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Extended-Release Oral Drug Delivery Technologies: Monolithic Matrix Systems

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Drug Delivery Systems

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 437))

Abstract

Oral drug delivery is the largest and the oldest segment of the total drug delivery market. It is the fastest growing and most preferred route for drug administration. Use of hydrophilic matrices for oral extended release of drugs is a common practice in the pharmaceutical industry. This chapter presents different polymer choices for fabrication of monolithic hydrophilic matrices and discusses formulation and manufacturing variables affecting the design and performance of the extended-release product by using selected practical examples.

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Acknowledgements

The authors thank Kurt Fegely, Dr. Marina Levina, Dr. Abhijit Gothoskar and Viena Diaz (all from Colorcon, Inc.) for their experimental contributions to the data presented in this chapter.

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Authors and Affiliations

  1. Modified Release Technologies, Colorcon, West Point, PA

    Sandip B. Tiwari

  2. Colorcon, West Point, PA

    Ali R. Rajabi-Siahboomi

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  1. Sandip B. Tiwari
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  1. Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain

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Tiwari, S.B., Rajabi-Siahboomi, A.R. (2008). Extended-Release Oral Drug Delivery Technologies: Monolithic Matrix Systems. In: Jain, K.K. (eds) Drug Delivery Systems. Methods in Molecular Biology™, vol 437. Humana Press. https://doi.org/10.1007/978-1-59745-210-6_11

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  • DOI: https://doi.org/10.1007/978-1-59745-210-6_11

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