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Cancer Genomics

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The Molecular Basis of Human Cancer

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Abstract

Cancer results from genetic and epigenetic aberrations, many of which alter the levels of expressed genes and proteins. In the past, cancer researchers have studied genes mainly one at a time. Increasingly, researchers are using genomic technologies like DNA microarrays and next-generation DNA sequencing to investigate thousands of genes simultaneously, defining genes and pathways relevant to cancer mechanisms, diagnosis, prognostication, and treatment. This chapter details genomics technologies, their use and applications in cancer research, and their potential utility in oncologic practice.

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Authors and Affiliations

  1. Department of Pathology, Stanford University, 269 Campus Drive, CCSR-3245A, Stanford, CA, 94305-5176, USA

    Jonathan R. Pollack M.D., Ph.D.

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  1. Jonathan R. Pollack M.D., Ph.D.
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Correspondence to Jonathan R. Pollack M.D., Ph.D. .

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  1. Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Program in Translational Medicine, UNC Lineberger Comprehensive Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    William B. Coleman

  2. Laboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, Hanover, New Hampshire, USA

    Gregory J. Tsongalis

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Pollack, J.R. (2017). Cancer Genomics. In: Coleman, W., Tsongalis, G. (eds) The Molecular Basis of Human Cancer. Humana Press, New York, NY. https://doi.org/10.1007/978-1-59745-458-2_3

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