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Equality of the Sexes? Parent-of-Origin Effects on Transcription and de novo Mutations

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Bioinformatics for Systems Biology

Abstract

Two main categories of the parent-of-origin effects are reviewed in this chapter: parent-of-origin effects on transcription, or genomic imprinting, and parent-of-origin effects on the development of de novo mutations. Each type of parent-of-origin effect is described, and the mechanisms that contribute to each discussed. The parent-of-origin effect database provides a catalog reports of genomic imprinting and related effects as well as reports of the parental origin of spontaneous mutations. This database provides a useful tool for finding genes, diseases, or traits that exhibit a parent-of-origin effect in humans and animals, conducting comparative analyses of the imprinted genes among different species, and examining the role of parent-of-origin effects for different types of spontaneous mutations in human genes.

Portions of this chapter are reproduced with some modification from R. L. Glaser, E. W. Jabs, Dear Old Dad. Sci. Aging Knowl. Environ. 2004 (3), re1 (2004).

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Authors and Affiliations

  1. Department of Biological Sciences, Stevenson University, 1525 Greenpring Valley Road, Stevenson, Maryland, 21153, USA

    Rivka L. Glaser

  2. University of Otago, Dunedin, New Zealand

    Ian M. Morison

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    Stephen Krawetz

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Glaser, R.L., Morison, I.M. (2009). Equality of the Sexes? Parent-of-Origin Effects on Transcription and de novo Mutations. In: Krawetz, S. (eds) Bioinformatics for Systems Biology. Humana Press. https://doi.org/10.1007/978-1-59745-440-7_26

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