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MicroRNA and Cancer pp 23–43Cite as

MicroRNAs in Breast Cancer: Diagnostic and Therapeutic Potential

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1699))

Abstract

MicroRNAs (miRNAs) are a large family of small, approximately 20–22 nucleotide, noncoding RNAs that regulate the expression of target genes, at the post-transcriptional level. miRNAs are involved in virtually diverse biological processes and play crucial roles in cellular processes, such as cell differentiation, proliferation, and apoptosis. Accumulating lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are associated with the onset of many diseases, including cancer. It is possible that the diverse roles that miRNAs play, have potential to provide valuable information in a clinical setting, demonstrating the potential to act as both screening tools for the stratification of high-risk patients, while informing the treatment decision-making process. Increasing evidence suggests that some miRNAs may even provide assistance in the diagnosis of patients with breast cancer. In addition, miRNAs may themselves be considered therapeutic targets, with inhibition or reintroduction of a particular miRNA capable of inducing a response in-vivo. This chapter discusses the role of miRNAs as oncogenes and tumor suppressors in breast cancer development and metastasis . It focuses on miRNAs that have prognostic, diagnostic, or predictive potential in breast cancer as well as the possible challenges in the translation of such observations to the clinic.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, University of Kashmir, Hazratbal Srinagar, J&K, 190006, India

    Asia Asiaf & Mohammad Afzal Zargar

  2. Clarke H. Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, 2A25 HRIC, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada

    Shiekh Tanveer Ahmad

  3. Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, 2A32 HRIC, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada

    Wani Arjumand

Authors
  1. Asia Asiaf
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  2. Shiekh Tanveer Ahmad
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  3. Wani Arjumand
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  4. Mohammad Afzal Zargar
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Corresponding author

Correspondence to Mohammad Afzal Zargar .

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Editors and Affiliations

  1. Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California in San Francisco, San Francisco, California, USA

    Wei Wu

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Asiaf, A., Ahmad, S.T., Arjumand, W., Zargar, M.A. (2018). MicroRNAs in Breast Cancer: Diagnostic and Therapeutic Potential. In: Wu, W. (eds) MicroRNA and Cancer. Methods in Molecular Biology, vol 1699. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7435-1_2

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  • DOI: https://doi.org/10.1007/978-1-4939-7435-1_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7433-7

  • Online ISBN: 978-1-4939-7435-1

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