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Mitochondrial Mutagenesis in Cancer

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Book cover Mitochondria and Cell Death

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

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Abstract

Recent studies have implicated mitochondrial DNA mutations in tumor progression. In this chapter, we provide a review of the studies reporting on mitochondrial DNA mutations and their possible contributions to carcinogenesis. We propose a revised, practical definition for mitochondrial sequence diversity that accounts for observed thresholds found in mutation detection technologies and mitochondrial pathophysiology. Additionally, we describe current and prior efforts to identify somatic mutations in cancer and the challenges unique to mitochondrial DNA mutation analysis. We discuss the mechanisms that may generate these mutations, as well as the spectrum of observed physiological changes in cancer which they produce. Finally, we consider the utility of mitochondrial mutations as a sensitive biomarker in cancer diagnosis, disease prognosis, and patient outcomes.

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  1. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    William J. Valente & Jason H. Bielas

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  1. William J. Valente
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Correspondence to Jason H. Bielas .

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  1. Clinical Research Divison, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    David M. Hockenbery

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Valente, W.J., Bielas, J.H. (2016). Mitochondrial Mutagenesis in Cancer. In: Hockenbery, D. (eds) Mitochondria and Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3612-0_7

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