholar 

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Correspondence to Marina Berenguer .

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Serrano, T., Berenguer, M. (2020). Gender Disparities in Liver Transplantation. In: Rahimi, R. (eds) The Critically Ill Cirrhotic Patient. Springer, Cham. https://doi.org/10.1007/978-3-030-24490-3_15

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  • DOI: https://doi.org/10.1007/978-3-030-24490-3_15

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