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Genomic Structural Variants pp 273–289Cite as

Online Resources for Genomic Structural Variation

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 838))

Abstract

Genomic structural variation (SV) can be thought of on a continuum from a single base pair insertion/deletion (INDEL) to large megabase-scale rearrangements involving insertions, deletions, duplications, inversions, or translocations of whole chromosomes or chromosome arms. These variants can occur in coding or noncoding DNA, they can be inherited or arise sporadically in the germline or somatic cells. Many of these events are segregating in the population and can be considered common alleles while others are new alleles and thus rare events. All species studied to date harbor structural variants and these may be benign, contributing to phenotypes such as sensory perception and immunity, or pathogenic resulting in genomic disorders including DiGeorge/velocardiofacial, Smith-Margenis, Williams-Beuren, and Prader-Willi syndromes. As structural variants are identified, validated, and their significance, origin, and prevalence are elucidated, it is of critical importance that these data be collected and collated in a way that can be easily accessed and analyzed. This chapter describes current structural variation online resources (see Fig. 1 and Table 1), highlights the challenges in capturing, storing, and displaying SV data, and discusses how dbVar and DGVa, the genomic structural variation databases developed at NCBI and EBI, respectively, were designed to address these issues.

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Acknowledgments

This research was supported (in part) by the Intramural Research Program of the NIH, National Library of Medicine.

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  1. NCBI, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA

    Tam P. Sneddon & Deanna M. Church

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Correspondence to Deanna M. Church .

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    Lars Feuk

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Sneddon, T.P., Church, D.M. (2012). Online Resources for Genomic Structural Variation. In: Feuk, L. (eds) Genomic Structural Variants. Methods in Molecular Biology, vol 838. Springer, New York, NY. https://doi.org/10.1007/978-1-61779-507-7_13

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  • DOI: https://doi.org/10.1007/978-1-61779-507-7_13

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