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Cellular Injury Biomechanics of Central Nervous System Trauma

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Trauma Biomechanics

Abstract

Traumatic brain injury (TBI) remains a significant source of mortality and morbidity throughout the world, in part because of the complex mechanisms. The complexity arises not only from the complicated intracranial biomechanics, but because that mechanical stimulus is only the start of a series of biological responses that unfold over minutes to days after the event. In this chapter, co-authors Nevin Varghese and Barclay Morrison explore the effect on cells of the primary injury that occurs during the mechanical event and the ensuing biological mechanisms of the secondary injury process.

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Authors and Affiliations

  1. AGU Zürich, Zürich, Switzerland

    Kai-Uwe Schmitt

  2. Zürich, Switzerland

    Peter F. Niederer

  3. University of Waterloo, Waterloo, ON, Canada

    Duane S. Cronin

  4. Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY, USA

    Barclay Morrison III

  5. AGU Zürich, Zürich, Switzerland

    Markus H. Muser

  6. Uitikon Waldegg, Switzerland

    Felix Walz

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  1. Kai-Uwe Schmitt
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  2. Peter F. Niederer
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  3. Duane S. Cronin
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  4. Barclay Morrison III
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  5. Markus H. Muser
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  6. Felix Walz
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Schmitt, KU., Niederer, P.F., Cronin, D.S., Morrison III, B., Muser, M.H., Walz, F. (2019). Cellular Injury Biomechanics of Central Nervous System Trauma. In: Trauma Biomechanics. Springer, Cham. https://doi.org/10.1007/978-3-030-11659-0_3

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  • DOI: https://doi.org/10.1007/978-3-030-11659-0_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11658-3

  • Online ISBN: 978-3-030-11659-0

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