Abstract
A key feature that serves to control the behavior of the microcirculation is the state of cell activation (64). In healthy individuals without cardiovascular complications or risk factors, leukocytes, platelets, endothelial cells or mast cells are in a low state of activation. There are low numbers of leukocytes (neutrophils, monocytes, lymphocytes) adhering to microvascular endothelium, no platelet adhesion or aggregation, and the endothelial permeability is low. The arterioles exhibit strong autoregulatory control, the capillary perfusion is extraordinarily stable and there is little evidence for blood cell swelling or plasma coagulation. This is the state of the microcirculation without any complications.
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Schmid-Schönbein, G.W., Hugli, T.E., Mitsuoka, H., Kistler, E.B. (2003). Mechanisms for Microvascular Cell Activation: Pancreatic Digestive Enzyme Derived Inflammatory Mediators in Shock. In: Molecular Basis for Microcirculatory Disorders. Springer, Paris. https://doi.org/10.1007/978-2-8178-0761-4_12
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