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Animal Models of Addiction: Genetic Influences

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Animal Models of Behavior Genetics

Part of the book series: Advances in Behavior Genetics ((AIBG))

Abstract

Animal models employing selection or selective breeding practices based on phenotypic traits related to substance use disorders have enhanced our understanding of the role genes play in the vulnerability to such compulsive behaviors. Rodent models, in particular, have shown that traits such as impulsivity and high sweet consumption, among others, are under strong genetic influence and positively associated with drug intake, similar to human populations. This chapter will review a number of rat models of phenotypic vulnerability to and protection from drug abuse. It will compare and contrast these models and assess whether they provide evidence for one or multiple addiction-prone phenotypes, and conclude by assessing the potential utility of these models in predicting clinical outcomes in treating substance use disorders.

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References

  • Acewicz, A., Mierzejewski, P., Dyr, W., Jastrzebska, A., Korkosz, I., Wyszogrodzka, E., et al. (2012). Cocaine self-administration in Warsaw alcohol high-preferring (WHP) and Warsaw alcohol low-preferring (WLP) rats. European Journal of Pharmacology, 674(2-3), 275–279.

    Article  CAS  PubMed  Google Scholar 

  • Agrawal, A., & Lynskey, M. T. (2008). Are there genetic influences on addiction: Evidence from family, adoption and twin studies. Addiction, 103(7), 1069–1081.

    Article  PubMed  Google Scholar 

  • Agrawal, A., Verweij, K. J., Gillespie, N. A., Heath, A. C., Lessov-Schlaggar, C. N., Martin, N. G., et al. (2012). The genetics of addiction-a translational perspective. Translational Psychiatry, 2, e140.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aldao, A., Nolen-Hoeksema, S., & Schweizer, S. (2010). Emotion-regulation strategies across psychopathology: A meta-analytic review. Clinical Psychology Review, 30(2), 217–237.

    Article  PubMed  Google Scholar 

  • Alsop, B. (2007). Problems with spontaneously hypertensive rats (SHR) as a model of attention-deficit/hyperactivity disorder (AD/HD). Journal of Neuroscience Methods, 162(1–2), 42–48.

    Article  PubMed  Google Scholar 

  • Ambrosio, E., Goldberg, S. R., & Elmer, G. I. (1995). Behavior genetic investigation of the relationship between spontaneous locomotor activity and the acquisition of morphine self-administration behavior. Behavioural Pharmacology, 6(3), 229–237.

    Article  CAS  PubMed  Google Scholar 

  • American Psychiatric Association, & Task Force on DSM-IV. (1994). Diagnostic and statistical manual of mental disorders: DSM-IV (4th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Anderson, K. G., & Diller, J. W. (2010). Effects of acute and repeated nicotine administration on delay discounting in Lewis and Fischer 344 rats. Behavioural Pharmacology, 21(8), 754–764.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Anker, J. J., & Carroll, M. E. (2011). Females are more vulnerable to drug abuse than males: Evidence from preclinical studies and the role of ovarian hormones. Current Topics in Behavioral Neurosciences, 8, 73–96.

    Article  CAS  PubMed  Google Scholar 

  • Anker, J. J., Gliddon, L. A., & Carroll, M. E. (2008). Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake. Behavioural Pharmacology, 19(5–6), 615–629.

    Article  CAS  PubMed  Google Scholar 

  • Anker, J. J., Holtz, N. A., & Carroll, M. E. (2012). Effects of progesterone on escalation of intravenous cocaine self-administration in rats selectively bred for high or low saccharin intake. Behavioural Pharmacology, 23(2), 205–210.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Anker, J. J., Perry, J. L., Gliddon, L. A., & Carroll, M. E. (2009a). Impulsivity predicts the escalation of cocaine self-administration in rats. Pharmacology, Biochemistry, and Behavior, 93(3), 343–348.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Anker, J. J., Zlebnik, N. E., Gliddon, L. A., & Carroll, M. E. (2009b). Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedure. Behavioural Pharmacology, 20(5–6), 406–414.

    Article  PubMed  Google Scholar 

  • Antoniou, K., Papathanasiou, G., Papalexi, E., Hyphantis, T., Nomikos, G. G., Spyraki, C., et al. (2008). Individual responses to novelty are associated with differences in behavioral and neurochemical profiles. Behavioural Brain Research, 187(2), 462–472.

    Article  CAS  PubMed  Google Scholar 

  • Armario, A., Gavalda, A., & Marti, J. (1995). Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats. Psychoneuroendocrinology, 20(8), 879–890.

    Article  CAS  PubMed  Google Scholar 

  • Atkins, A. L., Helms, M. L., O’Toole, L. A., & Belknap, J. K. (2001). Stereotypic behaviors in mice selectively bred for high and low methamphetamine-induced stereotypic chewing. Psychopharmacology, 157(1), 96–104.

    Article  CAS  PubMed  Google Scholar 

  • Badishtov, B. A., Overstreet, D. H., Kashevskaya, O. P., Viglinskaya, I. V., Kampov-Polevoy, A. B., Seredenin, S. B., et al. (1995). To drink or not to drink: Open field behavior in alcohol-preferring and nonpreferring rat strains. Physiology and Behavior, 57(3), 585–589.

    Article  CAS  PubMed  Google Scholar 

  • Baekeland, F., & Lundwall, L. (1975). Dropping out of treatment: A critical review. Psychological Bulletin, 82(5), 738–783.

    Article  CAS  PubMed  Google Scholar 

  • Bauman, A. E., Reis, R. S., Sallis, J. F., Wells, J. C., Loos, R. J., & Martin, B. W. (2012). Correlates of physical activity: Why are some people physically active and others not? Lancet, 380(9838), 258–271.

    Article  PubMed  Google Scholar 

  • Belin, D., Berson, N., Balado, E., Piazza, P. V., & Deroche-Gamonet, V. (2011). High-novelty-preference rats are predisposed to compulsive cocaine self-administration. Neuropsychopharmacology, 36(3), 569–579.

    Article  CAS  PubMed  Google Scholar 

  • Belin, D., Mar, A. C., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2008). High impulsivity predicts the switch to compulsive cocaine-taking. Science, 320(5881), 1352–1355.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Belknap, J. K., Haltli, N. R., Goebel, D. M., & Lame, M. (1983). Selective breeding for high and low levels of opiate-induced analgesia in mice. Behavior Genetics, 13(4), 383–396.

    Article  CAS  PubMed  Google Scholar 

  • Bell, R. L., Rodd, Z. A., Lumeng, L., Murphy, J. M., & McBride, W. J. (2006). The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addiction Biology, 11(3–4), 270–288.

    Article  PubMed  Google Scholar 

  • Berridge, K. C. (2012). From prediction error to incentive salience: Mesolimbic computation of reward motivation. European Journal of Neuroscience, 35(7), 1124–1143.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bjornebekk, A., Mathe, A. A., & Brene, S. (2005). The antidepressant effect of running is associated with increased hippocampal cell proliferation. International Journal of Neuropsychopharmacology, 8(3), 357–368.

    Article  CAS  PubMed  Google Scholar 

  • Blanchard, M. M., Mendelsohn, D., & Stamp, J. A. (2009). The HR/LR model: Further evidence as an animal model of sensation seeking. Neuroscience and Biobehavioral Reviews, 33(7), 1145–1154.

    Article  PubMed  Google Scholar 

  • Bock, G., & Whelan, J. (1992). Cocaine—Scientific and social dimensions. Chichester: J. Wiley.

    Book  Google Scholar 

  • Breland, K., & Breland, M. (1961). The misbehavior of organisms. American Psychologist, 16, 681–683.

    Article  Google Scholar 

  • Broos, N., Schmaal, L., Wiskerke, J., Kostelijk, L., Lam, T., Stoop, N., et al. (2012). The relationship between impulsive choice and impulsive action: A cross-species translational study. PloS One, 7(5), e36781.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Camp, D. M., Browman, K. E., & Robinson, T. E. (1994). The effects of methamphetamine and cocaine on motor behavior and extracellular dopamine in the ventral striatum of Lewis versus Fischer 344 rats. Brain Research, 668(1–2), 180–193.

    Article  CAS  PubMed  Google Scholar 

  • Carlson, K. R., & Perez, L. (1997). Ethanol and cocaine intake by rats selectively bred for oral opioid acceptance. Pharmacology, Biochemistry, and Behavior, 57(1–2), 309–313.

    Article  CAS  PubMed  Google Scholar 

  • Carmody, T. P., Vieten, C., & Astin, J. A. (2007). Negative affect, emotional acceptance, and smoking cessation. Journal of Psychoactive Drugs, 39(4), 499–508.

    Article  PubMed  Google Scholar 

  • Carroll, M. E., Anderson, M. M., & Morgan, A. D. (2007). Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake. Pharmacology, Biochemistry, and Behavior, 88(1), 94–104.

    Article  CAS  PubMed  Google Scholar 

  • Carroll, M. E., & Anker, J. J. (2010). Sex differences and ovarian hormones in animal models of drug dependence. Hormones and Behavior, 58(1), 44–56.

    Article  CAS  PubMed  Google Scholar 

  • Carroll, M. E., Anker, J. J., & Perry, J. L. (2009). Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory. Drug and Alcohol Dependence, 104(Suppl 1), S70–S78.

    Article  CAS  PubMed  Google Scholar 

  • Carroll, M. E., Morgan, A. D., Anker, J. J., Perry, J. L., & Dess, N. K. (2008). Selective breeding for differential saccharin intake as an animal model of drug abuse. Behavioural Pharmacology, 19(5–6), 435–460.

    Article  CAS  PubMed  Google Scholar 

  • Chaouloff, F., Kulikov, A., Sarrieau, A., Castanon, N., & Mormede, P. (1995). Male Fischer 344 and Lewis rats display differences in locomotor reactivity, but not in anxiety-related behaviours: Relationship with the hippocampal serotonergic system. Brain Research, 693(1–2), 169–178.

    Article  CAS  PubMed  Google Scholar 

  • Chen, F., Rezvani, A., Jarrott, B., & Lawrence, A. J. (1998). Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: In situ hybridisation histochemistry and receptor autoradiography. Neurochemistry International, 32(2), 143–151.

    Article  CAS  PubMed  Google Scholar 

  • Christensen, C. J., Kohut, S. J., Handler, S., Silberberg, A., & Riley, A. L. (2009). Demand for food and cocaine in Fischer and Lewis rats. Behavioral Neuroscience, 123(1), 165–171.

    Article  PubMed  Google Scholar 

  • Cools, A. R., & Gingras, M. A. (1998). Nijmegen high and low responders to novelty: A new tool in the search after the neurobiology of drug abuse liability. Pharmacology, Biochemistry, and Behavior, 60(1), 151–159.

    Article  CAS  PubMed  Google Scholar 

  • Crabbe, J. C. (2002). Genetic contributions to addiction. Annual Review of Psychology, 53, 435–462.

    Article  PubMed  Google Scholar 

  • Crabbe, J. C. (2008). Review. Neurogenetic studies of alcohol addiction. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 363(1507), 3201–3211.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cummings, J. A., Gowl, B. A., Westenbroek, C., Clinton, S. M., Akil, H., & Becker, J. B. (2011). Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats. Biology of Sex Differences, 2, 3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Darwin, C. (1874). The descent of man, and selection in relation to sex (2nd ed.). New York: A. L. Burt.

    Book  Google Scholar 

  • Davis, B. A., Clinton, S. M., Akil, H., & Becker, J. B. (2008). Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: Specific deficits in ‘waiting’ versus ‘stopping’. Pharmacology Biochemistry and Behavior, 90(3), 331–338.

    Google Scholar 

  • de Fiebre, N. C., Dawson, R., Jr., & de Fiebre, C. M. (2002). The selectively bred high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats differ in sensitivity to nicotine. Alcoholism: Clinical and Experimental Research, 26(6), 765–772.

    Article  Google Scholar 

  • Deitrich, R. A. (1993). Selective breeding for initial sensitivity to ethanol. Behavior Genetics, 23(2), 153–162.

    Article  CAS  PubMed  Google Scholar 

  • Dellu, F., Piazza, P. V., Mayo, W., Le Moal, M., & Simon, H. (1996). Novelty-seeking in rats—Biobehavioral characteristics and possible relationship with the sensation-seeking trait in man. Neuropsychobiology, 34(3), 136–145.

    Article  CAS  PubMed  Google Scholar 

  • Deminiere, J. M., Piazza, P. V., Le Moal, M., & Simon, H. (1989). Experimental approach to individual vulnerability to psychostimulant addiction. Neuroscience and Biobehavioral Reviews, 13(2–3), 141–147.

    Article  CAS  PubMed  Google Scholar 

  • Deroche, V., Piazza, P. V., Le Moal, M., & Simon, H. (1993). Individual differences in the psychomotor effects of morphine are predicted by reactivity to novelty and influenced by corticosterone secretion. Brain Research, 623(2), 341–344.

    Article  CAS  PubMed  Google Scholar 

  • Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004). Evidence for addiction-like behavior in the rat. Science, 305(5686), 1014–1017.

    Article  CAS  PubMed  Google Scholar 

  • Desor, J. A., & Beauchamp, G. K. (1987). Longitudinal changes in sweet preferences in humans. Physiology and Behavior, 39(5), 639–641.

    Article  CAS  PubMed  Google Scholar 

  • DeSousa, N. J., Bush, D. E., & Vaccarino, F. J. (2000). Self-administration of intravenous amphetamine is predicted by individual differences in sucrose feeding in rats. Psychopharmacology, 148(1), 52–58.

    Article  CAS  PubMed  Google Scholar 

  • Dess, N. K., Arnal, J., Chapman, C. D., Sidebel, S., VanderWeele, D. A., & Green, K. F. (2000). Exploring adaptations to famine: Rats selectively bred for differential intake of saccharin differ on deprivation-induced hyperactivity and emotionality. International Journal of Comparative Psychology, 13(1), 34–52.

    Google Scholar 

  • Dess, N. K., Badia-Elder, N. E., Thiele, T. E., Kiefer, S. W., & Blizard, D. A. (1998). Ethanol consumption in rats selectively bred for differential saccharin intake. Alcohol, 16(4), 275–278.

    Article  CAS  PubMed  Google Scholar 

  • Dess, N. K., & Minor, T. R. (1996). Taste and emotionality in rats selectively bred for high versus low saccharin intake. Learning and Behavior, 24, 105–115.

    Article  Google Scholar 

  • Diaz-Moran, S., Palencia, M., Mont-Cardona, C., Canete, T., Blazquez, G., Martinez-Membrives, E., et al. (2012). Coping style and stress hormone responses in genetically heterogeneous rats: Comparison with the Roman rat strains. Behavioural Brain Research, 228(1), 203–210.

    Article  CAS  PubMed  Google Scholar 

  • Diergaarde, L., Pattij, T., Nawijn, L., Schoffelmeer, A. N., & De Vries, T. J. (2009). Trait impulsivity predicts escalation of sucrose seeking and hypersensitivity to sucrose-associated stimuli. Behavioral Neuroscience, 123(4), 794–803.

    Article  CAS  PubMed  Google Scholar 

  • Dommett, E. J., & Rostron, C. L. (2013). Appetitive and consummative responding for liquid sucrose in the spontaneously hypertensive rat model of attention deficit hyperactivity disorder. Behavioural Brain Research, 238, 232–242.

    Article  CAS  PubMed  Google Scholar 

  • Eagle, D. M., Bari, A., & Robbins, T. W. (2008). The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks. Psychopharmacology, 199(3), 439–456.

    Article  CAS  PubMed  Google Scholar 

  • Ersche, K. D., Jones, P. S., Williams, G. B., Smith, D. G., Bullmore, E. T., & Robbins, T. W. (2012). Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence. Biological Psychiatry, 74(2), 137–144.

    Article  PubMed  Google Scholar 

  • Fagergren, P., Overstreet, D. H., Goiny, M., & Hurd, Y. L. (2005). Blunted response to cocaine in the Flinders hypercholinergic animal model of depression. Neuroscience, 132(4), 1159–1171.

    Article  CAS  PubMed  Google Scholar 

  • Fattore, L., Piras, G., Corda, M. G., & Giorgi, O. (2009). The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration. Neuropsychopharmacology, 34(5), 1091–1101.

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Teruel, A., Driscoll, P., Gil, L., Aguilar, R., Tobena, A., & Escorihuela, R. M. (2002). Enduring effects of environmental enrichment on novelty seeking, saccharin and ethanol intake in two rat lines (RHA/Verh and RLA/Verh) differing in incentive-seeking behavior. Pharmacology, Biochemistry, and Behavior, 73(1), 225–231.

    Article  CAS  PubMed  Google Scholar 

  • Ferreira, A., Lamarque, S., Boyer, P., Perez-Diaz, F., Jouvent, R., & Cohen-Salmon, C. (2006). Spontaneous appetence for wheel-running: A model of dependency on physical activity in rat. European Psychiatry, 21(8), 580–588.

    Article  PubMed  Google Scholar 

  • Flagel, S. B., Clark, J. J., Robinson, T. E., Mayo, L., Czuj, A., Willuhn, I., et al. (2011). A selective role for dopamine in stimulus-reward learning. Nature, 469(7328), 53–57.

    Article  CAS  PubMed  Google Scholar 

  • Flagel, S. B., Robinson, T. E., Clark, J. J., Clinton, S. M., Watson, S. J., Seeman, P., et al. (2010). An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology, 35(2), 388–400.

    Article  PubMed  Google Scholar 

  • Flagel, S. B., Watson, S. J., Akil, H., & Robinson, T. E. (2008). Individual differences in the attribution of incentive salience to a reward-related cue: Influence on cocaine sensitization. Behavioural Brain Research, 186(1), 48–56.

    Article  CAS  PubMed  Google Scholar 

  • Foroud, T., Ritchotte, A., Spence, J., Liu, L., Lumeng, L., Li, T. K., et al. (2003). Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. Psychiatric Genetics, 13(3), 155–161.

    Article  PubMed  Google Scholar 

  • Fox, A. T., Hand, D. J., & Reilly, M. P. (2008). Impulsive choice in a rodent model of attention-deficit/hyperactivity disorder. Behavioural Brain Research, 187(1), 146–152.

    Article  PubMed  Google Scholar 

  • Freeman, K. B., Kearns, D. N., Kohut, S. J., & Riley, A. L. (2009). Strain differences in patterns of drug-intake during prolonged access to cocaine self-administration. Behavioral Neuroscience, 123(1), 156–164.

    Article  CAS  PubMed  Google Scholar 

  • Froehlich, J. C. (2010). What aspects of human alcohol use disorders can be modeled using selectively bred rat lines? Substance Use and Misuse, 45(11), 1727–1741.

    Article  CAS  PubMed  Google Scholar 

  • Gahtan, E., Labounty, L. P., Wyvell, C., & Carroll, M. E. (1996). The relationships among saccharin consumption, oral ethanol, and i.v. cocaine self-administration. Pharmacology, Biochemistry, and Behavior, 53(4), 919–925.

    Article  CAS  PubMed  Google Scholar 

  • Gallaher, E. J., Hollister, L. E., Gionet, S. E., & Crabbe, J. C. (1987). Mouse lines selected for genetic differences in diazepam sensitivity. Psychopharmacology, 93(1), 25–30.

    Article  CAS  PubMed  Google Scholar 

  • Garbutt, J. C., Osborne, M., Gallop, R., Barkenbus, J., Grace, K., Cody, M., et al. (2009). Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence. Alcohol and Alcoholism (Oxford, Oxfordshire), 44(3), 293–300.

    Article  CAS  Google Scholar 

  • Garcia, A., & Kirkpatrick, K. (2012). Impulsive choice behavior in four strains of rats: Evaluation of possible models of Attention-Deficit/Hyperactivity Disorder. Behavioural Brain Research, 238, 10–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Garcia-Lecumberri, C., Torres, I., Martin, S., Crespo, J. A., Miguens, M., Nicanor, C., et al. (2011). Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats. Journal of Psychopharmacology, 25(6), 783–791.

    Article  CAS  PubMed  Google Scholar 

  • Gingras, M. A., & Cools, A. R. (1996). Analysis of the biphasic locomotor response to ethanol in high and low responders to novelty: A study in Nijmegen Wistar rats. Psychopharmacology, 125(3), 258–264.

    Article  CAS  PubMed  Google Scholar 

  • Giorgi, O., Corda, M. G., Carboni, G., Frau, V., Valentini, V., & Di Chiara, G. (1997). Effects of cocaine and morphine in rats from two psychogenetically selected lines: A behavioral and brain dialysis study. Behavior Genetics, 27(6), 537–546.

    Article  CAS  PubMed  Google Scholar 

  • Giorgi, O., Piras, G., Lecca, D., & Corda, M. G. (2005). Behavioural effects of acute and repeated cocaine treatments: A comparative study in sensitisation-prone RHA rats and their sensitisation-resistant RLA counterparts. Psychopharmacology, 180(3), 530–538.

    Article  CAS  PubMed  Google Scholar 

  • Godfrey, C. D., Froehlich, J. C., Stewart, R. B., Li, T. K., & Murphy, J. M. (1997). Comparison of rats selectively bred for high and low ethanol intake in a forced-swim-test model of depression: Effects of desipramine. Physiology and Behavior, 62(4), 729–733.

    Article  CAS  PubMed  Google Scholar 

  • Gordon, T. L., Meehan, S. M., & Schechter, M. D. (1993). Differential effects of nicotine but not cathinone on motor activity of P and NP rats. Pharmacology, Biochemistry, and Behavior, 44(3), 657–659.

    Article  CAS  PubMed  Google Scholar 

  • Gosnell, B. A. (2000). Sucrose intake predicts rate of acquisition of cocaine self-administration. Psychopharmacology, 149(3), 286–292.

    Article  CAS  PubMed  Google Scholar 

  • Gosnell, B. A., Krahn, D. D., Yracheta, J. M., & Harasha, B. J. (1998). The relationship between intravenous cocaine self-administration and avidity for saccharin. Pharmacology, Biochemistry, and Behavior, 60(1), 229–236.

    Article  CAS  PubMed  Google Scholar 

  • Gosnell, B. A., Lane, K. E., Bell, S. M., & Krahn, D. D. (1995). Intravenous morphine self-administration by rats with low versus high saccharin preferences. Psychopharmacology, 117(2), 248–252.

    Article  CAS  PubMed  Google Scholar 

  • Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. The American Journal of Psychiatry, 160(4), 636–645.

    Article  PubMed  Google Scholar 

  • Guitart-Masip, M., Gimenez-Llort, L., Fernandez-Teruel, A., Canete, T., Tobena, A., Ogren, S. O., et al. (2006). Reduced ethanol response in the alcohol-preferring RHA rats and neuropeptide mRNAs in relevant structures. European Journal of Neuroscience, 23(2), 531–540.

    Article  PubMed  Google Scholar 

  • Hall, F. S., Fong, G. W., Ghaed, S., & Pert, A. (2001). Locomotor-stimulating effects of indirect dopamine agonists are attenuated in Fawn hooded rats independent of postweaning social experience. Pharmacology, Biochemistry, and Behavior, 69(3–4), 519–526.

    Article  CAS  PubMed  Google Scholar 

  • Hall, F. S., Markou, A., Levin, E. D., & Uhl, G. R. (2012). Mouse models for studying genetic influences on factors determining smoking cessation success in humans. Annals of the New York Academy of Sciences, 1248, 39–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Haney, M., Castanon, N., Cador, M., Le Moal, M., & Mormede, P. (1994). Cocaine sensitivity in Roman High and Low Avoidance rats is modulated by sex and gonadal hormone status. Brain Research, 645(1–2), 179–185.

    Article  CAS  PubMed  Google Scholar 

  • He, S., Yang, Y., Mathur, D., & Grasing, K. (2008). Selective breeding for intravenous drug self-administration in rats: A pilot study. Behavioural Pharmacology, 19(8), 751–764.

    Article  CAS  PubMed  Google Scholar 

  • Higgins, S. T. (2003). An historical note on Darwin and nonhuman drug self-administration. Experimental and Clinical Psychopharmacology, 11(4), 317.

    Article  PubMed  Google Scholar 

  • Hinojosa, F. R., Spricigo, L., Jr., Izidio, G. S., Bruske, G. R., Lopes, D. M., & Ramos, A. (2006). Evaluation of two genetic animal models in behavioral tests of anxiety and depression. Behavioural Brain Research, 168(1), 127–136.

    Article  PubMed  Google Scholar 

  • Holtz, N. A., & Carroll, M. E. (2011). Baclofen has opposite effects on escalation of cocaine self-administration: increased intake in rats selectively bred for high (HiS) saccharin intake and decreased intake in those selected for low (LoS) saccharin intake. Pharmacology, Biochemistry, and Behavior, 100(2), 275–283.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holtz, N. A., & Carroll, M. E. (2013). Escalation of i.v. cocaine intake in peri-adolescent vs. adult rats selectively bred for high (HiS) vs. low (LoS) saccharin intake. Psychopharmacology, 227(2), 243–250.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holtz, N. A., Radke, A. C., Gewirtz, J. C., & Carroll, M. E. (In preparation). Morphine-induced potentiation of the acoustic startle reflex and conditioned place aversion in Lewis (LEW) and Fischer (F344) rats.

    Google Scholar 

  • Hooks, M. S., Jones, G. H., Smith, A. D., Neill, D. B., & Justice, J. B., Jr. (1991). Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse, 9(2), 121–128.

    Article  CAS  PubMed  Google Scholar 

  • Howard, M. O., Kivlahan, D., & Walker, R. D. (1997). Cloninger’s tridimensional theory of personality and psychopathology: Applications to substance use disorders. Journal of Studies on Alcohol, 58(1), 48–66.

    Article  CAS  PubMed  Google Scholar 

  • Huskinson, S. L., Krebs, C. A., & Anderson, K. G. (2010). Strain differences in delay discounting between Lewis and Fischer 344 rats at baseline and following acute and chronic administration of d-amphetamine. Pharmacology, Biochemistry, and Behavior, 101(3), 403–416.

    Article  CAS  Google Scholar 

  • Izidio, G. S., & Ramos, A. (2007). Positive association between ethanol consumption and anxiety-related behaviors in two selected rat lines. Alcohol, 41(7), 517–524.

    Article  CAS  PubMed  Google Scholar 

  • Jama, A., Cecchi, M., Calvo, N., Watson, S. J., & Akil, H. (2008). Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test. Psychopharmacology, 198(3), 333–340.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Janowsky, D. S., Pucilowski, O., & Buyinza, M. (2003). Preference for higher sucrose concentrations in cocaine abusing-dependent patients. Journal of Psychiatric Research, 37(1), 35–41.

    Article  PubMed  Google Scholar 

  • Jupp, B., Caprioli, D., & Dalley, J. W. (2013). Highly impulsive rats: Modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction. Disease Models & Mechanisms, 6(2), 302–311.

    Article  CAS  Google Scholar 

  • Kabbaj, M. (2006). Individual differences in vulnerability to drug abuse: The high responders/low responders model. CNS & Neurological Disorders Drug Targets, 5(5), 513–520.

    Article  Google Scholar 

  • Kampov-Polevoy, A. B., Garbutt, J. C., Davis, C. E., & Janowsky, D. S. (1998). Preference for higher sugar concentrations and Tridimensional Personality Questionnaire scores in alcoholic and nonalcoholic men. Alcoholism: Clinical and Experimental Research, 22(3), 610–614.

    Article  CAS  Google Scholar 

  • Kampov-Polevoy, A., Garbutt, J. C., & Janowsky, D. (1997). Evidence of preference for a high-concentration sucrose solution in alcoholic men. The American Journal of Psychiatry, 154(2), 269–270.

    Article  CAS  PubMed  Google Scholar 

  • Kampov-Polevoy, A. B., Tsoi, M. V., Zvartau, E. E., Neznanov, N. G., & Khalitov, E. (2001). Sweet liking and family history of alcoholism in hospitalized alcoholic and non-alcoholic patients. Alcohol and Alcoholism (Oxford, Oxfordshire), 36(2), 165–170.

    Article  CAS  Google Scholar 

  • Kearns, D. N., Gomez-Serrano, M. A., Weiss, S. J., & Riley, A. L. (2006). A comparison of Lewis and Fischer rat strains on autoshaping (sign-tracking), discrimination reversal learning and negative auto-maintenance. Behavioural Brain Research, 169(2), 193–200.

    Article  PubMed  Google Scholar 

  • Keskitalo, K., Knaapila, A., Kallela, M., Palotie, A., Wessman, M., Sammalisto, S., et al. (2007a). Sweet taste preferences are partly genetically determined: Identification of a trait locus on chromosome 16. American Journal of Clinical Nutrition, 86(1), 55–63.

    CAS  PubMed  Google Scholar 

  • Keskitalo, K., Tuorila, H., Spector, T. D., Cherkas, L. F., Knaapila, A., Silventoinen, K., et al. (2007b). Same genetic components underlie different measures of sweet taste preference. American Journal of Clinical Nutrition, 86(6), 1663–1669.

    CAS  PubMed  Google Scholar 

  • Keskitalo, K., Tuorila, H., Spector, T. D., Cherkas, L. F., Knaapila, A., Kaprio, J., et al. (2008). The three-factor eating questionnaire, body mass index, and responses to sweet and salty fatty foods: A twin study of genetic and environmental associations. American Journal of Clinical Nutrition, 88(2), 263–271.

    CAS  PubMed  Google Scholar 

  • Khanna, J. M., Kalant, H., Chau, A. K., & Sharma, H. (1990). Initial sensitivity, acute tolerance and alcohol consumption in four inbred strains of rats. Psychopharmacology, 101(3), 390–395.

    Article  CAS  PubMed  Google Scholar 

  • Kiianmaa, K., Stenius, K., & Sinclair, J. D. (1991). Determinants of alcohol preference in the AA and ANA rat lines selected for differential ethanol intake. Alcohol and Alcoholism. Supplement, 1, 115–120.

    CAS  Google Scholar 

  • Kingwell, B. A., Arnold, P. J., Jennings, G. L., & Dart, A. M. (1998). The effects of voluntary running on cardiac mass and aortic compliance in Wistar-Kyoto and spontaneously hypertensive rats. Journal of Hypertension, 16(2), 181–185.

    Article  CAS  PubMed  Google Scholar 

  • Klebaur, J. E., Bevins, R. A., Segar, T. M., & Bardo, M. T. (2001). Individual differences in behavioral responses to novelty and amphetamine self-administration in male and female rats. Behavioural Pharmacology, 12(4), 267–275.

    Article  CAS  PubMed  Google Scholar 

  • Kosten, T. A., & Ambrosio, E. (2002). HPA axis function and drug addictive behaviors: Insights from studies with Lewis and Fischer 344 inbred rats. Psychoneuroendocrinology, 27(1–2), 35–69.

    Article  CAS  PubMed  Google Scholar 

  • Kosten, T. A., Zhang, X. Y., & Haile, C. N. (2007). Strain differences in maintenance of cocaine self-administration and their relationship to novelty activity responses. Behavioral Neuroscience, 121(2), 380–388.

    Article  CAS  PubMed  Google Scholar 

  • Kruzich, P. J., & Xi, J. (2006a). Differences in extinction responding and reinstatement of methamphetamine-seeking behavior between Fischer 344 and Lewis rats. Pharmacology, Biochemistry, and Behavior, 83(3), 391–395.

    Article  CAS  PubMed  Google Scholar 

  • Kruzich, P. J., & Xi, J. (2006b). Different patterns of pharmacological reinstatement of cocaine-seeking behavior between Fischer 344 and Lewis rats. Psychopharmacology, 187(1), 22–29.

    Article  CAS  PubMed  Google Scholar 

  • Laaksonen, E., Lahti, J., Sinclair, J. D., Heinala, P., & Alho, H. (2011). Predictors for the efficacy of naltrexone treatment in alcohol dependence: Sweet preference. Alcohol and Alcoholism (Oxford, Oxfordshire), 46(3), 308–311.

    Article  CAS  Google Scholar 

  • Lange, L. A., Kampov-Polevoy, A. B., & Garbutt, J. C. (2010). Sweet liking and high novelty seeking: Independent phenotypes associated with alcohol-related problems. Alcohol and Alcoholism (Oxford, Oxfordshire), 45(5), 431–436.

    Article  Google Scholar 

  • Larson, E. B., & Carroll, M. E. (2005). Wheel running as a predictor of cocaine self-administration and reinstatement in female rats. Pharmacology, Biochemistry, and Behavior, 82(3), 590–600.

    Article  CAS  PubMed  Google Scholar 

  • Laudet, A. B., Stanick, V., & Sands, B. (2009). What could the program have done differently? A qualitative examination of reasons for leaving outpatient treatment. Journal of Substance Abuse Treatment, 37(2), 182–190.

    Article  PubMed  PubMed Central  Google Scholar 

  • Le Foll, B., Gallo, A., Le Strat, Y., Lu, L., & Gorwood, P. (2009). Genetics of dopamine receptors and drug addiction: A comprehensive review. Behavioural Pharmacology, 20(1), 1–17.

    Article  PubMed  CAS  Google Scholar 

  • Le, A. D., Li, Z., Funk, D., Shram, M., Li, T. K., & Shaham, Y. (2006). Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake. Journal of Neuroscience, 26(6), 1872–1879.

    Article  CAS  PubMed  Google Scholar 

  • Lecca, D., Piras, G., Driscoll, P., Giorgi, O., & Corda, M. G. (2004). A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: A brain dialysis study in Roman high- and low-avoidance rats. Neuropharmacology, 46(5), 688–699.

    Article  CAS  PubMed  Google Scholar 

  • Li, T. K., Lumeng, L., McBride, W. J., & Murphy, J. M. (1994). Genetic and neurobiological basis of alcohol-seeking behavior. Alcohol and Alcoholism (Oxford, Oxfordshire), 29(6), 697–700.

    CAS  Google Scholar 

  • Li, T. K., Lumeng, L., & Doolittle, D. P. (1993). Selective breeding for alcohol preference and associated responses. Behavior Genetics, 23(2), 163–170.

    Article  CAS  PubMed  Google Scholar 

  • Lin, S. J., Epps, S. A., West, C. H., Boss-Williams, K. A., Weiss, J. M., & Weinshenker, D. (2012). Operant psychostimulant self-administration in a rat model of depression. Pharmacology, Biochemistry, and Behavior, 103(2), 380–385.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lodge, D. J., & Lawrence, A. J. (2003). Comparative analysis of hepatic ethanol metabolism in Fawn-Hooded and Wistar-Kyoto rats. Alcohol, 30(1), 75–79.

    Article  CAS  PubMed  Google Scholar 

  • Lovic, V., Saunders, B. T., Yager, L. M., & Robinson, T. E. (2011). Rats prone to attribute incentive salience to reward cues are also prone to impulsive action. Behavioural Brain Research, 223(2), 255–261.

    Article  PubMed  PubMed Central  Google Scholar 

  • MacKillop, J. (2013). Integrating behavioral economics and behavioral genetics: Delayed reward discounting as an endophenotype for addictive disorders. Journal of the Experimental Analysis of Behavior, 99(1), 14–31.

    Article  PubMed  Google Scholar 

  • MacKillop, J., & Kahler, C. W. (2009). Delayed reward discounting predicts treatment response for heavy drinkers receiving smoking cessation treatment. Drug and Alcohol Dependence, 104(3), 197–203.

    Article  PubMed  PubMed Central  Google Scholar 

  • Madden, G. J., Smith, N. G., Brewer, A. T., Pinkston, J. W., & Johnson, P. S. (2008). Steady-state assessment of impulsive choice in Lewis and Fischer 344 rats: Between-condition delay manipulations. Journal of the Experimental Analysis of Behavior, 90(3), 333–344.

    Article  PubMed  PubMed Central  Google Scholar 

  • Manzo, L., Gomez, M. J., Callejas-Aguilera, J. E., Fernandez-Teruel, A., Papini, M. R., & Torres, C. (2012). Oral ethanol self-administration in inbred Roman high- and low-avoidance rats: Gradual versus abrupt ethanol presentation. Physiology and Behavior, 108, 1–5.

    Article  CAS  PubMed  Google Scholar 

  • Marti, J., & Armario, A. (1996). Forced swimming behavior is not related to the corticosterone levels achieved in the test: A study with four inbred rat strains. Physiology and Behavior, 59(2), 369–373.

    Article  CAS  PubMed  Google Scholar 

  • Marusich, J. A., Darna, M., Charnigo, R. J., Dwoskin, L. P., & Bardo, M. T. (2011a). A multivariate assessment of individual differences in sensation seeking and impulsivity as predictors of amphetamine self-administration and prefrontal dopamine function in rats. Experimental and Clinical Psychopharmacology, 19(4), 275–284.

    Article  PubMed  PubMed Central  Google Scholar 

  • Marusich, J. A., McCuddy, W. T., Beckmann, J. S., Gipson, C. D., & Bardo, M. T. (2011b). Strain differences in self-administration of methylphenidate and sucrose pellets in a rat model of attention-deficit hyperactivity disorder. Behavioural Pharmacology, 22(8), 794–804.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McBride, W. J., & Li, T. K. (1998). Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents. Critical Reviews in Neurobiology, 12(4), 339–369.

    Article  CAS  PubMed  Google Scholar 

  • Meneses, A., Perez-Garcia, G., Ponce-Lopez, T., Tellez, R., Gallegos-Cari, A., & Castillo, C. (2011). Spontaneously hypertensive rat (SHR) as an animal model for ADHD: A short overview. Reviews in the Neurosciences, 22(3), 365–371.

    Article  CAS  PubMed  Google Scholar 

  • Merikangas, K. R., & Risch, N. (2003). Genomic priorities and public health. Science, 302(5645), 599–601.

    Article  CAS  PubMed  Google Scholar 

  • Miguens, M., Botreau, F., Olias, O., Del Olmo, N., Coria, S. M., Higuera-Matas, A., et al. (2011). Genetic differences in the modulation of accumbal glutamate and gamma-amino butyric acid levels after cocaine-induced reinstatement. Addiction Biology, 18(4), 623–632.

    Article  PubMed  CAS  Google Scholar 

  • Mikrouli, E., Wortwein, G., Soylu, R., Mathe, A. A., & Petersen, A. (2011). Increased numbers of orexin/hypocretin neurons in a genetic rat depression model. Neuropeptides, 45(6), 401–406.

    Article  CAS  PubMed  Google Scholar 

  • Miserendino, M. J., Haile, C. N., & Kosten, T. A. (2003). Strain differences in response to escapable and inescapable novel environments and their ability to predict amphetamine-induced locomotor activity. Psychopharmacology, 167(3), 281–290.

    CAS  PubMed  Google Scholar 

  • Molander, A. C., Mar, A., Norbury, A., Steventon, S., Moreno, M., Caprioli, D., et al. (2011). High impulsivity predicting vulnerability to cocaine addiction in rats: Some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology, 215(4), 721–731.

    Article  CAS  PubMed  Google Scholar 

  • Moreno, M., Cardona, D., Gomez, M. J., Sanchez-Santed, F., Tobena, A., Fernandez-Teruel, A., et al. (2010). Impulsivity characterization in the Roman high- and low-avoidance rat strains: Behavioral and neurochemical differences. Neuropsychopharmacology, 35(5), 1198–1208.

    Article  PubMed  PubMed Central  Google Scholar 

  • Murphy, S. B., Reinarman, C., & Waldorf, D. (1989). An 11-year follow-up of a network of cocaine users. British Journal of Addiction, 84(4), 427–436.

    Article  CAS  PubMed  Google Scholar 

  • Nichols, J. R., & Hsiao, S. (1967). Addiction liability of albino rats: Breeding for quantitative differences in morphine drinking. Science, 157(3788), 561–563.

    Article  CAS  PubMed  Google Scholar 

  • Olsen, C. M. (2011). Natural rewards, neuroplasticity, and non-drug addictions. Neuropharmacology, 61(7), 1109–1122.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Overstreet, D. H., & Djuric, V. (2001). A genetic rat model of cholinergic hypersensitivity: Implications for chemical intolerance, chronic fatigue, and asthma. Annals of the New York Academy of Sciences, 933, 92–102.

    Article  CAS  PubMed  Google Scholar 

  • Overstreet, D. H., Friedman, E., Mathe, A. A., & Yadid, G. (2005). The Flinders Sensitive Line rat: A selectively bred putative animal model of depression. Neuroscience and Biobehavioral Reviews, 29(4–5), 739–759.

    Article  CAS  PubMed  Google Scholar 

  • Overstreet, D. H., Kampov-Polevoy, A. B., Rezvani, A. H., Murrelle, L., Halikas, J. A., & Janowsky, D. S. (1993). Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcoholism: Clinical and Experimental Research, 17(2), 366–369.

    Article  CAS  Google Scholar 

  • Overstreet, D. H., & Wegener, G. (2013). The flinders sensitive line rat model of depression—25 years and still producing. Pharmacological Reviews, 65(1), 143–155.

    Article  CAS  PubMed  Google Scholar 

  • Pepino, M. Y., & Mennella, J. A. (2007). Effects of cigarette smoking and family history of alcoholism on sweet taste perception and food cravings in women. Alcoholism: Clinical and Experimental Research, 31(11), 1891–1899.

    Article  Google Scholar 

  • Perry, J. L., Anderson, M. M., Nelson, S. E., & Carroll, M. E. (2007a). Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Physiology and Behavior, 91(1), 126–133.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perry, J. L., Nelson, S. E., Anderson, M. M., Morgan, A. D., & Carroll, M. E. (2007b). Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. Pharmacology, Biochemistry, and Behavior, 86(4), 822–837.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perry, J. L., & Carroll, M. E. (2008). The role of impulsive behavior in drug abuse. Psychopharmacology, 200(1), 1–26.

    Article  CAS  PubMed  Google Scholar 

  • Perry, J. L., Morgan, A. D., Anker, J. J., Dess, N. K., & Carroll, M. E. (2006). Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake. Psychopharmacology, 186(2), 235–245.

    Article  CAS  PubMed  Google Scholar 

  • Perry, J. L., Nelson, S. E., & Carroll, M. E. (2008). Impulsive choice as a predictor of acquisition of IV cocaine self- administration and reinstatement of cocaine-seeking behavior in male and female rats. Experimental and Clinical Psychopharmacology, 16(2), 165–177.

    Article  PubMed  Google Scholar 

  • Pettinati, H. M., O’Brien, C. P., & Dundon, W. D. (2013). Current status of co-occurring mood and substance use disorders: A new therapeutic target. The American Journal of Psychiatry, 170(1), 23–30.

    Article  PubMed  PubMed Central  Google Scholar 

  • Piazza, P. V., Deminiere, J. M., Le Moal, M., & Simon, H. (1989). Factors that predict individual vulnerability to amphetamine self-administration. Science, 245(4925), 1511–1513.

    Article  CAS  PubMed  Google Scholar 

  • Picetti, R., Caccavo, J. A., Ho, A., & Kreek, M. J. (2012). Dose escalation and dose preference in extended-access heroin self-administration in Lewis and Fischer rats. Psychopharmacology, 220(1), 163–172.

    Article  CAS  PubMed  Google Scholar 

  • Picetti, R., Ho, A., Butelman, E. R., & Kreek, M. J. (2010). Dose preference and dose escalation in extended-access cocaine self-administration in Fischer and Lewis rats. Psychopharmacology, 211(3), 313–323.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pike, E., Stoops, W. W., Fillmore, M. T., & Rush, C. R. (2011). Drug-related stimuli impair inhibitory control in cocaine abusers. Drug and Alcohol Dependence, 133(2), 768–771.

    Article  Google Scholar 

  • Piras, G., Giorgi, O., & Corda, M. G. (2010). Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions. Psychopharmacology, 211(4), 403–414.

    Article  CAS  PubMed  Google Scholar 

  • Piras, G., Lecca, D., Corda, M. G., & Giorgi, O. (2003). Repeated morphine injections induce behavioural sensitization in Roman high- but not in Roman low-avoidance rats. Neuroreport, 14(18), 2433–2438.

    Article  CAS  PubMed  Google Scholar 

  • Pisula, W. (2003). The Roman high- and low-avoidance rats respond differently to novelty in a familiarized environment. Behavioural Processes, 63(2), 63–72.

    Article  PubMed  Google Scholar 

  • Pomerleau, O. F. (1995). Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence. Behavior Genetics, 25(2), 161–177.

    Article  CAS  PubMed  Google Scholar 

  • Pomerleau, C. S., Garcia, A. W., Drewnowski, A., & Pomerleau, O. F. (1991). Sweet taste preference in women smokers: Comparison with nonsmokers and effects of menstrual phase and nicotine abstinence. Pharmacology, Biochemistry, and Behavior, 40(4), 995–999.

    Article  CAS  PubMed  Google Scholar 

  • Pucilowski, O., Overstreet, D. H., Rezvani, A. H., & Janowsky, D. S. (1993). Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression. Physiology and Behavior, 54(6), 1215–1220.

    Article  CAS  PubMed  Google Scholar 

  • Reed, D. R., Bachmanov, A. A., Beauchamp, G. K., Tordoff, M. G., & Price, R. A. (1997). Heritable variation in food preferences and their contribution to obesity. Behavior Genetics, 27(4), 373–387.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rezvani, A. H., Parsian, A., & Overstreet, D. H. (2002). The Fawn-Hooded (FH/Wjd) rat: A genetic animal model of comorbid depression and alcoholism. Psychiatric Genetics, 12(1), 1–16.

    Article  PubMed  Google Scholar 

  • Riley, E. P., Worsham, E. D., Lester, D., & Freed, E. X. (1977). Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. II. Behavioral measures. Journal of Studies on Alcohol, 38(9), 1705–1717.

    Article  CAS  PubMed  Google Scholar 

  • Robinson, E. S., Eagle, D. M., Economidou, D., Theobald, D. E., Mar, A. C., Murphy, E. R., et al. (2009). Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: Specific deficits in ‘waiting’ versus ‘stopping’. Behavioural Brain Research, 196(2), 310–316.

    Article  CAS  PubMed  Google Scholar 

  • Roman, E., Stewart, R. B., Bertholomey, M. L., Jensen, M. L., Colombo, G., Hyytia, P., et al. (2012). Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test. Addiction Biology, 17(1), 33–46.

    Article  CAS  PubMed  Google Scholar 

  • Roth-Deri, I., Friedman, A., Abraham, L., Lax, E., Flaumenhaft, Y., Dikshtein, Y., et al. (2009). Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression. European Journal of Neuroscience, 30(3), 485–492.

    Article  PubMed  Google Scholar 

  • Sagvolden, T., Johansen, E. B., Woien, G., Walaas, S. I., Storm-Mathisen, J., Bergersen, L. H., et al. (2009). The spontaneously hypertensive rat model of ADHD—The importance of selecting the appropriate reference strain. Neuropharmacology, 57(7–8), 619–626.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saunders, B. T., & Robinson, T. E. (2011). Individual variation in the motivational properties of cocaine. Neuropsychopharmacology, 36(8), 1668–1676.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saunders, B. T., Yager, L. M., & Robinson, T. E. (2013). Cue-evoked cocaine “craving”: Role of dopamine in the accumbens core. Journal of Neuroscience, 33(35), 13989–14000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shiffman, S. (1989). Tobacco “chippers”—Individual differences in tobacco dependence. Psychopharmacology, 97(4), 539–547.

    Article  CAS  PubMed  Google Scholar 

  • Sinclair, J. D., Kampov-Polevoy, A., Stewart, R., & Li, T. K. (1992). Taste preferences in rat lines selected for low and high alcohol consumption. Alcohol, 9(2), 155–160.

    Article  CAS  PubMed  Google Scholar 

  • Sinha, R. (2011). New findings on biological factors predicting addiction relapse vulnerability. Current Psychiatry Reports, 13(5), 398–405.

    Article  PubMed  PubMed Central  Google Scholar 

  • Smolen, A., Marks, M. J., DeFries, J. C., & Henderson, N. D. (1994). Individual differences in sensitivity to nicotine in mice: Response to six generations of selective breeding. Pharmacology, Biochemistry, and Behavior, 49(3), 531–540.

    Article  CAS  PubMed  Google Scholar 

  • Stark, M. J. (1992). Dropping out of substance-abuse treatment—A clinically oriented review. Clinical Psychology Review, 12(1), 93–116.

    Article  Google Scholar 

  • Stewart, R. B., Russell, R. N., Lumeng, L., Li, T. K., & Murphy, J. M. (1994). Consumption of sweet, salty, sour, and bitter solutions by selectively bred alcohol-preferring and alcohol-nonpreferring lines of rats. Alcoholism: Clinical and Experimental Research, 18(2), 375–381.

    Article  CAS  Google Scholar 

  • Suzuki, T., George, F. R., & Meisch, R. A. (1988). Differential establishment and maintenance of oral ethanol reinforced behavior in Lewis and Fischer 344 inbred rat strains. Journal of Pharmacology and Experimental Therapeutics, 245(1), 164–170.

    CAS  PubMed  Google Scholar 

  • Swendsen, J., & Le Moal, M. (2011). Individual vulnerability to addiction. Annals of the New York Academy of Sciences, 1216, 73–85.

    Article  PubMed  Google Scholar 

  • Tomie, A., Aguado, A. S., Pohorecky, L. A., & Benjamin, D. (1998). Ethanol induces impulsive-like responding in a delay-of-reward operant choice procedure: Impulsivity predicts autoshaping. Psychopharmacology, 139(4), 376–382.

    Article  CAS  PubMed  Google Scholar 

  • Tomie, A., Brooks, W., & Zito, B. (1989). Sign-tracking: The search for reward. In S. B. Klein & R. R. Mowrer (Eds.), Pavlovian conditioning and the status of traditional learning theory (pp. 191–223). Hillsdale, NJ: Erlbaum.

    Google Scholar 

  • Tomie, A., Grimes, K. L., & Pohorecky, L. A. (2008). Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse. Brain Research Reviews, 58(1), 121–135.

    Article  CAS  PubMed  Google Scholar 

  • Tordoff, M. G., Alarcon, L. K., & Lawler, M. P. (2008). Preferences of 14 rat strains for 17 taste compounds. Physiology and Behavior, 95(3), 308–332.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tzilos, G. K., Rhodes, G. L., Ledgerwood, D. M., & Greenwald, M. K. (2009). Predicting cocaine group treatment outcome in cocaine-abusing methadone patients. Experimental and Clinical Psychopharmacology, 17(5), 320–325.

    Article  PubMed  Google Scholar 

  • Uhl, G. R., Drgon, T., Johnson, C., & Liu, Q. R. (2009). Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. Journal of Neurogenetics, 23(3), 272–282.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • van den Bergh, F. S., Bloemarts, E., Chan, J. S., Groenink, L., Olivier, B., & Oosting, R. S. (2006). Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder. Pharmacology, Biochemistry, and Behavior, 83(3), 380–390.

    Article  PubMed  CAS  Google Scholar 

  • Vendruscolo, L. F., Izidio, G. S., & Takahashi, R. N. (2009). Drug reinforcement in a rat model of attention deficit/hyperactivity disorder—The Spontaneously Hypertensive Rat (SHR). Current Drug Abuse Reviews, 2(2), 177–183.

    Article  CAS  PubMed  Google Scholar 

  • Weiss, G. (1982). Food fantasies of incarcerated drug users. International Journal of the Addictions, 17(5), 905–912.

    Article  CAS  PubMed  Google Scholar 

  • Weiss, J. M., Cierpial, M. A., & West, C. H. (1998). Selective breeding of rats for high and low motor activity in a swim test: Toward a new animal model of depression. Pharmacology, Biochemistry, and Behavior, 61(1), 49–66.

    Article  CAS  PubMed  Google Scholar 

  • Weiss, J. M., West, C. H., Emery, M. S., Bonsall, R. W., Moore, J. P., & Boss-Williams, K. A. (2008). Rats selectively-bred for behavior related to affective disorders: Proclivity for intake of alcohol and drugs of abuse, and measures of brain monoamines. Biochemical Pharmacology, 75(1), 134–159.

    Article  CAS  PubMed  Google Scholar 

  • Werme, M., Thoren, P., Olson, L., & Brene, S. (2000). Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen. European Journal of Neuroscience, 12(8), 2967–2974.

    Article  CAS  PubMed  Google Scholar 

  • West, C. H., & Weiss, J. M. (2006). Intake of ethanol and reinforcing fluids in rats bred for susceptibility to stress. Alcohol, 38(1), 13–27.

    Article  CAS  PubMed  Google Scholar 

  • Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C. L., Janowsky, A., et al. (2009). Genetically correlated effects of selective breeding for high and low methamphetamine consumption. Genes, Brain and Behavior, 8(8), 758–771.

    Article  CAS  Google Scholar 

  • White, D. A., Kalinichev, M., & Holtzman, S. G. (2007). Locomotor response to novelty as a predictor of reactivity to aversive stimuli in the rat. Brain Research, 1149, 141–148.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wilhelm, C. J., & Mitchell, S. H. (2008). Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes. Genes, Brain and Behavior, 7(7), 705–713.

    Article  CAS  Google Scholar 

  • Wronski, M., Skrok-Wolska, D., Samochowiec, J., Ziolkowski, M., Swiecicki, L., Bienkowski, P., et al. (2007). Perceived intensity and pleasantness of sucrose taste in male alcoholics. Alcohol and Alcoholism (Oxford, Oxfordshire), 42(2), 75–79.

    Article  Google Scholar 

  • Yerkes, R. M., & Dodson, J. D. (1908). The relation of strength of stimulus to rapidity of habit-formation. Journal of Comparative Neurology and Psychology, 18, 459–482.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, University of Washington, 1959 NE Pacific, Box 356560, Seattle, WA, 98915, USA

    Nathan A. Holtz Ph.D.

  2. Department of Psychiatry, University of Minnesota, 2450 Riverside Ave. S., Minneapolis, MN, 55454, USA

    Marilyn E. Carroll

Authors
  1. Nathan A. Holtz Ph.D.
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  2. Marilyn E. Carroll
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Correspondence to Marilyn E. Carroll .

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Editors and Affiliations

  1. Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA

    Jonathan C. Gewirtz

  2. Janelia Research Campus, Howard Hughes Medical Institue, Ashburn, Virginia, USA

    Yong-Kyu Kim

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Holtz, N.A., Carroll, M.E. (2016). Animal Models of Addiction: Genetic Influences. In: Gewirtz, J., Kim, YK. (eds) Animal Models of Behavior Genetics. Advances in Behavior Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3777-6_10

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