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The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases pp 77–88Cite as

Aspects of Prostaglandin Glycerol Ester Biology

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1161))

Abstract

The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins. However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG). The products of 2-AG oxygenation, prostaglandin glycerol esters (PG-Gs), are analogous to canonical prostaglandins. This chapter reviews the literature detailing the production, metabolism, and bioactivity of these compounds, as well as their detection in intact animals.

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Acknowledgments

This work was supported by CA89450, GM15431 and (cite Sachin’s grant(s)).

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Authors and Affiliations

  1. A. B. Hancock Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA

    Philip J. Kingsley & Lawrence J. Marnett

  2. A. B. Hancock Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Carol A. Rouzer & Amanda J. Morgan

  3. Department of Psychiatry and Behavioral Sciences, Department of Molecular Physiology & Biophysics, and the Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA

    Sachin Patel

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  1. Philip J. Kingsley
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  2. Carol A. Rouzer
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  4. Sachin Patel
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  5. Lawrence J. Marnett
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Correspondence to Lawrence J. Marnett .

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Editors and Affiliations

  1. 431 Chemistry Building, Wayne State University, Detroit, MI, USA

    Kenneth V. Honn

  2. National Institutes of Health, Durham, NC, USA

    Darryl C. Zeldin

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Kingsley, P.J., Rouzer, C.A., Morgan, A.J., Patel, S., Marnett, L.J. (2019). Aspects of Prostaglandin Glycerol Ester Biology. In: Honn, K., Zeldin, D. (eds) The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases. Advances in Experimental Medicine and Biology, vol 1161. Springer, Cham. https://doi.org/10.1007/978-3-030-21735-8_8

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