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From the Producer Microorganisms to the Lasso Scaffold

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Lasso Peptides

Part of the book series: SpringerBriefs in Microbiology ((BRIEFSMICROBIOL))

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Abstract

Lasso peptides are members of the ribosomally synthesized and post-translationally modified peptides produced by bacteria. Currently known lasso peptides are produced in the phyla of Proteobacteria or Actinobacteria. They attract considerable attention because of their original interlocked structure endowed with high stability and important biological activities ranging from antimicrobials to enzyme inhibitors or receptor antagonists. The structure of lasso peptides consists of a peptidic tail trapped and locked into a macrolactam ring, forming a loop standing above and a threaded tail below the ring. This chapter describes the currently known lasso peptides concerning their origin, production and purification, structure and factors that contribute to maintain the lasso topology.

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  1. Laboratory of Communication Molecules and Adaptation of Microorganisms, Muséum National d’Histoire Naturelle CNRS, Paris, France

    Yanyan Li, Séverine Zirah & Sylvie Rebuffat

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Li, Y., Zirah, S., Rebuffat, S. (2015). From the Producer Microorganisms to the Lasso Scaffold. In: Lasso Peptides. SpringerBriefs in Microbiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1010-6_2

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