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Checkpoint Controls and Targets in Cancer Therapy pp 27–36Cite as

Distinct Pathways Involved in S-Phase Checkpoint Control

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The S-phase checkpoint is activated when DNA damage occurs during DNA synthesis or when DNA replication intermediates accumulate. Depending on the type and magnitude of damage, cells activate one of the three distinct S-phase checkpoint pathways: (1) an intra-S-phase checkpoint induced by double strand break, (2) a replication checkpoint by the stalled replication fork, and (3) a S–M checkpoint to block premature mitosis. These checkpoint pathways coordinate a network of signaling molecules and are thought to ensure the fidelity of the replicating genome.

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Acknowledgment:

This work was supported by the Flight Attendant Medical Research Institute (P.J. Hurley and F. Bunz).

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Authors and Affiliations

  1. Department of Radiation Oncology and Molecular Radiation Sciences and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA

    Paula J. Hurley & Fred Bunz

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  1. Paula J. Hurley
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  2. Fred Bunz
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Editors and Affiliations

  1. M.D. Anderson Cancer Center, University of Texas, Holcombe Blvd. 1515, Houston, 77030, U.S.A.

    Zahid H. Siddik

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Hurley, P.J., Bunz, F. (2010). Distinct Pathways Involved in S-Phase Checkpoint Control. In: Siddik, Z. (eds) Checkpoint Controls and Targets in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-60761-178-3_2

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  • DOI: https://doi.org/10.1007/978-1-60761-178-3_2

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