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Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing

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Immunotoxicity Testing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1803))

Abstract

Immune-based childhood diseases and conditions, including allergic diseases and asthma, recurrent otitis media, pediatric celiac disease, and type 1 diabetes have been on the rise over the past decades. As a result, the use of developmental immunotoxicity (DIT) testing to identify potential environmental risk factors contributing to these and other diseases has become a priority for scientists across sectors. This chapter serves to provide insight into the scientific basis for DIT and determining the necessity of DIT testing and offers recommendations for DIT testing parameters to optimize sensitivity, power, and concordance among DIT assays.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA

    Annalise N. vonderEmbse & Jamie C. DeWitt

Authors
  1. Annalise N. vonderEmbse
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  2. Jamie C. DeWitt
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Corresponding author

Correspondence to Jamie C. DeWitt .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Toxicology, East Carolina University, Greenville, North Carolina, USA

    Jamie C. DeWitt

  2. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA

    Cheryl E. Rockwell

  3. Durham, North Carolina, USA

    Christal C. Bowman

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© 2018 Springer Science+Business Media, LLC, part of Springer Nature

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vonderEmbse, A.N., DeWitt, J.C. (2018). Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing. In: DeWitt, J., Rockwell, C., Bowman, C. (eds) Immunotoxicity Testing. Methods in Molecular Biology, vol 1803. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8549-4_4

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  • DOI: https://doi.org/10.1007/978-1-4939-8549-4_4

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8548-7

  • Online ISBN: 978-1-4939-8549-4

  • eBook Packages: Springer Protocols

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