Abstract
It is a large deciduous twining shrub, found in South Asia and Australia. In Ayurveda, seeds are classified as Medhya Rasayana (nervine tonic) and credited with stimulating intellectual powers and sharpening memory, thence called Jyotishmati . Its therapeutic uses include vãtavyãdhi, smrtidaurbalya, and śvitra. The seed oil was used by courts and colleges of India and by a great many pundits to increase intelligence of their pupils. Seed oil has also been used in Ayurveda for treatment of intestinal disorders. Muslim practitioners of Unani medicine describe them as aphrodisiac and stimulating. Seed decoction, with or without aromatics, is used in the treatment of rheumatism, gout, paralysis and leprosy; the seed oil is rubefacient and applied to relieve rheumatic pains. Methanol leaf extract tested positive for steroid, terpenoid, carbohydrate, alkaloid, saponin, and phenolic compounds, and several sesquiterpenes have been isolated from seeds. Aqueous seed extract is neuroprotective against oxidative stress due to free radical damage, and protects neuronal cells against glutamate-toxicity, exhibits cognition-enhancing and antioxidant properties, and cholinergic activity, which might be involved in improving memory performance. There are no clinical studies reported in mainstream literature.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Ahmad F, Khan RA, Rasheed S. Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. J Ethnopharmacol. 1994;42:193–8.
Bhagya V, Christofer T, Shankaranarayana Rao BS. Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment. Indian J Pharmacol. 2016;48:687–93.
Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G. Nootropic activity of Celastrus paniculatus seed. Pharm Biol. 2010;48:324–7.
Bidwai PP, Wangoo D, Bhullar N. Antispermatogenic action of Celastrus paniculatus seed extract in the rat with reversible changes in the liver. J Ethnopharmacol. 1990;28:293–303.
Borbone N, Borrelli F, Montesano D, et al. Identification of a new sesquiterpene polyol ester from Celastrus paniculatus. Planta Med. 2007;73:792–4.
Borrelli F, Borbone N, Capasso R, et al. New sesquiterpenes with intestinal relaxant effect from Celastrus paniculatus. Planta Med. 2004;70:652–6.
Borrelli F, Borbone N, Capasso R, et al. Potent relaxant effect of a Celastrus paniculatus extract in the rat and human ileum. J Ethnopharmacol. 2009;122:434–8.
Casey RC. 298 alleged antifertility plants of India. Indian J Med Sci. 1960;14:590–600.
Chakrabarty M, Bhat P, Kumari S, et al. Corticohippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: neurobehavioural, biochemical, histological study. J Pharmacol Pharmacother. 2012;3:161–71.
Debnath M, Biswas M, Shukla VJ, Nishteswar K. Phytochemical and analytical evaluation of Jyotishmati (Celastrus paniculatus Willd.) leaf extracts. Ayu. 2014;35:54–7.
Gattu M, Boss KL, Terry AV Jr, Buccafusco JJ. Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacol Biochem Behav. 1997;57:793–9.
Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide-induced oxidative injury. Fitoterapia. 2003;74:658–69.
Godkar PB, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain. J Ethnopharmacol. 2004;93:213–9.
Godkar PB, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells. Phytomedicine. 2006;13:29–36.
Jyothi KS, Seshagiri M. In-vitro activity of saponins of Bauhinia purpurea, Madhuca longifolia, Celastrus paniculatus and Semecarpus anacardium on selected oral pathogens. J Dent (Tehran). 2012;9:216–23.
Kulkarni YA, Agarwal S, Garud MS. Effect of Jyotishmati (Celastrus paniculatus) seeds in animal models of pain and inflammation. J Ayurveda Integr Med. 2015;6:82–8.
Kumar MH, Gupta YK. Antioxidant property of Celastrus paniculatus Willd.: a possible mechanism in enhancing cognition. Phytomedicine. 2002;9:302–11.
Lekha G, Mohan K, Samy IA. Effect of Celastrus paniculatus seed oil (Jyothismati oil) on acute and chronic immobilization stress induced in swiss albino mice. Pharmacognosy Res. 2010;2:169–74.
Malhi BS, Trivedi VP. Vegetable antifertility drugs of India. Quart J Crude Drug Res. 1972;12:1922.
Malik J, Karan M, Dogra R. Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism. Pharm Biol. 2017;55:980–90.
Nalini K, Karanth KS, Rao A, Aroor AR. Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. J Ethnopharmacol. 1995;47:101–8.
Palle S, Kanakalatha A, Kavitha CN. Gastroprotective and antiulcer effects of Celastrus paniculatus seed oil against several gastric ulcer models in rats. J Diet Suppl. 2018;15:373–85.
Patil RH, Prakash K, Maheshwari VL. Hypolipidemic effect of Celastrus paniculatus in experimentally induced hypercholesterolemic Wistar rats. Indian J Clin Biochem. 2010;25:405–10.
Rajkumar R, Kumar EP, Sudha S, Suresh B. Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour. Fitoterapia. 2007;78:120–4.
Raut SB, Parekar RR, Jadhav KS, Marathe PA, Rege NN. Effect of Jyotiṣmatī seed oil on spatial and fear memory using scopolamine induced amnesia in mice. Anc Sci Life. 2015;34:130–3.
Russo A, Izzo AA, Cardile V, Borrelli F, Vanella A. Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomedicine. 2001;8:125–32.
Saha JC, Savini EC, Kasinathan S. Ecbolic properties of Indian medicinal plants. I. Indian J Med Sci. 1961;49:130.
Valecha R, Dhingra D. Behavioral and biochemical evidences for antidepressant-like activity of Celastrus Paniculatus seed oil in mice. Basic Clin Neurosci. 2016;7:49–56.
Vonshak A, Barazani O, Sathiyamoorthy P, et al. Screening of South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytother Res. 2003;17:1123–5.
Weng JR, Yen MH, Lin WY. Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells. Phytochemistry. 2013;94:211–9.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Akbar, S. (2020). Celastrus paniculatus Willd. (Celastraceae). In: Handbook of 200 Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-16807-0_59
Download citation
DOI: https://doi.org/10.1007/978-3-030-16807-0_59
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-16806-3
Online ISBN: 978-3-030-16807-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)