From Columbus to TsimTsoum Concepts: A Kyoto-Type Approach

Abstract

Chronic degenerative diseases, mind ↔ body ill-health apparently just reflects the human response to environment. Here they are under the acronym of non-communicable diseases. Chronic degenerative diseases represent some 85% of all causes of reported death worldwide (1). The rhythmically evolving interaction between mind and body—transcribed in the Eastern transcending yin-yang visualization of dynamism is opposed to thermodynamism and homeostasis. Dynamism has led to the inception of modern chronobiology, and more recently of chronomics, a Western time-structure evidence-based approach to an environment-led and -controlled human mind ↔ body health (2). Vascular rhythms are harbingers of pre-metabolic syndrome and it becomes more important to focus on the mind ↔ body interaction in the justification of an alarming explosion of non-communicable diseases. The “mind stress ↔ body strain” condition leading to tissue injuries and “modern” chronic degenerative diseases has become scientifically self-evidence (Fig. 22.1). Ignoring such evidence may be a factor promoting non-communicable diseases (3).

Appendices

Appendix 1

Cell membrane fatty acids as they appear seen from the cell surface (Fig. 22.11).

Fig. 22.11.

Allylic double bonds in cell membrane fatty acids seen from their chemical distance from the surface. In the plant kingdom, the original C18Δ9db in oleic acid (OA: C18:1ω9) evolved to the C18Δ9,12db in linoleic acid (LA: C18:2ω6) and the C18Δ9,12,15db in alpha-linolenic acid (ALA: C18:3ω3), each db moving further away from the cell membrane surface. First attempts at adding additional allylic double bonds appear to have resulted in an evolutionary dead-end with the C18Δ69,12db in gamma-linoleic acid (GLA: C18:3ω6) and C18Δ6,9,12,15db in stearidonic acid (SDA: C18:4ω3). Next successful evolutionary quantum leap appears to have been in the direction of elongating the chain to C20 (with no apparent evolutionary advantage) prior to its next desaturation, leading to the two well-known cell membrane isomers C20Δ58,11,14db in arachidonic acid (AA: C20:4ω6) and C20Δ58,11,14,17db in eicosapentaenoic acid (EPA: C20:5ω3). Note that the 2C elongation process prior to the 3C allylic desaturation allows for all previously evolutionary selected db to move 1C forward towards the cell membrane surface. The ultimate elongation–desaturation evolutionary quantum leap (so far) led to the appearance of the two IT-functional isomers C22Δ47,10,13,16db in docosapentaenoic acid (DPA: C22:5ω6) and C22Δ47,10,13,16,19db in docosahexaenoic acid (DHA: C22:6ω3).

Appendix 2. From Evolutionary Standards to Humanity: A Mind Theory at Molecular Level

The permanent six cell membrane nonessential (SA and OA) and essential (EPA/DHA and LA/AA) fatty acids of advanced living species representing the animal kingdom are the basis for their communicative sound-based skills and the inception of memory from a remote past starting with emotion (Fig. 22.12):

Fig. 22.12.

From emotion to memory as a function of complexity. As the complexity of the environmental information increases, it leaves more and more superficial imprint in the memory as a result of the reduction of entropy of the associative network needed to retain it.

Emotion  →  Sound  →  Basic Expression  →  Deep Imprint  →  Memory

How Can It Possibly Work Altogether?

Three basic sound waves appear sufficient to support the inception and evolution of languages and writings to their current standards. A byte contains enough information to store a single ASCII character, like “h”; a 5-tit Tyte (EPA) must do the job as well (Table 22.6).

Table 22.6 ASCII characters imprinted in spins

The memetic code therefore appears to be a lipid, more specifically, a 3-fatty acids (DHA, EPA, and AA) affair that are able to absorb and assemble sound waves of three different range of complexities (basic sounds of ±40 vowels and consonants, characters of ±120 characters, composed sounds of ±365 syllables) to develop and support continuous development of language and culture; i.e., Humanity (Fig. 22.13).

Fig. 22.13.

DHA and the inception of conception. It can be shown that any ASCII character or syllabic sound (syllable) can spontaneously emanate from a three spin informational system in-built in the double bonds of unsaturated fatty acid carbon chains. Each double bond can theoretically record three types of information in terms of definite wave (sine curve) unit characteristics; i.e., its peak time, its amplitude, and its period/frequency.