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The Role of Probiotics in Atopic Dermatitis (Eczema) and Skin Allergy Reactions: Prevention and Therapy

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Bioactive Dietary Factors and Plant Extracts in Dermatology

Part of the book series: Nutrition and Health ((NH))

Abstract

Development of the child’s immune system tends to be directed toward a T-helper 2 (Th2) phenotype in infants, whereas postnatal maturation is associated with gradual inhibition of Th2 and increasing Th1 affinity [19]. Thus, immature Th2-dominant neonatal responses must undergo environment-driven maturation via microbial contact in the early postnatal period to prevent development of childhood allergic diseases. Nevertheless, nowadays the increased use of antimicrobial medication, the consumption of sterile food, and reduced family size that result in lower rates of infection during childhood also reduce early contact to microbes. Consequentially, at an early age the infant’s immune system results in subsequent polarization toward a Th2 phenotype during postnatal maturation. Among several other phenomena, the present increase in allergic diseases seen in the industrialized countries has been attributed, to a relative lack of microbial stimulation of the infantile gut immune system and the exaggerated hygiene of the typical western lifestyle during early childhood. And this is known as the hygiene hypothesis [20].

An erratum to this chapter is available at http://dx.doi.org/10.1007/978-1-62703-167-7_49

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-1-62703-167-7_49

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Authors and Affiliations

  1. Göztepe Research and Training Hospital, Department of Pediatrics, Division of Allergy/Immunology, İstanbul Medeniyet University, Ministry of Health, Republic of Turkey, Göztepe, Kadıköy, İstanbul, Türkiye

    Öner Özdemir M.D.

  2. Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Medical college campus, Off satara road, Dhankawadi, Pune, 411043, Maharashtra, India

    Anand A. Zanwar

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  1. Öner Özdemir M.D.
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Correspondence to Öner Özdemir M.D. .

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  1. University of Arizona Mel and, Enid Zuckerman College of Public Health, Division of Health Promotion Sciences, University of Arizona School of Medicine, Tuscon, 85724, Arizona, USA

    Ronald Ross Watson

  2. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Özdemir, Ö., Zanwar, A.A. (2013). The Role of Probiotics in Atopic Dermatitis (Eczema) and Skin Allergy Reactions: Prevention and Therapy. In: Watson, R., Zibadi, S. (eds) Bioactive Dietary Factors and Plant Extracts in Dermatology. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-167-7_48

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