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Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

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Academic Pain Medicine

Abstract

Nonsteroidal anti-inflammatory drugs, NSAIDs, have a substantial role in medical practice. They are commonly acquired as over-the-counter medications but may also be prescribed for their ability to relieve pain, alleviate inflammation, and reduce fever. NSAIDs work by inhibition of the cyclooxygenase enzymes (COX), affecting the production of mediators involved in pain pathways and inflammation. NSAIDs have become well known for a multitude of adverse effects, which stem from altering the homeostatic properties of cyclooxygenase in various organs. In an attempt to mitigate some of the adverse effects, COX-2 selective medications were introduced; however, there still remain undesired reactions and potential harm from their use.

Note: Although acetaminophen is not an NSAID, it is typically discussed alongside these compounds. In this text, acetaminophen is covered in the Cancer Pain chapter.

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Change history

  • 27 March 2021

    The book was inadvertently published with incorrect authorships in Chapters 13, 14 and 47. It has been updated along with corresponding affiliation information as follows: Chapter 13:

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Author information

Authors and Affiliations

  1. Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA

    Ricardo Maturana & Andrew So

  2. Department of Anesthesiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA

    Karina Gritsenko

Authors
  1. Ricardo Maturana
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  2. Andrew So
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  3. Karina Gritsenko
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Corresponding author

Correspondence to Karina Gritsenko .

Editor information

Editors and Affiliations

  1. Pain Medicine Fellowship, Department of Anesthesiology, Perioperative and Pain Medicine, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Yury Khelemsky

  2. Pain Medicine Fellowship, Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Anuj Malhotra

  3. Regional Anesthesia and Acute Pain Medicine Fellowship, Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA

    Karina Gritsenko

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Maturana, R., So, A., Gritsenko, K. (2019). Nonsteroidal Anti-inflammatory Drugs (NSAIDs). In: Khelemsky, Y., Malhotra, A., Gritsenko, K. (eds) Academic Pain Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-18005-8_13

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  • DOI: https://doi.org/10.1007/978-3-030-18005-8_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-18004-1

  • Online ISBN: 978-3-030-18005-8

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