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Respiratory Diseases in Obesity

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Part of the book series: Nutrition and Health ((NH))

Abstract

While it has long been recognized that obesity is a risk factor for diseases such as type II diabetes and steatohepatitis, it has only recently been appreciated that obesity is a major risk factor for lung diseases such as asthma, sleep apnea and likely also pulmonary hypertension. Obesity also dramatically alters the clinical course of other common lung diseases such as chronic obstructive pulmonary disease and acute lung injury. The purpose of this chapter will be first to review the effects of obesity on lung function, and then to discuss the effect of obesity on the aforementioned pulmonary diseases.

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References

  1. Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ. Effects of mass loading the respiratory system in man. J Appl Physiol. 1964;19:959–66.

    CAS  PubMed  Google Scholar 

  2. Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ. The total work of breathing in normal and obese men. J Clin Invest. 1964;43:728–39.

    CAS  PubMed Central  PubMed  Google Scholar 

  3. Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest. 2006;130:827–33.

    PubMed  Google Scholar 

  4. Collins LC, Hoberty PD, Walker JF, Fletcher EC, Peiris AN. The effect of body fat distribution on pulmonary function tests. Chest. 1995;107:1298–302.

    CAS  PubMed  Google Scholar 

  5. Nicolacakis K, Skowronski ME, Coreno AJ, West E, Nader NZ, Smith RL, McFadden Jr ER. Observations on the physiological interactions between obesity and asthma. J Appl Physiol. 2008;105:1533–41.

    PubMed Central  PubMed  Google Scholar 

  6. King GG, Brown NJ, Diba C, Thorpe CW, Munoz P, Marks GB, Toelle B, Ng K, Berend N, Salome CM. The effects of body weight on airway calibre. Eur Respir J. 2005;25:896–901.

    CAS  PubMed  Google Scholar 

  7. Watson RA, Pride NB. Postural changes in lung volumes and respiratory resistance in subjects with obesity. J Appl Physiol. 2005;98:512–7.

    CAS  PubMed  Google Scholar 

  8. Hedenstierna G, Santesson J, Norlander O. Airway closure and distribution of inspired gas in the extremely obese, breathing spontaneously and during anaesthesia with intermittent positive pressure ventilation. Acta Anaesthesiol Scand. 1976;20:334–42.

    CAS  PubMed  Google Scholar 

  9. Hakala K, Mustajoki P, Aittomaki J, Sovijarvi AR. Effect of weight loss and body position on pulmonary function and gas exchange abnormalities in morbid obesity. Int J Obes Relat Metab Disord. 1995;19:343–6.

    CAS  PubMed  Google Scholar 

  10. Chapman DG, Berend N, King GG, Salome CM. Increased airway closure is a determinant of airway hyperresponsiveness. Eur Respir J. 2008;32:1563–9.

    CAS  PubMed  Google Scholar 

  11. Yoo Y, Yu J, Lee SH, Kim do K, Choi SH, Kim CK, Koh YY. Comparison of delta fvc (% decrease in fvc at the pc(20)) between cough-variant asthma and classic asthma. J Asthma. 2007;44:35–8.

    CAS  PubMed  Google Scholar 

  12. Schachter LM, Salome CM, Peat JK, Woolcock AJ. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax. 2001;56:4–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  13. Sin DD, Jones RL, Man SF. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med. 2002;162:1477–81.

    PubMed  Google Scholar 

  14. Ferretti A, Giampiccolo P, Cavalli A, Milic-Emili J, Tantucci C. Expiratory flow limitation and orthopnea in massively obese subjects. Chest. 2001;119:1401–8.

    CAS  PubMed  Google Scholar 

  15. Pankow W, Podszus T, Gutheil T, Penzel T, Peter J, Von Wichert P. Expiratory flow limitation and intrinsic positive end-expiratory pressure in obesity. J Appl Physiol. 1998;85:1236–43.

    CAS  PubMed  Google Scholar 

  16. Mahadev S, Farah CS, King GG, Salome CM. Obesity, expiratory flow limitation and asthma symptoms. Pulm Pharmacol Ther. 2013;26:438–43.

    Google Scholar 

  17. Dellaca RL, Duffy N, Pompilio PP, Aliverti A, Koulouris NG, Pedotti A, Calverley PM. Expiratory flow limitation detected by forced oscillation and negative expiratory pressure. Eur Respir J. 2007;29:363–74.

    CAS  PubMed  Google Scholar 

  18. Kajbaf TZ, Asar S, Alipoor MR. Relationship between obesity and asthma symptoms among children in ahvaz, iran: a cross sectional study. Ital J Pediatr. 2011;37:1.

    PubMed Central  PubMed  Google Scholar 

  19. Chu YT, Chen WY, Wang TN, Tseng HI, Wu JR, Ko YC. Extreme bmi predicts higher asthma prevalence and is associated with lung function impairment in school-aged children. Pediatr Pulmonol. 2009;44:472–9.

    PubMed  Google Scholar 

  20. Cassol VE, Rizzato TM, Teche SP, Basso DF, Centenaro DF, Maldonado M, Moraes EZ, Hirakata VN, Sole D, Menna-Barreto SS. Obesity and its relationship with asthma prevalence and severity in adolescents from southern brazil. J Asthma. 2006;43:57–60.

    PubMed  Google Scholar 

  21. Gennuso J, Epstein LH, Paluch RA, Cerny F. The relationship between asthma and obesity in urban minority children and adolescents. Arch Pediatr Adolesc Med. 1998;152:1197–200.

    CAS  PubMed  Google Scholar 

  22. Camargo Jr CA, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med. 1999;159:2582–8.

    PubMed  Google Scholar 

  23. Belle SH, Chapman W, Courcoulas AP, Flum DR, Gagner M, Inabnet WB, King WC, Mitchell JE, Patterson EJ, Thirlby R, et al. Relationship of body mass index with demographic and clinical characteristics in the longitudinal assessment of bariatric surgery (labs). Surg Obes Relat Dis. 2008;4:474–80.

    PubMed Central  PubMed  Google Scholar 

  24. Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007;175:661–6.

    PubMed Central  PubMed  Google Scholar 

  25. Aaron SD, Vandemheen KL, Boulet LP, McIvor RA, Fitzgerald JM, Hernandez P, Lemiere C, Sharma S, Field SK, Alvarez GG, et al. Overdiagnosis of asthma in obese and nonobese adults. CMAJ. 2008;179:1121–31.

    PubMed Central  PubMed  Google Scholar 

  26. Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest. 2006;130:890–5.

    PubMed  Google Scholar 

  27. Chen Y, Rennie D, Cormier Y, Dosman J. Atopy, obesity, and asthma in adults: the humboldt study. J Agromedicine. 2009;14:222–7.

    PubMed  Google Scholar 

  28. Holguin F, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, et al. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol. 2011;127:1486–93. e1482.

    PubMed Central  PubMed  Google Scholar 

  29. Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy JV. Cluster analysis of obesity and asthma phenotypes. PLoS One. 2012;7:e36631.

    CAS  PubMed Central  PubMed  Google Scholar 

  30. Quinto KB, Zuraw BL, Poon KY, Chen W, Schatz M, Christiansen SC. The association of obesity and asthma severity and control in children. J Allergy Clin Immunol. 2011;128:964–9.

    PubMed  Google Scholar 

  31. Taylor B, Mannino D, Brown C, Crocker D, Twum-Baah N, Holguin F. Body mass index and asthma severity in the national asthma survey. Thorax. 2008;63:14–20.

    CAS  PubMed  Google Scholar 

  32. Vortmann M, Eisner MD. Bmi and health status among adults with asthma. Obesity (Silver Spring). 2008;16:146–52.

    Google Scholar 

  33. Lessard A, Turcotte H, Cormier Y, Boulet LP. Obesity and asthma: a specific phenotype? Chest. 2008;134:317–23.

    PubMed  Google Scholar 

  34. Schatz M, Mosen DM, Kosinski M, Vollmer WM, Magid DJ, O'Connor E, Zeiger RS. Predictors of asthma control in a random sample of asthmatic patients. J Asthma. 2007;44:341–5.

    PubMed  Google Scholar 

  35. Lavoie KL, Bacon SL, Labrecque M, Cartier A, Ditto B. Higher bmi is associated with worse asthma control and quality of life but not asthma severity. Respir Med. 2006;100:648–57.

    PubMed  Google Scholar 

  36. Mosen DM, Schatz M, Magid DJ, Camargo Jr CA. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol. 2008;122:507–11. e506.

    PubMed  Google Scholar 

  37. Dixon AE, Pratley RE, Forgione PM, Kaminsky DA, Whittaker-Leclair LA, Griffes LA, Garudathri J, Raymond D, Poynter ME, Bunn JY, et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol. 2011;128:508–15. e501–502.

    PubMed Central  PubMed  Google Scholar 

  38. Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol. 2010;108:206–11.

    PubMed  Google Scholar 

  39. Ding DJ, Martin JG, Macklem PT. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol. 1987;62:1324–30.

    CAS  PubMed  Google Scholar 

  40. Skloot G, Permutt S, Togias A. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J Clin Invest. 1995;96:2393–403.

    CAS  PubMed Central  PubMed  Google Scholar 

  41. Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol. 2005;115:103–9.

    CAS  PubMed  Google Scholar 

  42. Shore SA, Terry RD, Flynt L, Xu A, Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol. 2006;118:389–95.

    CAS  PubMed  Google Scholar 

  43. Williams AS, Chen L, Kasahara DI, Si H, Wurmbrand AP, Shore SA. Obesity and airway responsiveness: role of TNFR2. Pulm Pharmacol Ther. 2013;26(4):444–54.

    Google Scholar 

  44. Lang JE, Williams ES, Mizgerd JP, Shore SA. Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. Am J Physiol Lung Cell Mol Physiol. 2008;294:L1013–20.

    CAS  PubMed  Google Scholar 

  45. Wood LG, Garg ML, Gibson PG. A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma. J Allergy Clin Immunol. 2011;127:1133–40.

    PubMed  Google Scholar 

  46. Teodorescu M, Consens FB, Bria WF, Coffey MJ, McMorris MS, Weatherwax KJ, Palmisano J, Senger CM, Ye Y, Kalbfleisch JD, et al. Predictors of habitual snoring and obstructive sleep apnea risk in patients with asthma. Chest. 2009;135:1125–32.

    PubMed  Google Scholar 

  47. Strine TW, Mokdad AH, Balluz LS, Gonzalez O, Crider R, Berry JT, Kroenke K. Depression and anxiety in the united states: findings from the 2006 behavioral risk factor surveillance system. Psychiatr Serv. 2008;59:1383–90.

    PubMed  Google Scholar 

  48. Strine TW, Ford ES, Balluz L, Chapman DP, Mokdad AH. Risk behaviors and health-related quality of life among adults with asthma: the role of mental health status. Chest. 2004;126:1849–54.

    PubMed  Google Scholar 

  49. Strine TW, Mokdad AH, Balluz LS, Berry JT, Gonzalez O. Impact of depression and anxiety on quality of life, health behaviors, and asthma control among adults in the united states with asthma, 2006. J Asthma. 2008;45:123–33.

    PubMed  Google Scholar 

  50. Eslick GD. Gastrointestinal symptoms and obesity: a meta-analysis. Obes Rev. 2012;13:469–79.

    CAS  PubMed  Google Scholar 

  51. Schan CA, Harding SM, Haile JM, Bradley LA, Richter JE. Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology. Chest. 1994;106:731–7.

    CAS  PubMed  Google Scholar 

  52. Harding SM. Gastroesophageal reflux and asthma: insight into the association. J Allergy Clin Immunol. 1999;104:251–9.

    CAS  PubMed  Google Scholar 

  53. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J. 2006;27:495–503.

    CAS  PubMed  Google Scholar 

  54. Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med. 2007;101:2240–7.

    PubMed  Google Scholar 

  55. Camargo Jr CA, Boulet LP, Sutherland ER, Busse WW, Yancey SW, Emmett AH, Ortega HG, Ferro TJ. Body mass index and response to asthma therapy: fluticasone propionate/salmeterol versus montelukast. J Asthma. 2010;47:76–82.

    CAS  PubMed  Google Scholar 

  56. Dixon AE, Shade DM, Cohen RI, Skloot GS, Holbrook JT, Smith LJ, Lima JJ, Allayee H, Irvin CG, Wise RA. Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma. 2006;43:553–8.

    PubMed  Google Scholar 

  57. Sutherland ER, Camargo Jr CA, Busse WW, Meltzer EO, Ortega HG, Yancey SW, Emmett AH, Stempel DA. Comparative effect of body mass index on response to asthma controller therapy. Allergy Asthma Proc. 2010;31:20–5.

    PubMed  Google Scholar 

  58. Farah CS, Kermode JA, Downie SR, Brown NJ, Hardaker KM, Berend N, King GG, Salome CM. Obesity is a determinant of asthma control independent of inflammation and lung mechanics. Chest. 2011;140:659–66.

    PubMed  Google Scholar 

  59. Scott HA, Gibson PG, Garg ML, Wood LG. Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J. 2011;38:594–602.

    CAS  PubMed  Google Scholar 

  60. Stenius-Aarniala B, Poussa T, Kvarnstrom J, Gronlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ. 2000;320:827–32.

    CAS  PubMed Central  PubMed  Google Scholar 

  61. Boulet LP, Turcotte H, Martin J, Poirier P. Effect of bariatric surgery on airway response and lung function in obese subjects with asthma. Respir Med. 2012;106(5):651–60.

    PubMed  Google Scholar 

  62. Soriano JB, Rodriguez-Roisin R. Chronic obstructive pulmonary disease overview: epidemiology, risk factors, and clinical presentation. Proc Am Thorac Soc. 2011;8:363–7.

    PubMed  Google Scholar 

  63. Steuten LM, Creutzberg EC, Vrijhoef HJ, Wouters EF. Copd as a multicomponent disease: inventory of dyspnoea, underweight, obesity and fat free mass depletion in primary care. Prim Care Respir J. 2006;15:84–91.

    PubMed  Google Scholar 

  64. Schols AM, Gosker HR. The pathophysiology of cachexia in chronic obstructive pulmonary disease. Curr Opin Support Palliat Care. 2009;3:282–7.

    PubMed  Google Scholar 

  65. Yang L, Zhou M, Smith M, Yang G, Peto R, Wang J, Boreham J, Hu Y, Chen Z. Body mass index and chronic obstructive pulmonary disease-related mortality: a nationally representative prospective study of 220,000 men in china. Int J Epidemiol. 2010;39:1027–36.

    PubMed  Google Scholar 

  66. Vozoris N, O'Donnell DE. Prevalence, risk factors, activity limitation and health care utilization of an obese, population-based sample with chronic obstructive pulmonary disease. Can Respir J. 2012;19:e18–24.

    PubMed Central  PubMed  Google Scholar 

  67. Monteiro F, Camillo CA, Vitorasso R, Sant’anna T, Hernandes NA, Probst VS, Pitta F. Obesity and physical activity in the daily life of patients with copd. Lung. 2012;190:403–10.

    PubMed  Google Scholar 

  68. Cecere LM, Littman AJ, Slatore CG, Udris EM, Bryson CL, Boyko EJ, Pierson DJ, Au DH. Obesity and copd: associated symptoms, health-related quality of life, and medication use. COPD. 2011;8:275–84.

    PubMed Central  PubMed  Google Scholar 

  69. Ora J, Laveneziana P, Ofir D, Deesomchok A, Webb KA, O’Donnell DE. Combined effects of obesity and chronic obstructive pulmonary disease on dyspnea and exercise tolerance. Am J Respir Crit Care Med. 2009;180:964–71.

    PubMed  Google Scholar 

  70. Ramachandran K, McCusker C, Connors M, Zuwallack R, Lahiri B. The influence of obesity on pulmonary rehabilitation outcomes in patients with copd. Chron Respir Dis. 2008;5:205–9.

    CAS  PubMed  Google Scholar 

  71. Poulain M, Doucet M, Drapeau V, Fournier G, Tremblay A, Poirier P, Maltais F. Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease. Chron Respir Dis. 2008;5:35–41.

    CAS  PubMed  Google Scholar 

  72. Watz H, Waschki B, Kirsten A, Muller KC, Kretschmar G, Meyer T, Holz O, Magnussen H. The metabolic syndrome in patients with chronic bronchitis and copd: frequency and associated consequences for systemic inflammation and physical inactivity. Chest. 2009;136:1039–46.

    CAS  PubMed  Google Scholar 

  73. Marquis K, Maltais F, Duguay V, Bezeau AM, LeBlanc P, Jobin J, Poirier P. The metabolic syndrome in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil. 2005;25:226–32. discussion 233–224.

    PubMed  Google Scholar 

  74. Drager LF, Jun JC, Polotsky VY. Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea. Best Pract Res Clin Endocrinol Metab. 2010;24:843–51.

    CAS  PubMed Central  PubMed  Google Scholar 

  75. Burger CD, Foreman AJ, Miller DP, Safford RE, McGoon MD, Badesch DB. Comparison of body habitus in patients with pulmonary arterial hypertension enrolled in the registry to evaluate early and long-term pah disease management with normative values from the national health and nutrition examination survey. Mayo Clin Proc. 2011;86:105–12.

    PubMed Central  PubMed  Google Scholar 

  76. Summer R, Walsh K, Medoff BD. Obesity and pulmonary arterial hypertension: is adiponectin the molecular link between these conditions? Pulm Circ. 2011;1:440–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  77. Barnett CF, De Marco T. Pulmonary hypertension associated with left-sided heart disease. Heart Fail Clin. 2012;8:447–59.

    PubMed  Google Scholar 

  78. Khan MF, Movahed MR. Obesity cardiomyopathy and systolic function: obesity is not independently associated with dilated cardiomyopathy. Heart Fail Rev. 2013;18:207–17.

    Google Scholar 

  79. Perez VA, Haddad F, Zamanian RT. Diagnosis and management of pulmonary hypertension associated with left ventricular diastolic dysfunction. Pulm Circ. 2012;2:163–9.

    PubMed Central  PubMed  Google Scholar 

  80. Golbin JM, Somers VK, Caples SM. Obstructive sleep apnea, cardiovascular disease, and pulmonary hypertension. Proc Am Thorac Soc. 2008;5:200–6.

    PubMed Central  PubMed  Google Scholar 

  81. Borel JC, Borel AL, Monneret D, Tamisier R, Levy P, Pepin JL. Obesity hypoventilation syndrome: from sleep-disordered breathing to systemic comorbidities and the need to offer combined treatment strategies. Respirology. 2012;17:601–10.

    PubMed  Google Scholar 

  82. Curley G, Laffey JG, Kavanagh BP. Bench-to-bedside review: carbon dioxide. Crit Care. 2010;14:220.

    PubMed Central  PubMed  Google Scholar 

  83. Singh A, Foster GD, Gunawardana J, McCoy TA, Nguyen T, Vander Veur S, Komaroff E, Rao AK. Elevated circulating tissue factor procoagulant activity, factor vii, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state. Br J Haematol. 2012;158:523–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  84. Allman-Farinelli MA. Obesity and venous thrombosis: a review. Semin Thromb Hemost. 2011;37:903–7.

    PubMed  Google Scholar 

  85. Shibuya N, Frost CH, Campbell JD, Davis ML, Jupiter DC. Incidence of acute deep vein thrombosis and pulmonary embolism in foot and ankle trauma: analysis of the national trauma data bank. J Foot Ankle Surg. 2012;51:63–8.

    PubMed  Google Scholar 

  86. Zamanian RT, Hansmann G, Snook S, Lilienfeld D, Rappaport KM, Reaven GM, Rabinovitch M, Doyle RL. Insulin resistance in pulmonary arterial hypertension. Eur Respir J. 2009;33:318–24.

    CAS  PubMed Central  PubMed  Google Scholar 

  87. Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant. 2011;30:904–11.

    PubMed Central  PubMed  Google Scholar 

  88. Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, et al. An antiproliferative bmp-2/ppargamma/apoe axis in human and murine smcs and its role in pulmonary hypertension. J Clin Invest. 2008;118:1846–57.

    CAS  PubMed Central  PubMed  Google Scholar 

  89. Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation. 2007;115:1275–84.

    CAS  PubMed  Google Scholar 

  90. Dominguez-Cherit G, Lapinsky SE, Macias AE, Pinto R, Espinosa-Perez L, de la Torre A, Poblano-Morales M, Baltazar-Torres JA, Bautista E, Martinez A, et al. Critically ill patients with 2009 influenza a(h1n1) in mexico. JAMA. 2009;302:1880–7.

    CAS  PubMed  Google Scholar 

  91. Fezeu L, Julia C, Henegar A, Bitu J, Hu FB, Grobbee DE, Kengne AP, Hercberg S, Czernichow S. Obesity is associated with higher risk of intensive care unit admission and death in influenza a (h1n1) patients: a systematic review and meta-analysis. Obes Rev. 2011;12:653–9.

    CAS  PubMed  Google Scholar 

  92. Paich HA, Sheridan PA, Handy J, Karlsson EA, Schultz-Cherry S, Hudgens MG, Noah TL, Weir SS, Beck MA. Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 Influenza a virus. Obesity. 2013:2377–86.

    Google Scholar 

  93. Karlsson EA, Sheridan PA, Beck MA. Diet-induced obesity impairs the t cell memory response to influenza virus infection. J Immunol. 2010;184:3127–33.

    CAS  PubMed  Google Scholar 

  94. Smith AG, Sheridan PA, Harp JB, Beck MA. Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. J Nutr. 2007;137:1236–43.

    CAS  PubMed  Google Scholar 

  95. Smith AG, Sheridan PA, Tseng RJ, Sheridan JF, Beck MA. Selective impairment in dendritic cell function and altered antigen-specific cd8+ t-cell responses in diet-induced obese mice infected with influenza virus. Immunology. 2009;126:268–79.

    CAS  PubMed Central  PubMed  Google Scholar 

  96. Corrales-Medina VF, Valayam J, Serpa JA, Rueda AM, Musher DM. The obesity paradox in community-acquired bacterial pneumonia. Int J Infect Dis. 2011;15:e54–7.

    PubMed  Google Scholar 

  97. Inoue Y, Koizumi A, Wada Y, Iso H, Watanabe Y, Date C, Yamamoto A, Kikuchi S, Inaba Y, Toyoshima H, et al. Risk and protective factors related to mortality from pneumonia among middleaged and elderly community residents: the jacc study. J Epidemiol. 2007;17:194–202.

    PubMed  Google Scholar 

  98. Baik I, Curhan GC, Rimm EB, Bendich A, Willett WC, Fawzi WW. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in us men and women. Arch Intern Med. 2000;160:3082–8.

    CAS  PubMed  Google Scholar 

  99. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J Immunol. 2002;168:4018–24.

    CAS  PubMed  Google Scholar 

  100. Mancuso P, Huffnagle GB, Olszewski MA, Phipps J, Peters-Golden M. Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med. 2006;173:212–8.

    CAS  PubMed  Google Scholar 

  101. Moss M, Guidot DM, Steinberg KP, Duhon GF, Treece P, Wolken R, Hudson LD, Parsons PE. Diabetic patients have a decreased incidence of acute respiratory distress syndrome. Crit Care Med. 2000;28:2187–92.

    CAS  PubMed  Google Scholar 

  102. Iscimen R, Cartin-Ceba R, Yilmaz M, Khan H, Hubmayr RD, Afessa B, Gajic O. Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study. Crit Care Med. 2008;36:1518–22.

    PubMed  Google Scholar 

  103. Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med. 2005;33:1191–8.

    PubMed  Google Scholar 

  104. Wright JK, Nwariaku FN, Clark J, Falck JC, Rogers T, Turnage RH. Effect of diabetes mellitus on endotoxin-induced lung injury. Arch Surg. 1999;134:1354–8. discussion 1358–1359.

    CAS  PubMed  Google Scholar 

  105. Boichot E, Sannomiya P, Escofier N, Germain N, Fortes ZB, Lagente V. Endotoxin-induced acute lung injury in rats. Role of insulin. Pulm Pharmacol Ther. 1999;12:285–90.

    CAS  PubMed  Google Scholar 

  106. Alba-Loureiro TC, Martins EF, Landgraf RG, Jancar S, Curi R, Sannomiya P. Role of insulin on pge2 generation during lps-induced lung inflammation in rats. Life Sci. 2006;78:578–85.

    CAS  PubMed  Google Scholar 

  107. de Oliveira Martins J, Meyer-Pflug AR, Alba-Loureiro TC, Melbostad H, Costa da Cruz JW, Coimbra R, Curi R, Sannomiya P. Modulation of lipopolysaccharide-induced acute lung inflammation: role of insulin. Shock. 2006;25:260–6.

    PubMed  Google Scholar 

  108. Alba-Loureiro TC, Munhoz CD, Martins JO, Cerchiaro GA, Scavone C, Curi R, Sannomiya P. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res. 2007;40:1037–44.

    CAS  PubMed  Google Scholar 

  109. Moreno-Navarrete JM, Fernandez-Real JM. Antimicrobial-sensing proteins in obesity and type 2 diabetes: the buffering efficiency hypothesis. Diabetes Care. 2011;34 Suppl 2:S335–41.

    CAS  PubMed Central  PubMed  Google Scholar 

  110. Moutschen MP, Scheen AJ, Lefebvre PJ. Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections. Diabete Metab. 1992;18:187–201.

    CAS  PubMed  Google Scholar 

  111. O'Brien Jr JM, Phillips GS, Ali NA, Lucarelli M, Marsh CB, Lemeshow S. Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med. 2006;34:738–44.

    PubMed Central  PubMed  Google Scholar 

  112. O'Brien Jr JM, Welsh CH, Fish RH, Ancukiewicz M, Kramer AM. Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury. Ann Intern Med. 2004;140:338–45.

    PubMed  Google Scholar 

  113. Morris AE, Stapleton RD, Rubenfeld GD, Hudson LD, Caldwell E, Steinberg KP. The association between body mass index and clinical outcomes in acute lung injury. Chest. 2007;131:342–8.

    PubMed  Google Scholar 

  114. Walz JM, Zayaruzny M, Heard SO. Airway management in critical illness. Chest. 2007;131:608–20.

    PubMed  Google Scholar 

  115. Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM. Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med. 2007;175:587–94.

    CAS  PubMed Central  PubMed  Google Scholar 

  116. Barazzone-Argiroffo C, Muzzin P, Donati YR, Kan CD, Aubert ML, Piguet PF. Hyperoxia increases leptin production: a mechanism mediated through endogenous elevation of corticosterone. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1150–6.

    CAS  PubMed  Google Scholar 

  117. Shore SA, Lang JE, Kasahara DI, Lu FL, Verbout NG, Si H, Williams ES, Terry RD, Lee A, Johnston RA. Pulmonary responses to subacute ozone exposure in obese vs. lean mice. J Appl Physiol. 2009;107:1445–52.

    CAS  PubMed Central  PubMed  Google Scholar 

  118. Lu FL, Johnston RA, Flynt L, Theman TA, Terry RD, Schwartzman IN, Lee A, Shore SA. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol. 2006;290:L856–65.

    CAS  PubMed  Google Scholar 

  119. Johnston RA, Theman TA, Lu FL, Terry RD, Williams ES, Shore SA. Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. J Appl Physiol. 2008;104:1727–35.

    CAS  PubMed  Google Scholar 

  120. Stapleton RD, Dixon AE, Parsons PE, Ware LB, Suratt BT. The association between bmi and plasma cytokine levels in patients with acute lung injury. Chest. 2010;138:568–77.

    CAS  PubMed Central  PubMed  Google Scholar 

  121. Hiestand DM, Britz P, Goldman M, Phillips B. Prevalence of symptoms and risk of sleep apnea in the us population: results from the national sleep foundation sleep in america 2005 poll. Chest. 2006;130:780–6.

    PubMed  Google Scholar 

  122. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–5.

    CAS  PubMed  Google Scholar 

  123. Smolensky MH, Di Milia L, Ohayon MM, Philip P. Sleep disorders, medical conditions, and road accident risk. Accid Anal Prev. 2011;43:533–48.

    PubMed  Google Scholar 

  124. Loke YK, Brown JW, Kwok CS, Niruban A, Myint PK. Association of obstructive sleep apnea with risk of serious cardiovascular events: systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2012;5(5):720–8.

    PubMed  Google Scholar 

  125. Goncalves MA, Paiva T, Ramos E, Guilleminault C. Obstructive sleep apnea syndrome, sleepiness, and quality of life. Chest. 2004;125:2091–6.

    PubMed  Google Scholar 

  126. Isono S. Obesity and obstructive sleep apnoea: mechanisms for increased collapsibility of the passive pharyngeal airway. Respirology. 2012;17:32–42.

    PubMed  Google Scholar 

  127. Opp MR. Cytokines and sleep. Sleep Med Rev. 2005;9:355–64.

    PubMed  Google Scholar 

  128. Phillips BG, Kato M, Narkiewicz K, Choe I, Somers VK. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea. Am J Physiol Heart Circ Physiol. 2000;279:H234–7.

    CAS  PubMed  Google Scholar 

  129. Polotsky VY, Wilson JA, Smaldone MC, Haines AS, Hurn PD, Tankersley CG, Smith PL, Schwartz AR, O'Donnell CP. Female gender exacerbates respiratory depression in leptin-deficient obesity. Am J Respir Crit Care Med. 2001;164:1470–5.

    CAS  PubMed  Google Scholar 

  130. Malli F, Papaioannou AI, Gourgoulianis KI, Daniil Z. The role of leptin in the respiratory system: an overview. Respir Res. 2010;11:152.

    PubMed Central  PubMed  Google Scholar 

  131. Wheatley JR, Mezzanotte WS, Tangel DJ, White DP. Influence of sleep on genioglossus muscle activation by negative pressure in normal men. Am Rev Respir Dis. 1993;148:597–605.

    CAS  PubMed  Google Scholar 

  132. Tangel DJ, Mezzanotte WS, Sandberg EJ, White DP. Influences of nrem sleep on the activity of tonic vs. inspiratory phasic muscles in normal men. J Appl Physiol. 1992;73:1058–66.

    CAS  PubMed  Google Scholar 

  133. Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep. Chest. 2009;135:957–64.

    PubMed  Google Scholar 

  134. Schotland HM, Insko EK, Schwab RJ. Quantitative magnetic resonance imaging demonstrates alterations of the lingual musculature in obstructive sleep apnea. Sleep. 1999;22:605–13.

    CAS  PubMed  Google Scholar 

  135. Drager LF, Lopes HF, Maki-Nunes C, Trombetta IC, Toschi-Dias E, Alves MJ, Fraga RF, Jun JC, Negrao CE, Krieger EM, et al. The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome. PLoS One. 2010;5:e12065.

    PubMed Central  PubMed  Google Scholar 

  136. Polotsky VY, Patil SP, Savransky V, Laffan A, Fonti S, Frame LA, Steele KE, Schweizter MA, Clark JM, Torbenson MS, et al. Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity. Am J Respir Crit Care Med. 2009;179:228–34.

    PubMed Central  PubMed  Google Scholar 

  137. Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol. 2009;106:1538–44.

    CAS  PubMed Central  PubMed  Google Scholar 

  138. Surani S, Subramanian S. Effect of continuous positive airway pressure therapy on glucose control. World J Diabetes. 2012;3:65–70.

    PubMed Central  PubMed  Google Scholar 

  139. Park JG, Ramar K, Olson EJ. Updates on definition, consequences, and management of obstructive sleep apnea. Mayo Clin Proc. 2011;86:549–54. quiz 554-545.

    PubMed Central  PubMed  Google Scholar 

  140. Foster GD, Borradaile KE, Sanders MH, Millman R, Zammit G, Newman AB, Wadden TA, Kelley D, Wing RR, Pi-Sunyer FX, et al. A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the sleep ahead study. Arch Intern Med. 2009;169:1619–26.

    PubMed Central  PubMed  Google Scholar 

  141. Chau EH, Lam D, Wong J, Mokhlesi B, Chung F. Obesity hypoventilation syndrome: a review of epidemiology, pathophysiology, and perioperative considerations. Anesthesiology. 2012;117:188–205.

    PubMed  Google Scholar 

  142. Littleton SW, Mokhlesi B. The pickwickian syndrome-obesity hypoventilation syndrome. Clin Chest Med. 2009;30:467–78. Vii–viii.

    PubMed  Google Scholar 

  143. Jennum P, Kjellberg J. Health, social and economical consequences of sleep-disordered breathing: a controlled national study. Thorax. 2011;66:560–6.

    PubMed  Google Scholar 

  144. Lee WY, Mokhlesi B. Diagnosis and management of obesity hypoventilation syndrome in the icu. Crit Care Clin. 2008;24:533–49. vii.

    PubMed  Google Scholar 

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Chapman, D.G., Suratt, B.T., Dixon, A.E. (2014). Respiratory Diseases in Obesity. In: Fantuzzi, G., Braunschweig, C. (eds) Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-770-9_19

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