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Dual Function of Notch Signaling in Cancer: Oncogene and Tumor Suppressor

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Book cover Targeting Notch in Cancer

Abstract

The Notch cascade is an evolutionarily conserved cell-to-cell signaling system that regulates many aspects of embryonic development. It regulates also self-renewal and differentiation processes as well as tissue homeostasis in several adult vertebrate organs. In the last 15 years, it has become evident that deregulated Notch signaling is associated with several human disorders, including cancer. Recently, large sequencing efforts of cancer genomes have uncovered both gain- and loss-of-function mutations in different genes involved in the Notch signaling cascade, indicating that Notch can be both oncogenic and tumor suppressive. For specific tumor types, results generated from experimental mouse models predicted and also validated such relationships, whereas for others, the conclusive findings were unanticipated. The oncogenic and tumor-suppressive functions of Notch appear to be context- and tissue-specific. In this review we will discuss the context-dependent and tissue-specific oncogenic and tumor-suppressive functions of Notch.

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  1. Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland

    Ute Koch & Freddy Radtke

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  1. Ute Koch
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Correspondence to Ute Koch or Freddy Radtke .

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  1. Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Lucio Miele

  2. Department of Cell Biology, Harvard Medical School, Boston, MA, USA

    Spyros Artavanis-Tsakonas

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Koch, U., Radtke, F. (2018). Dual Function of Notch Signaling in Cancer: Oncogene and Tumor Suppressor. In: Miele, L., Artavanis-Tsakonas, S. (eds) Targeting Notch in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-8859-4_3

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