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Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders pp 243–258Cite as

PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism

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Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1134))

Abstract

Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.

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Authors and Affiliations

  1. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA

    Liwei Lang & Yong Teng

  2. Department of Biology, College of Science and Mathematics, Augusta University, Augusta, GA, USA

    Ron Chemmalakuzhy

  3. The Robinson College of Business, Georgia State University, Atlanta, GA, USA

    Chloe Shay

  4. Division of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA

    Chloe Shay

  5. Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA

    Yong Teng

  6. Department of Medical Laboratory, Imaging and Radiologic Sciences, College of Allied Health, Augusta University, Augusta, GA, USA

    Yong Teng

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  1. Liwei Lang
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  2. Ron Chemmalakuzhy
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  3. Chloe Shay
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  4. Yong Teng
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Correspondence to Yong Teng .

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Editors and Affiliations

  1. Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Lang, L., Chemmalakuzhy, R., Shay, C., Teng, Y. (2019). PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism. In: Guest, P. (eds) Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1134. Springer, Cham. https://doi.org/10.1007/978-3-030-12668-1_13

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