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Gene Expression Analysis: Current Methods

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Molecular Pathology in Cancer Research

Abstract

Cancer is a genetic disease characterised by multiple heterogeneous genetic and epigenetic changes. Recent studies have identified extensive heterogeneity between and within tumours [1–3]. The genes in a cell need to be studied as a functioning collective in order to tease apart and understand the myriad different levels of processes and interactions that are coordinated towards the common goal of assuring vital functioning of a cell. The study of the transcriptome of cancer cells, a fundamental link between genotype and phenotype, is essential to understanding the complexity of cancer evolution.

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Authors and Affiliations

  1. Translational Breast Cancer Genomics and Therapeutics Lab, Cancer Therapeutics Program, Division of Research, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia

    Zhi Ling Teo, Peter Savas & Sherene Loi

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  1. Zhi Ling Teo
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  2. Peter Savas
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  3. Sherene Loi
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Correspondence to Sherene Loi .

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  1. UQ Centre for Clinical Research, The Royal Brisbane and Women’s Hospital, University of Queensland and Pathology Queensland, Brisbane, Queensland, Australia

    Sunil R. Lakhani

  2. Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia

    Stephen B. Fox

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Teo, Z.L., Savas, P., Loi, S. (2016). Gene Expression Analysis: Current Methods. In: Lakhani, S., Fox, S. (eds) Molecular Pathology in Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6643-1_6

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