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Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program

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Cancer Epigenetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1238))

Abstract

This chapter describes resources and technologies generated by the NIH Roadmap Epigenomics Program that may be useful to epigenomics researchers investigating a variety of diseases including cancer. Highlights include reference epigenome maps for a wide variety of human cells and tissues, the development of new technologies for epigenetic assays and imaging, the identification of novel epigenetic modifications, and an improved understanding of the role of epigenetic processes in a diversity of human diseases. We also discuss future needs in this area including exploration of epigenomic variation between individuals, single-cell epigenomics, environmental epigenomics, exploration of the use of surrogate tissues, and improved technologies for epigenome manipulation.

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Acknowledgements

The views expressed in this chapter are solely those of the authors and may not necessarily reflect those of NIH. The authors would like to thank all of the researchers associated with the NIH Roadmap Epigenomics Program for their tireless efforts to help transform this scientific field. We thank NIH senior leadership for their vision in selecting Epigenomics as a Common Fund program, especially Nora Volkow (NIDA), Linda Birnbaum (NIEHS), and James Battey (NIDCD). We thank the Common Fund Office of Science Coordination for financial support and encouragement. We thank the NIH Epigenomics Work Group members for their efforts and support during the development of this program. We especially thank Olivier Blondel, Mark Caulder, Christine Colvis, Stephanie Courchesne, Elise Feingold, Michelle Freund, Astrid Haugen, Tanya Hoodbhoy, Patricia Labosky, Roger Little, Pat Mastin, Michael Pazin, Phil Smith, Randall Stewart, and Elizabeth Wilder for their efforts in helping implement this program.

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Authors and Affiliations

  1. Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, NIH, MSC 9555, Bethesda, MD, 20892-9555, USA

    John S. Satterlee Ph.D.

  2. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

    Andrea Beckel-Mitchener

  3. National Institute of Environmental and Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA

    Kim McAllister, Frederick L. Tyson & Lisa Helbling Chadwick

  4. Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, NIH, MSC 9555, Bethesda, MD, 20892-9555, USA

    Dena C. Procaccini & Joni L. Rutter

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  1. John S. Satterlee Ph.D.
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  2. Andrea Beckel-Mitchener
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  3. Kim McAllister
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  4. Dena C. Procaccini
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Correspondence to John S. Satterlee Ph.D. .

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  1. National Institutes of Health, Rockville, Maryland, USA

    Mukesh Verma

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Satterlee, J.S. et al. (2015). Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program. In: Verma, M. (eds) Cancer Epigenetics. Methods in Molecular Biology, vol 1238. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1804-1_2

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  • DOI: https://doi.org/10.1007/978-1-4939-1804-1_2

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