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Regulation of Iron Absorption and Distribution

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Iron Deficiency and Overload

Part of the book series: Nutrition and Health ((NH))

Summary

• Iron absorption and distribution are determined by the activities of iron transport and storage proteins.

• Absorption of iron by the epithelial cells of the proximal gastrointestinal tract is a highly regulated physiological process that maintains body iron homeostasis.

• Iron efflux from cells occurs through the transporter ferroportin.

• Hepcidin is a plasma peptide that regulates plasma iron levels by controlling the iron export function of ferroportin and thereby also regulates iron absorption and distribution.

• Other mechanisms exist within cells to modulate the activity of iron transport and storage systems in response to cellular iron levels.

• Disordered iron distribution in the body occurs in chronic inflammatory conditions.

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  1. Nutrition Research Division, Department of Biochemistry, King’s College London, London, UK

    Gladys Oluyemisi Latunde-Dada PHD & Robert J. Simpson DPHIL

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  1. Gladys Oluyemisi Latunde-Dada PHD
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  1. Dept. Psychology, Bar-Ilan University, Ramat Gan, 52900, Israel

    Shlomo Yehuda

  2. Dept. Psychology, Boston University, Cummington St. 64, Boston, 02215-2407, USA

    David I. Mostofsky

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Latunde-Dada, G.O., Simpson, R.J. (2009). Regulation of Iron Absorption and Distribution. In: Yehuda, S., Mostofsky, D. (eds) Iron Deficiency and Overload. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-462-9_2

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